Neurofibro matosis: Oral and radiographic manifestations

Shapiro, Steven D.; Abramovitch, Kenneth; Dis, Margot L. Van; Skoczylas, Larry J.; Langlais, Robert P.; Jorgenson, Ronald J.; Young, Robert S.; Riccardi, Vincent M.

doi:10.1016/0030-4220(84)90350-5

Cited by 106 publications

(119 citation statements)

References 26 publications

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“…Exophthalmia caused by sphenoid wing dysplasia can also be present. 10 In the past, the frequency of oral manifestations of NF1 was estimated to occur in 4 to 7% of all cases. 7,11 However, two studies suggested that oral manifestations are much higher.…”

Section: Discussionmentioning

confidence: 99%

“…7,11 However, two studies suggested that oral manifestations are much higher. 4,10 The low frequency of oral manifestations in certain studies can be explained by the lack of radiographic examinations, ignoring the intraosseous manifestations. Oral manifestations were found in 72% of patients with NF1 in a study performed by Shapiro et al 10 According to a survey performed by D'Ambrosio et al 4 66% of his NF1 patients had at least one intra-oral manifestation of the disease and 58% of the patients presented manifestations in the maxilla and the mandible, detected by panoramic radiographs.…”

Section: Discussionmentioning

confidence: 99%

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Neurofibromatosis type I with periodontal manifestation. A case report and literature review

et al. 2004

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The term neurofibromatosis (NF) is used for a group of genetic disorders that primarily affect the cell growth of neural tissues. Neurofibromatosis type 1 (NF1), also known as von Recklinghausen´s disease, is the most common type of NF and accounts for about 90% of all cases. It is one of the most frequent human genetic diseases, with a prevalence of one case in 3,000 births. The expressivity of NF1 is extremely variable, with manifestations ranging from mild lesions to several complications and functional impairment. Oral manifestations can be found in almost 72% of NF1 patients. A case of a NF1 patient with a gingival neurofibroma in the attached gingiva of the lingual aspect of the lower central incisors is presented. The lesion was nodular, with sessile base, non-ulcerated, non-painful, with normal colour and measured 1 cm in diameter. An excisional biopsy of the oral lesion was performed. Histopathological and immunohistochemical analysis confirmed the clinical hypothesis of neurofibroma. Because NF1 is one of the most common genetic diseases and oral manifestations are very common, dentists should be aware of the characteristics of this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neurofibromatosis type I with periodontal manifestation. A case report and literature review

et al. 2004

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“…Commonly seen soft tissue lesions in the oral cavity include neurofibromas and enlarged fungiform papillae. 5 Skeletal findings include scoliosis-like spinal curvature, short stature, tibial pseudoarthrosis and dysplastic lesions of the skeleton. Certain osseous abnormalities, such as sphenoid dysplasia, are considered a diagnostic feature for NF1 (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Clinically aggressive central giant cell granulomas in two patients with neurofibromatosis 1

Edwards

Fantasia

Saini

et al. 2006

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…[1][2][3] They arise as a slow-growing, sessile, mobile and usually painless lesion that can vary in size from a small nodule to a large swelling. 4 Following the diagnosis of a neurofibroma, the possibility of neurofibromatosis must be considered.…”

Section: Differentialmentioning

confidence: 99%