Neurofibrillary tangles in elderly patients with late onset schizophrenia

Bozikas, Vasilis P.; Kovari, Eniko Veronika; Bouras, Constantin; Karavatos, Athanasios

doi:10.1016/s0304-3940(02)00189-1

Cited by 28 publications

(13 citation statements)

References 23 publications

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“…Moreover, pathological deposition of hyperphosphorylated MAP-tau (MAPT), which is the hallmark of several neurodegenerative disorders such as AD and frontotemporal dementia (FTD), has been described in elderly subjects with schizophrenia [175,176,177]. However, this issue is still under debate, because some autopsy studies do not report any significant difference in the prevalence of AD pathology between elderly schizophrenic patients and age-matched healthy controls [178,179,180,181]. Momeni and colleagues (2010) recently reported two relatives with an early age at onset (27 and 29 years) of schizophrenic symptoms showing a marked neuronal tau deposition, as confirmed at pathological examination [182].…”

Section: Cytoskeletal Abnormalities and Neuronal Inclusions In Schmentioning

confidence: 99%

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

Ryskalin

Limanaqi

Frati

et al. 2018

IJMS

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The mammalian target of rapamycin (mTOR) is an ubiquitously expressed serine-threonine kinase, which senses and integrates several intracellular and environmental cues to orchestrate major processes such as cell growth and metabolism. Altered mTOR signalling is associated with brain malformation and neurological disorders. Emerging evidence indicates that even subtle defects in the mTOR pathway may produce severe effects, which are evident as neurological and psychiatric disorders. On the other hand, administration of mTOR inhibitors may be beneficial for a variety of neuropsychiatric alterations encompassing neurodegeneration, brain tumors, brain ischemia, epilepsy, autism, mood disorders, drugs of abuse, and schizophrenia. mTOR has been widely implicated in synaptic plasticity and autophagy activation. This review addresses the role of mTOR-dependent autophagy dysfunction in a variety of neuropsychiatric disorders, to focus mainly on psychiatric syndromes including schizophrenia and drug addiction. For instance, amphetamines-induced addiction fairly overlaps with some neuropsychiatric disorders including neurodegeneration and schizophrenia. For this reason, in the present review, a special emphasis is placed on the role of mTOR on methamphetamine-induced brain alterations.

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Section: Cytoskeletal Abnormalities and Neuronal Inclusions In Schmentioning

confidence: 99%

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

Ryskalin

Limanaqi

Frati

et al. 2018

IJMS

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“…A more recent neuropathological study in older adult patients with schizophrenia was carried out by Bozikas et al [34]. Because cognitive impairment is often caused by AD, these researchers decided to study the prevalence of neurofibrillary tangles (NFTs) in older adult patients with late-onset schizophrenia-like symptomatology.…”

Section: Pathological Correlatesmentioning

confidence: 99%

“…In analogous fashion to the Bozikas et al [34] study, Casanova et al [16] used Braak's classification to assess the presence of neurofibrillary pathology in 64 patients with the diagnosis of schizophrenia or paraphrenia whose complete brains were available for examination. Patients were divided according to age at onset of symptomatology (ie, < 40 or > 40).…”

Section: Pathological Correlatesmentioning

confidence: 99%

The Pathology of Paraphrenia

Casanova

2010

Curr Psychiatry Rep

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The term paraphrenia refers to a condition characterized by a strong delusional component with preservation of thought and personality. Most affected patients are women. Although a late age at onset (> 60 years) has been proposed in the literature, evidence for this assertion remains debatable. Deterioration of cognitive functions occurs very slowly but may lead to mild dementia over a period of years. Pathological studies indicate the presence of neurofibrillary tangles (NFTs), primarily within the entorhinal cortex. Compared with the severity of neuritic changes, amyloid deposition remains scant. Pyramidal cells affected by NFTs appear to be preserved. Both the clinical history and neuropathology of paraphrenia are similar to those aspects described for NFT-predominant senile dementia. Risk factors, including organic lesions, may precipitate an earlier onset of symptomatology in patients exhibiting this pathology. Many of the symptoms in paraphrenia can be explained by involvement of the entorhinal cortex.

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“…Alguns autores afirmam que os pacientes esquizofrênicos estariam menos propensos a desenvolver doença de Alzheimer que a população geral (Bozikas et al, 2002). Brodaty et al (2003) observaram que os casos evoluídos para demência apresentavam escores menores em testes que avaliavam funções de atividades de vida diária e no MEEM na avaliação de base.…”

Section: Discussionunclassified

A evolução de longo prazo pode diferenciar dois subtipos de psicose de início tardio

Gomes¹,

Laks²

2005

Rev. psiquiatr. clín.

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ResumoA esquizofrenia de início tardio ainda é pouco estudada. Os trabalhos atuais apontam para uma patologia heterogênea, com perfil cognitivo semelhante ao encontrado na esquizofrenia com início no adulto jovem e dois tipos de evolução: um grupo com estabilização dos déficits neuropsicológicos e outro grupo com piora destes déficits ao longo do tempo. Apresentam-se dois casos clínicos avaliados por testes neuropsicológicos CAMCOG e Miniexame do Estado Mental (MEEM), Escore Isquêmico de Hachinski, Questionário de Atividades Funcionais de Pfeffer, PANSS e Inventário Neuropsiquiátrico. O desempenho cognitivo e das atividades de vida diária destes casos foram distintos, o que a p o n t a p a r a a n e c e s s i d a d e d e e s t u d o s p r o s p e c t i v o s c o m e n f o q u e neuropsicológico, para entendimento dos diferentes tipos de evolução das psicoses de início tardio.Palavras-chave: Esquizofrenia, idoso, diagnóstico. AbstractThere are few studies about late-onset schizophrenia (LOS). LOS is thought to be a heterogeneous pathology with a similar cognitive profile compared to adult schizophrenia and two types of evolution: one group with steady neuropsychological deficits and another group with progressive deficits. We report on two clinical cases evaluated with neuropsychological tests CAMCOG and MMSE, Hachinski's Ischemic Score, Pfeffer Functional Activities Questionnaire, PANSS and the Neuropsychiatric Inventory. The course of cognitive deficits and daily life activities were different, showing the need of prospective studies with neuropsychological approach to understand the clinical course and etiology of LOS.

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Neurofibrillary tangles in elderly patients with late onset schizophrenia

Cited by 28 publications

References 23 publications

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders

The Pathology of Paraphrenia

A evolução de longo prazo pode diferenciar dois subtipos de psicose de início tardio

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