Neuroethical Issues of the Brain/MINDS Project of Japan

Sadato, Norihiro; Morita, Kentaro; Kasai, Kiyoto; Fukushi, Tamami; Nakamura, Katsuki; Nakazawa, Eisuke; Okabe, Susumu

doi:10.1016/j.neuron.2019.01.006

Cited by 16 publications

(9 citation statements)

References 8 publications

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“…Sharing neuropsychiatric patient data, which may contain information linked to subjects’ privacy, requires special attention ( Sadato et al, 2019 ). Therefore, the Brain/MINDS Beyond project put NCNP as the core site for supporting ethical considerations.…”

Section: Ethics and Data Sharingmentioning

confidence: 99%

Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan

Koike

Tanaka

Okada

et al. 2021

NeuroImage: Clinical

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Highlights The Brain/MINDS beyond project plans to collect multi-site/scanner brain MRI data. Prospective harmonization of MRI was achieved by standardizing scanning protocols. The preliminary data showed moderate reliability of brain connectome data. Completing traveling subject plan will allow robust statistical harmonization. Scanning protocols are publicly available and data will also be shared by 2024.

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Section: Ethics and Data Sharingmentioning

confidence: 99%

Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan

Koike

Tanaka

Okada

et al. 2021

NeuroImage: Clinical

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“…Sharing neuropsychiatric patient data, which may contain information linked to subjects' privacy, requires special attention (Sadato et al, 2019). Therefore,…”

Section: Ethical Regulationmentioning

confidence: 99%

Brain/MINDS Beyond Human Brain MRI Project: A Protocol for Multi-Site Harmonization across Brain Disorders Throughout the Lifespan

Koike

Tanaka

Okada

et al. 2020

Preprint

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63Psychiatric and neurological disorders are afflictions of the brain that can affect individuals 64 throughout their lifespan. Many brain magnetic resonance imaging (MRI) studies have been 65 conducted; however, imaging-based diagnostic and therapeutic biomarkers are not yet well 66 established. The Brain/MINDS Beyond human brain MRI project (FY2018 ~ FY2023) is a 67 multi-site harmonization study aiming to establish clinically-relevant imaging biomarkers using 68 multiple high-performance scanners, standardized multi-modal imaging, and a study design that 69 includes traveling subjects. This project began with 13 clinical research sites that collect MRI 70 data on psychiatric and neurological disorders across the lifespan and three research sites that 71 design and develop measurement procedures, neuroimaging protocols, data storage and sharing, 72 and analysis tools. Brain images obtained with the Harmonization protocol (HARP) are 73 preprocessed and analyzed using approaches developed by the Human Connectome Project, 74 generating preliminary cortical structure, function, and connectivity measures that are 75 comparable across scanners. The use of 'travelling subjects', in which study participants travel to 76 multiple sites to undergo scanning with standardized neuroimaging techniques, enable us to 77 minimize the measurement bias between scanners and protocols and to increase the sensitivity 78 and specificity of case-control studies. All the imaging and demographic and clinical data are 79shared between the participating sites and will be made publicly available in 2024. To the best of 80 our knowledge, this is the first multi-site human brain MRI project to explore multiple 81 psychiatric and neurological disorders across the lifespan. The Brain/MINDS Beyond human 82 brain MRI project will help to identify the common and disease-specific pathophysiology 83 features of brain diseases and develop imaging biomarkers for clinical practice. 84 4 Keywords 85 Multi-site Study; HCP-style Brain Imaging; Psychiatric Disorders; Neurological Disorders; 86 Harmonization Protocol; Traveling Subjects 87 5 Text 88 Abbreviations 89 DALYs, disability-adjusted life years 90 MRI, magnetic resonance imaging 91 HCP, Human Connectome Project 92 ABCD, Adolescent Brain Cognitive Development 93 BPD, bipolar disorder 94 MDD, major depressive disorder 95 DecNef, Decoded Neurofeedback 96 ASD, autism spectrum disorder 97 ADNI, Alzheimer's Disease Neuroimaging Initiative 98 AD, Alzheimer's disease 99 MCI, mild cognitive impairment 100 PPMI, Parkinson's Progression Markers Initiative 101 PD, Parkinson's disease 102 T1w, T1-weighted 103 T2w, T2-weighted 104 rsfMRI, resting state functional MRI

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“…It is important for researchers who study nonhuman primates to contribute not only to their own study but also to animal welfare and ethics (Amadio et al, 2018;Buller, 2018;Milham et al, 2020;Milham et al, 2018;Sadato et al, 2019). The challenge of understanding the human brain and its disorders means that nonhuman primate research is increasingly needed, although it is essential that this research is complemented by studies using other approaches, and other alternatives to (in vivo) nonhuman primate use (Lemon, 2018).…”

Section: Necessary Consideration Of Animal Ethics Welfare and Consementioning

confidence: 99%

The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: the second phase of the archive of digital records

Sakai

Hata

Shintaku

et al. 2020

Preprint

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A comparison of neuroanatomical features of the brain between humans and our evolutionary relatives, nonhuman primates, is key to understanding the human brain system and the neural basis of mental and neurological disorders. Although most comparative MRI studies of human and nonhuman primate brains have been based on brains of primates that had been used as subjects in experiments, it is essential to investigate various species of nonhuman primates in order to elucidate and interpret the diversity of neuroanatomy features among humans and nonhuman primates. To develop a research platform for this purpose, it is necessary to harmonize the scientific contributions of studies with the standards of animal ethics, animal welfare, and the conservation of brain information for long-term continuation of the field. In previous research, we first developed an open-resource repository of anatomical images obtained using 9.4-T ex vivo MRI of postmortem brain samples from 12 nonhuman primate species, and which are stored at the Japan Monkey Centre. In the present study, as a second phase, we released a collection of T2-weighted images and diffusion tensor images obtained in nine species: white-throated capuchin, Bolivian squirrel monkey, stump-tailed macaque, Tibet monkey, Sykes’ monkey, Assamese macaque, pig-tailed macaque, crested macaque, and chimpanzee. Our image repository should facilitate scientific discoveries in the field of comparative neuroscience. This repository can also promote animal ethics and animal welfare in experiments with nonhuman primate models by optimizing methods for in vivo and ex vivo MRI scanning of brains and supporting veterinary neuroradiological education. In addition, the repository is expected to contribute to conservation, preserving information about the brains of various primates, including endangered species, in a permanent digital form.

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Neuroethical Issues of the Brain/MINDS Project of Japan

Cited by 16 publications

References 8 publications

Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan

Brain/MINDS beyond human brain MRI project: A protocol for multi-level harmonization across brain disorders throughout the lifespan

Brain/MINDS Beyond Human Brain MRI Project: A Protocol for Multi-Site Harmonization across Brain Disorders Throughout the Lifespan

The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: the second phase of the archive of digital records

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