Neurofeedback of core language network nodes modulates connectivity with the default-mode network: A double-blind fMRI neurofeedback study on auditory verbal hallucinations

Zweerings, Jana; Hummel, Bastian; Keller, Micha; Zvyagintsev, Mikhail; Schneider, Frank; Klasen, Martin; Mathiak, Klaus

doi:10.1016/j.neuroimage.2019.01.058

Cited by 45 publications

(29 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meta‐analyses have shown the predictive value of HF‐HRV for psychological well‐being, for example, low resting HF‐HRV has been linked to psychiatric disorders such as depression (e.g., Kemp et al., 2010) and schizophrenia (Montaquila, Trachik, & Bedwell, 2015) which may be related to its role in self‐regulatory top‐down control capacity (Holzman & Bridgett, 2017). Further, a better understanding of the coupling between brain activation and peripheral physiological regulation may enable a better reduction of artefacts in the widely applied RS fMRI (Tong, Hocke, & Frederick, 2019; Zweerings et al, 2019) and thereby adding to its clinical and scientific value.…”

Section: Discussionmentioning

confidence: 99%

Neural correlates of fluctuations in the intermediate band for heart rate and respiration are related to interoceptive perception

Keller

Pelz²,

Perlitz³

et al. 2020

Psychophysiology

Self Cite

View full text Add to dashboard Cite

The autonomic nervous system (ANS) receives modulatory input from high-level supra-tentorial brain structures, which affects peripheral physiological measures such as heart rate variability (HRV), respiration, and electrodermal activity (see Beissner, Meissner, Bär, & Napadow, 2013 for a meta-analysis). For instance, in the neurovisceral integration model for HRV (Thayer & Lane, 2009), neocortical areas such as the prefrontal and cingulate cortex exert tonic inhibitory control over brainstem circuitry underlying the ANS regulation. A similar cortico-limbic model has been proposed for sensorimotor integration of respiration (Evans, 2010), with an interplay of volitional respiratory control (pre-motor and supplementary motor area (SMA)) and interoceptive integration areas (anterior cingulate cortex (ACC), insula, and amygdala). These models overlap in core autonomic network areas, including the cingulate cortex, insula, and amygdala

show abstract

Section: Discussionmentioning

confidence: 99%

Neural correlates of fluctuations in the intermediate band for heart rate and respiration are related to interoceptive perception

Keller

Pelz²,

Perlitz³

et al. 2020

Psychophysiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Zweerings et al (2019) used rt-fMRI NF to target left-hemispheric language nodes in 21 patients with SCZ with AVH and 35 healthy controls. 54 Subjects in the SCZ group continued with medications without any changes. The study design was a double blind, randomized, crossover intervention.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review of the Potential Use of Neurofeedback in Patients With Schizophrenia

Gandara

Pineda

Shu

et al. 2020

Schizophrenia Bulletin Open

View full text Add to dashboard Cite

Schizophrenia (SCZ) is a neurodevelopmental disorder characterized by positive symptoms (hallucinations and delusions), negative symptoms (anhedonia, social withdrawal) and marked cognitive deficits (memory, executive function, and attention). Current mainstays of treatment, including medications and psychotherapy, do not adequately address cognitive symptoms, which are essential for everyday functioning. However, recent advances in computational neurobiology have rekindled interest in neurofeedback (NF), a form of self-regulation or neuromodulation, in potentially alleviating cognitive symptoms in patients with SCZ. Therefore, we conducted a systematic review of the literature for NF studies in SCZ to identify lessons learned and to identify steps to move the field forward. Our findings reveal that NF studies to date consist mostly of case studies and small sample, single-group studies. Despite few randomized clinical trials, the results suggest that NF is feasible and that it leads to measurable changes in brain function. These findings indicate early proof-of-concept data that needs to be followed up by larger, randomized clinical trials, testing the efficacy of NF compared to well thought out placebos. We hope that such an undertaking by the field will lead to innovative solutions that address refractory symptoms and improve everyday functioning in patients with SCZ.

show abstract

“…The inferior frontal gyrus, superior temporal gyrus, and supra-marginal gyrus participate in AVH processing. [9,43,44] We postulated that the intergroup differences might be related to the pathological features of insight; a decreased gFCD in the frontal lobe might deteriorate the functional activity in the temporal and inferior frontal gyrus, thus the abnormal activity of these regions could not be inhibited, reflected as an increased gFCD in these regions. This postulation requires further studies to clarify, despite many AVH hypotheses supporting the disinhibit postulation.…”

Section: Discussionmentioning

confidence: 99%

Brain function differences in drug-naïve first-episode auditory verbal hallucination-schizophrenia patients with versus without insight

Chen

Zhuo

Feng

et al. 2019

Chinese Medical Journal

View full text Add to dashboard Cite

Background:Few studies have reported brain function differences in drug-naïve first-episode schizophrenia patients who had auditory verbal hallucinations (AVH) with insight vs. those without insight. This study aimed to investigate brain function differences between drug-naïve first-episode AVH-schizophrenia patients with and without insight.Methods:Forty first-episode drug-naïve AVH-schizophrenia patients with or without insight and 40 healthy controls between December 2016 and December 2018 were recruited in this study. The auditory hallucinations rating scale (AHRS) was used to assess AVH severity, while the insight and treatment attitudes questionnaire was used to distinguish insight. The global functional connectivity density (gFCD) between different groups was compared using a voxel-wise one-way analysis of covariance. The relationship between gFCD and AHRS total scores were analyzed using voxel-wise multiple regression.Results:Finally, 13 first-episode drug-naïve AVH-schizophrenia patients with insight, 15 AVH-schizophrenia patients without insight, and 20 healthy controls were included for analysis. Except for global assessment of functioning scores, there were no significant differences in sociodemographic information between the AVH-schizophrenia and healthy groups (P > 0.05). Compared to the healthy controls, AVH-schizophrenia patients with insight demonstrated a decreased gFCD in the supra-marginal gyrus within the primary auditory cortex, while those without insight demonstrated an increased gFCD in the inferior frontal gyrus and superior temporal gyrus and decreased gFCD in the supplemental motor area. Compared to the AVH-schizophrenia patients with insight, those without insight demonstrated an increased gFCD in the supra-marginal gyrus and posterior superior temporal lobule and a decreased gFCD in the frontal lobe. No significant correlation between gFCD and AVH severity (AHRS total score: r = 0.23, P = 0.590; and frequency: r = 0.42, P = 0.820) was found in both AVH-schizophrenia groups.Conclusions:The gFCD-aberrant brain regions in the AVH-schizophrenia patients without insight were wider compared to those with insight, although the AHRS scores were not significantly different. The AVH-schizophrenia patients without insight had wide functional impairment in the frontal lobule, which may underlie the lack of insight and the abnormal hyperactivity in the inferior frontal gurus and temporal lobe related to the AVH symptoms.

show abstract

Neurofeedback of core language network nodes modulates connectivity with the default-mode network: A double-blind fMRI neurofeedback study on auditory verbal hallucinations

Cited by 45 publications

References 46 publications

Neural correlates of fluctuations in the intermediate band for heart rate and respiration are related to interoceptive perception

Neural correlates of fluctuations in the intermediate band for heart rate and respiration are related to interoceptive perception

A Systematic Review of the Potential Use of Neurofeedback in Patients With Schizophrenia

Brain function differences in drug-naïve first-episode auditory verbal hallucination-schizophrenia patients with versus without insight

Contact Info

Product

Resources

About