Neurofeedback impacts cognition and quality of life in pediatric focal epilepsy: An exploratory randomized double-blinded sham-controlled trial

Morales-Quezada, León; Martínez, Diana; El-Hagrassy, Mirret M.; Kaptchuk, Ted J.; Sterman, M. B.; Yeh, Gloria Y.

doi:10.1016/j.yebeh.2019.106570

Cited by 20 publications

(18 citation statements)

References 47 publications

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“…Neurofeedback is based on neurobiological findings, but the implementation and reward methods follow the principles of psychotherapy (Morales-Quezada et al, 2019;Strehl, 2014). Discussion regarding the types of rewards and the amount and frequency of feedback is still ongoing (Sherlin et al, 2011;Sulzer et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Effect of Threshold Setting on Neurofeedback Training

Nam

Choi²

2020

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This study aimed to confirm the effect of threshold setting on the performance of neurofeedback training. The experimental conditions used to confirm the effect of the different threshold settings on the degree of electroencephalographic (EEG) changes in the initial training conditions were unfamiliar to neurofeedback. Rewards were presented in low, medium, and high frequency groups according to the different threshold settings. The sensory-motor rhythm (SMR; 12-15 Hz) neurofeedback protocol was performed for all groups. We looked at whether the posttraining brain wave increases were significant in each group compared to the brain waves during training. The SMR protocol was performed in a single session and consisted of four blocks totaling 10 minutes. EEG data was collected before training as a baseline, during training, and posttraining. The results of the group analysis showed that the mean SMR value of the posterior EEG in the high frequency group was significantly higher than the SMR value in the first EEG block. The threshold settings affected learning in neurofeedback training. It was found that initially setting the threshold value for easy compensation was more effective than the setting for hard compensation.

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Section: Introductionmentioning

confidence: 99%

Effect of Threshold Setting on Neurofeedback Training

Nam

Choi²

2020

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“…Although double-blinded randomized clinical trials are considered standard for pharmaceutical interventions, these methods are not feasible for a non-invasive training modality like NFB, just as a randomized double-blinded placebo-controlled study of the benefits of exercise is difficult since one cannot blind a subject to receiving exercise. Such double-blind controlled clinical trials demonstrated the efficacy in epilepsy and other disorders (Finley, 1976; Lantz & Sterman, 1988; Morales-Quezada et al, 2019; Nicholson et al, 2020; Whitsett et al, 1982).…”

Section: Nfb For Epilepsy: Research Implicationsmentioning

confidence: 98%

“…Most recently, studies continue to confirm that sensorimotor rhythm NFB training results in clearly defined seizure, motor, cognitive, and other brain improvements over the sensorimotor cortex (Hayashi et al, 2020; Jeunet et al, 2019; Kober et al, 2020; Morales-Quezada et al, 2019).…”

Section: Neurofeedback For Seizures/epilepsy—background Of Extensive ...mentioning

confidence: 98%

Biofeedback and Health Evidence-Based Biofeedback and Neurofeedback for People with Epilepsy and Seiz

Turner¹

2022

Policy Insights from the Behavioral and Brain Sciences

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Epilepsy is the fourth most common neurological disorder worldwide despite many anti-seizure medications. Biofeedback (BFB) and neurofeedback (NFB) have shown significant promise since the 1960s to improve seizure control, abnormalities in electroencephalography (EEG) and quantitative-EEG, and quality of life. Epilepsy is a disease of brain networks and BFB/NFB is a non-invasive, brain-centered, low-risk, low-cost, and reliable treatment for people with seizures/epilepsy and especially since standard seizure medications and epilepsy surgery often do not result in complete seizure control. Neuroscience healthcare clinician experience and a 60-year literature foundation show that BFB/NFB to improve brain dysregulation and abnormal network dynamics are known to be at the root of seizures/epilepsy. BFB/NFB trains individuals to self-regulate brain activity through real-time performance feedback. An exhaustive literature review for NFB/BFB and seizures/epilepsy (1960s–present) yielded 150 articles documenting improvements in seizures and EEG/QEEG abnormalities. Clinicians, insurers, and the public should support BFB/NFB as a first-line intervention for seizures/epilepsy.

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“…A meta-analysis showed that 82% of participants had >30% seizure reduction after neurofeedback therapy [ 75 ]. A recent RCT illustrated that sensorimotor rhythm neurofeedback training improved cognition in 44 children and adolescents with controlled focal epilepsy [ 88 ]. The effectiveness of neurofeedback in the treatment of chronic insomnia is still controversial [ 89 ].…”

Section: Relaxation Therapiesmentioning

confidence: 99%

The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy

Peng

Ding

Wang

2021

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Background: There is a complex and interactive relationship between sleep and epilepsy. Sleep disorders are common in patients with epilepsy, and methods for managing sleep disorders in patients with epilepsy are limited. Objective: This review is to address the relationships among sleep, sleep disorders, and epilepsy, focusing on the managements for sleep disorders in epilepsy, including some complementary and alternative therapies. Methods: The terms related to “sleep” and “epilepsy” were searched in “Pubmed” and “Cochrane Library”. Results: Sleep stages differently affects both of seizures and interictal epileptiform discharges. Seizures disrupt sleep architectures greatly, especially when arising from sleep in the night. Insomnia and obstructive sleep apnea (OSA) are the most frequent types of comorbid sleep disorders in patients with epilepsy. Pharmacological agents with both anti-convulsant and sedative effects are the priorities for comorbid sleep disorders in epilepsy. Continuous positive airway pressure (CPAP) therapy is the most effective non-pharmacological method to improve OSA and reduce seizures. Complementary and alternative therapies such as Chinese traditional medicine, cognitive behavioral therapy, meditation, yoga, neurofeedback, and acupuncture may have benefits on reducing seizures and improving sleep quality simultaneously by alleviating stress and seizure triggers, however, evidence-based therapies are still in deficiency. Conclusion: Managements for sleep disorders in patients with epilepsy are challenging. Large sample randomized controlled trials are in demand in the future.

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Neurofeedback impacts cognition and quality of life in pediatric focal epilepsy: An exploratory randomized double-blinded sham-controlled trial

Cited by 20 publications

References 47 publications

Effect of Threshold Setting on Neurofeedback Training

Effect of Threshold Setting on Neurofeedback Training

Biofeedback and Health Evidence-Based Biofeedback and Neurofeedback for People with Epilepsy and Seiz

The Management and Alternative Therapies for Comorbid Sleep Disorders in Epilepsy

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