Neurofeedback ineffective in paediatric brain tumour survivors: Results of a double-blind randomised placebo-controlled trial

Ruiter, M.; Oosterlaan, Jaap; Meeteren, A.Y.N. Schouten-van; Maurice‐Stam, Heleen; Vuurden, Dannis G. van; Gidding, Corrie; Beek, Laura Rachel; Granzen, Bernd; Caron, Huib N.; Grootenhuis, Martha A.

doi:10.1016/j.ejca.2016.04.020

Cited by 17 publications

(25 citation statements)

References 42 publications

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“…Considering the fact that effective interventions for improvement of neurocognitive functioning in survivors of a brain tumor are largely lacking, it is important to look for alternative ways to improve neurocognitive functioning in this vulnerable population; the results of this study point at psychosocial/behavioral factors as potential risk factors for sleep problems, indicating that behavioral sleep interventions could be one such alternative way. A behavioral sleep intervention consisting of information on normal sleep, sleep hygiene, and management strategies for sleep behavior in children with ADHD has been shown to improve both sleep and working memory in an RCT .…”

Section: Discussionmentioning

confidence: 94%

“…Participants did not differ from the survivors who declined participation (n = 71) regarding age at assessment, gender, radiotherapy, and tumor location. Participants more often received chemotherapy (43% vs 27%) and the time since diagnosis was longer (mean 7.0 [SD 3.6] vs 6.1 [SD 3.3] years) …”

Section: Resultsmentioning

confidence: 99%

“…Baseline data of a randomized controlled trial (RCT) on the effectiveness of neurofeedback to improve neurocognitive functioning are used for the current study . Survivors of a brain tumor with parent‐reported neurocognitive complaints, aged 8‐18 years, who completed tumor treatment at least 2 years ago, were approached through their oncologist or psychologist for participation in the RCT.…”

Section: Methodsmentioning

confidence: 99%

“…As pediatric brain tumor survivors are at risk for both sleep problems and neurocognitive impairment, improvement of sleep could be a way to benefit neurocognitive functioning in these children, for which proper interventions are currently scarce . Exploring the extent of sleep problems in a vulnerable subgroup of brain tumor survivors—children with neurocognitive complaints—and subsequently examining the relation between sleep and behavioral executive functioning in this specific population is an important step towards developing and implementing sleep interventions.…”

Section: Introductionmentioning

confidence: 99%

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High occurrence of sleep problems in survivors of a childhood brain tumor with neurocognitive complaints: The association with psychosocial and behavioral executive functioning

Kooten

Maurice‐Stam

Schouten

et al. 2019

Pediatric Blood & Cancer

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Background: Survivors of childhood brain tumors are prone to sleep and neurocognitive problems.Effective interventions to improve neurocognitive functioning are largely lacking. In general, sleep problems are negatively related to neurocognitive functioning, but this relationship is unclear in survivors of childhood brain tumors. Therefore, the occurrence of sleep problems, potential risk factors, and the relation between sleep and executive functioning were evaluated. Procedure: Baseline data of a randomized controlled trial on the effectiveness of neurofeedback were used. Childhood brain tumor survivors 8-18 years of age with parent-reported neurocognitive complaints ≥2 years after treatment were eligible. Parents completed the Sleep Disturbance Scale for Children. Executive functioning was assessed by parents and teachers (Behavior Rating Inventory of Executive Functioning). Multiple linear regression analyses were used to examine sociodemographic and medical characteristics and emotional difficulties and hyperactivity/inattention (Strength and Difficulties Questionnaire) as potential risk factors for sleep problems, and to assess the association between sleep and executive functioning. Results: Forty-eight percent of survivors (n = 82, 7.0 ± 3.6 years post diagnosis, age 13.8 ± 3.2 years) had sleep problems and scored significantly worse than the norm on the subscales Initiating and Maintaining Sleep, Excessive Somnolence, and the total scale (effect sizes 0.58-0.92). Emotional problems and/or hyperactivity/inattention were independent potential risk factors. Sleep problems were associated with worse parent-reported executive functioning. Conclusions: Sleep problems occur among half of childhood brain tumor survivors with neurocognitive problems, and are associated with worse executive functioning. Future studies should focus on the development of sleep interventions for this population, to improve sleep as well as executive functioning. K E Y W O R D S executive functioning, pediatric hematology/oncology, sleep Abbreviations: ADHD/ADD, attention deficit (hyperactivity) disorder; BRIEF, Behavior Rating Inventory of Executive Functioning; DA, disorders of arousal; CBT, cognitive behavioral therapy;

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Section: Discussionmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High occurrence of sleep problems in survivors of a childhood brain tumor with neurocognitive complaints: The association with psychosocial and behavioral executive functioning

Kooten

Maurice‐Stam

Schouten

et al. 2019

Pediatric Blood & Cancer

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“…Also, successful applications in patients with epilepsy ( 78 ) and chronic fatigue ( 79 ) have been reported. In contrast, one study has reported no significant differences between neurofeedback and placebo feedback training in pediatric brain tumor survivors ( 80 ). In this context, however, only beta oscillations or sensorimotor rhythms (12–15 Hz) were targeted, not taking theta frequencies, which play a crucial role in executive functioning, into account.…”

Section: Oscillation-based Interventions For Executive Dysfunctions: mentioning

confidence: 99%

Executive Function Deficits in Seriously Ill Children—Emerging Challenges and Possibilities for Clinical Care

et al. 2018

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The past years have seen an incredible increase in the quality and success rates of treatments in pediatric medicine. One of the resulting major challenges refers to the management of primary or secondary residual executive function deficits in affected children. These deficits lead to problems in the ability to acquire, understand, and apply abstract and complex knowledge and to plan, direct, and control actions. Executive functions deficits are important to consider because they are highly predictive of functioning in social and academic aspects of daily life. We argue that current clinical practice does not sufficiently account for the complex cognitive processes in this population. This is because widely applied pharmacological interventions only rarely account for the complexity of the underlying neuronal mechanisms and do not fit well into possibly powerful “individualized medicine” approaches. Novel treatment approaches targeting deficits in executive functions in seriously ill children could focus on neuronal oscillations, as these have some specific relations to different aspects of executive function. Importantly, such treatment approaches can be individually tailored to the individuals’ deficits and can be transferred into home-treatment or e-health solutions. These approaches are easy-to-use, can be easily integrated into daily life, and are becoming increasingly cost-effective.

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Rehabilitation and Pediatric Oncology: Supporting Patients and Families During and After Treatment

Paltin

Schofield

Baran

2018

Curr Phys Med Rehabil Rep

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Neurofeedback ineffective in paediatric brain tumour survivors: Results of a double-blind randomised placebo-controlled trial

Cited by 17 publications

References 42 publications

High occurrence of sleep problems in survivors of a childhood brain tumor with neurocognitive complaints: The association with psychosocial and behavioral executive functioning

High occurrence of sleep problems in survivors of a childhood brain tumor with neurocognitive complaints: The association with psychosocial and behavioral executive functioning

Executive Function Deficits in Seriously Ill Children—Emerging Challenges and Possibilities for Clinical Care

Rehabilitation and Pediatric Oncology: Supporting Patients and Families During and After Treatment

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