Neuroendocrinology of the pancreas; role of brain–gut axis in pancreatic secretion

Konturek, Stanisław J.; Zabielski, R.; Konturek, J. W.; Czarnecki, John

doi:10.1016/j.ejphar.2003.08.042

Cited by 106 publications

(66 citation statements)

References 68 publications

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“…Release of pancreatic polypeptide and somatostatin from the pancreas results in local inhibition of acinar cell exocytosis (38) . Cholinergic stimulation of pancreatic enzyme exocytosis is also inhibited by elevated circulating concentrations of pancreatic polypeptide (39) , glucagon-like peptide-1 (40,41) and peptide YY (released from the ileum) and ghrelin and leptin (42,43) .…”

Section: Secretionmentioning

confidence: 99%

Physiological parameters governing the action of pancreatic lipase

et al. 2010

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The most widely used pharmacological therapies for obesity and weight management are based on inhibition of gastrointestinal lipases, resulting in a reduced energy yield of ingested foods by reducing dietary lipid absorption. Colipase-dependent pancreatic lipase is believed to be the major gastrointestinal enzyme involved in catalysis of lipid ester bonds. There is scant literature on the action of pancreatic lipase under the range of physiological conditions that occur within the human small intestine, and the literature that does exist is often contradictory. Due to the importance of pancreatic lipase activity to nutrition and weight management, the present review aims to assess the current body of knowledge with regards to the physiology behind the action of this unique gastrointestinal enzyme system. Existing data would suggest that pancreatic lipase activity is affected by intestinal pH, the presence of colipase and bile salts, but not by the physiological range of Ca ion concentration (as is commonly assumed). The control of secretion of pancreatic lipase and its associated factors appears to be driven by gastrointestinal luminal content, particularly the presence of acid or digested proteins and fats in the duodenal lumen. Secretion of colipase, bile acids and pancreatic lipase is driven by cholecystokinin and secretin release.

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Section: Secretionmentioning

confidence: 99%

Physiological parameters governing the action of pancreatic lipase

et al. 2010

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“…More recently, however, it was clearly demonstrated that freshly isolated human pancreatic acini neither release amylase in response to CCK8 nor to gastrin; a secretory response to carbachol was shown to document viability of the acini preparation as well as a response to CCK8 following CCK 2 receptor transfection in these acini (Ji et al 2001). To understand how pancreatic enzyme secretion is controlled by CCK in larger mammals and also possibly in rodents, future studies will have to focus on vagovagal reflex stimulation as elegantly described and documented by Konturek et al (2003b) from an earlier observation that pancreatic enzyme secretion induced by CCK and secretin in human subjects was inhibited not only by the CCK 1 receptor antagonist loxiglumide but also by atropine. It suggests that neuronal pathways play an important role in the action of CCK on pancreatic enzyme secretion (Gabryelewicz et al 1990;Owyang, 1996) (see pp.…”

Section: Global Effects Of Gastrin and Cholecystokinin In The Gutmentioning

confidence: 99%

“…Over 20 years later, Jorpes & Mutt (1966) established that pancreozymin was the same substance as CCK. Moreover, later on it became evident that both regulatory substances did not totally fit into the classical hormonal definition as the other humoral substances act through blood circulation to induce specific biological effects in their target organs, since neurocrine, paracrine and luminocrine effects of CCK and/or gastrin have been reported (Konturek et al 1986a(Konturek et al , 2003bOwyang, 1996;Deng & Whitcomb, 1998). Therefore, it may be more proper to call gastrin and CCK gut-regulatory peptides (belonging to the CCK -gastrin family of peptides) rather than hormones.…”

Section: Introductionmentioning

confidence: 99%

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

et al. 2006

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The aim of the present review is to synthesise and summarise our recent knowledge on the involvement of cholecystokinin (CCK) and gastrin peptides and their receptors in the control of digestive functions and more generally their role in the field of nutrition in mammals. First, we examined the release of these peptides from the gut, focusing on their molecular forms, the factors regulating their release and the signalling pathways mediating their effects. Second, general physiological effects of CCK and gastrin peptides are described with regard to their specific receptors and the role of CCK on vagal mucosal afferent nerve activities. Local effects of CCK and gastrin in the gut are also reported, including gut development, gastrointestinal motility and control of pancreatic functions through vagal afferent pathways, including NO. Third, some examples of the intervention of the CCK and gastrin peptides are exposed in diseases, taking into account intervention of the classical receptor subtypes (CCK 1 and CCK 2 receptors) and their heterodimerisation as well as CCK-C receptor subtype. Finally, applications and future challenges are suggested in the nutritional field (performances) and in therapy with regards to the molecular forms or in relation with the type of receptor as well as new techniques to be utilised in detection or in therapy of disease. In conclusion, the present review underlines recent developments in this field: CCK and gastrin peptides and their receptors are the key factor of nutritional aspects; a better understanding of the mechanisms involved may increase the efficiency of the nutritional functions and the treatment of abnormalities under pathological conditions.

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“…Complementary work must be done in this area, as was suggested by Guilloteau et al (2002). Moreover, besides the gut regulatory peptides, other ways need to be explored and integrated to suggest a common overview of the mechanisms involved, as was recently done for pancreatic secretion (Konturek et al, 2003). The aim of the synthesis of the studies in these complementary areas must have an integrative objective and try to relate the physiological status of the molecules, cells, tissues, organs, systems, functions and finally the whole body in its environment.…”

Section: Discussionmentioning

confidence: 99%

Gut regulatory peptides as mediators of gastrointestinal tract growth, motility and development of secretion in young ruminants

Guilloteau

Zabielski²

2005

J. Anim. Feed Sci.

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In mammalian species, the prenatal development of foetal tissues is programmed to result in the organization of different functions of the organism. During development, non-genetic factors are involved and act through regulatory substances. It is frequently said that the GIT represents "the largest endocrine organ in the body". Most of these substances depend on an intricate regulatory complex increasingly recognized as a unique system having multiple aspects, including hormonal, nervous and immune ones. The link in this unique system comprises a number of substances whose task is to translate the signals. Among them, the gut regulatory peptides are considered to be substances that play a pivotal role in digestive functions. This review will deal with recent advances in the regulation of digestive functions in which the gut regulatory peptides are involved during development in calf i.e., during foetal life, after birth, during maintenance at the preruminant stage, and at weaning. This report will be devoted in particular to gut regulatory peptides as mediators of gastrointestinal (GI) growth, motility and development of secretion and adaptations. Increasing knowledge about the biological functions and mechanisms of gut regulatory peptide actions could help in managing the growth and maturation of the gastrointestinal tract (GTI), to better optimize digestive motility and productions. It is particularly important in the young to help them to better pass through such critical stages as the neonatal and weaning periods.

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Neuroendocrinology of the pancreas; role of brain–gut axis in pancreatic secretion

Cited by 106 publications

References 68 publications

Physiological parameters governing the action of pancreatic lipase

Physiological parameters governing the action of pancreatic lipase

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

Gut regulatory peptides as mediators of gastrointestinal tract growth, motility and development of secretion in young ruminants

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