Neuroendocrine tumors: review of the literature

Araújo, Nicole Almeida de Alencar; Pantaroto, André; Tosello, C.

doi:10.6006/perspectmed.2012.0601127466440334

Cited by 4 publications

(13 citation statements)

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“…The metastatic disease signals a worse prognosis. Other worse prognostic factors identified at histopathological examination are vascular and lymphatic invasion, a high grade of cell atypia, an increased nucleus/cytoplasm ratio, the presence and extension of necrosis, besides an increased mitotic index [ 2 , 8 ]. The cell proliferation index analyzed by immunohistochemistry (Ki67) contributes to this assessment.…”

Section: Discussionmentioning

confidence: 99%

“…The cell proliferation index analyzed by immunohistochemistry (Ki67) contributes to this assessment. Poorly differentiated NEC, with a Ki67 >20%, are associated with worse prognosis [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasia, gathered together because of their common features: tumors capable of secreting hormones, neurotransmitters, neuromodulators and neuropeptides. Neuroendocrine cells, supposedly precursors of this group of neoplasia, are found in all solid organs, skin and mucosae; therefore, NETs may originate in several locations [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…Within the spectrum of NETs, on the one side, well-differentiated NETs can be found (formerly called carcinoid tumors), usually with a painless clinical course, besides being curable by simple resection when viable. On the other side of the spectrum, there are poorly differentiated neuroendocrine carcinomas (NECs), of a more aggressive clinical course, producing metastases with greater frequency and, usually, requiring isolated or adjuvant chemotherapy [ 1 , 2 ]. Cutaneous manifestations from NETs are not uncommon, especially those exhibiting carcinoid syndrome.…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous Metastasis of Neuroendocrine Carcinoma with Unknown Primary Site: Case Report and Review of the Literature

Amorim¹,

Quintella

Cuzzi

et al. 2015

Case Rep Dermatol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cutaneous Metastasis of Neuroendocrine Carcinoma with Unknown Primary Site: Case Report and Review of the Literature

Amorim¹,

Quintella

Cuzzi

et al. 2015

Case Rep Dermatol

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show abstract

“…Nevertheless, we emphasize that there are exceptions in cellular behavior based on histological characteristics, but it should be considered that some histological characteristics determine NET tumor behavior, such as vascular, lymphatic, and organ wall invasion, degree of cellular atypia, nucleocytoplasmic ratio, presence and extension of tumor necrosis and mitotic index. Markers of cell proliferation (Ki-67 Index) and p53 expression are important in determining tumor aggressiveness [11].…”

Section: Classification Of Neuroendocrine Pancreatic Tumorsmentioning

confidence: 99%

Pancreatic Neuroendocrine Tumors: A Literature Review

Gomes¹,

Laiso²,

Knop³

et al. 2020

JBTH

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Pancreatic neuroendocrine tumors (PNETs) affect 1%-3% of patients with pancreatic cancer. This tumor is rare, difficult to diagnose, and clinically laborious. They have an estimated incidence of up to 1 case per 100,000 inhabitants every year. Up on diagnosis, most PNETs are considered malignant, with low healing potential, lesions that are generally unresectable, and a metastasis rate of aproximately 50%. PNETs are classified as functional and non-functional. The tumor functional produces hormones such as gastrin, insulin, somatostatin, glucagon, among others. They are symptomatic due to hormonal hypersecretion and occur in 30% of cases. The other 70% are non-functioning, and despite producing a series of substances and some hormones such as beta HCG and alpha HCG, they are silent tumors, with no significant clinical syndrome. The present study presented scientific evidence about PNETs, the types of pancreas endocrine-tissue tumors, the rate of survival, diagnosis, treatments, and prognosis, to provide solid support to professionals, and contribute to effective decision-making in search of the best clinical outcome.

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Morfologia Do Sistema Urinário Das Aves E Mecanismo De Eliminação Do Sistema Porta Renal - Revisão De Literatura

Goltz,

Barreto,

Lanius

et al. 2023

Veterinária: Desafios E Tendências Da Ciência E Tecnologia 2

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Neuroendocrine tumors: review of the literature

Cited by 4 publications

References 0 publications

Cutaneous Metastasis of Neuroendocrine Carcinoma with Unknown Primary Site: Case Report and Review of the Literature

Cutaneous Metastasis of Neuroendocrine Carcinoma with Unknown Primary Site: Case Report and Review of the Literature

Pancreatic Neuroendocrine Tumors: A Literature Review

Morfologia Do Sistema Urinário Das Aves E Mecanismo De Eliminação Do Sistema Porta Renal - Revisão De Literatura

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