Neuroendocrine Tumors: An Analysis of Prevalence, Incidence, and Survival in a Hospital-Based Study in Ecuador

Escobar, Karime Montes; Villardón, José Luis Vicente; Gonzalez, Rosa Elisa Villacís; Cordova, Paul Humberto Castillo; Rodríguez, Johanna Mabel Sánchez; Cruz-Velez, Melina De la; Siteneski, Aline

doi:10.3390/healthcare10081569

Cited by 4 publications

(3 citation statements)

References 45 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, g-NET demonstrates indolent growth patterns and a propensity towards benign tumor behavior, 40,41 while both g-NEC and g-MiNEN are marked by high malignancy and unfavorable prognostic outcomes. [42][43][44] Our study unveiled that the 5-year survival rates for G1 and G2 were 100% and 80.0%, respectively. By contrast, g-NEC and g-MiNEN exhibited considerably lower rates of 26.7% and 35.2%, respectively.…”

Section: Discussionmentioning

confidence: 62%

“…The prognosis of g‐NET, g‐NEC, and g‐MiNEN is believed to display significant differences. Specifically, g‐NET demonstrates indolent growth patterns and a propensity towards benign tumor behavior, 40,41 while both g‐NEC and g‐MiNEN are marked by high malignancy and unfavorable prognostic outcomes 42–44 . Our study unveiled that the 5‐year survival rates for G1 and G2 were 100% and 80.0%, respectively.…”

Section: Discussionmentioning

confidence: 73%

See 1 more Smart Citation

Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis

Zi,

Ma,

Chen

et al. 2024

Cancer Medicine

View full text Add to dashboard Cite

ObjectiveThis study aimed to explore the clinicopathological characteristics and prognostic implications of gastric neuroendocrine neoplasms (g‐NENs).MethodsA retrospective enrollment of 142 patients diagnosed with g‐NENs was conducted at Zhejiang Cancer Hospital between January 1, 2007 and December 31, 2021. The study compared essential clinicopathological features and survival rates. Additionally, the prognosis of gastric neuroendocrine carcinomas/mixed neuroendocrine–non‐neuroendocrine neoplasms (g‐NEC/MiNEN) were contrasted with those of gastric adenocarcinoma (GAC) and signet ring cell carcinoma (SRCC).ResultsThe study comprised a total of 142 g‐NENs cases, with a male‐to‐female ratio of approximately 2:1. The 5‐year survival rates for g‐NEC and g‐MiNEN were 26.7% and 35.2%, respectively. Corresponding 5‐year survival rates for G1 and G2 were observed at 100% and 80.0%, respectively. g‐NEC/MiNEN showed a significantly worse prognosis compared to g‐NET (p < 0.001). g‐NEC/MiNEN exhibited a poor prognosis compared to GAC (p < 0.001), and within poorly differentiated GAC, g‐NEC/MiNEN demonstrated a worse prognosis (p = 0.007). Additionally, patients receiving postoperative adjuvant therapy exhibited notably prolonged overall survival (OS) in the case of g‐NEC/MiNEN (p = 0.010).ConclusionIn short, the prognosis of g‐NEC/MiNEN was worse than that of g‐NET, GAC and poorly differentiated GAC, but this group benefit from postoperative adjuvant therapy.

show abstract

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 73%

Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis

Zi,

Ma,

Chen

et al. 2024

Cancer Medicine

View full text Add to dashboard Cite

show abstract

“…NENs are defined as epithelial neoplasms with predominant neuroendocrine differentiation that can arise from most organs [ 11 , 12 ]. Previous epidemiological studies showed that NENs occur predominantly in the gastrointestinal tract (53.2%), respiratory system (27.3%), and pancreas (7.3%), followed by considerably less frequent locations such as the ovaries (<1%), breasts (<1%), and urinary system (<1%) [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report

Watanabe¹,

Yoon²,

Yamakawa

et al. 2023

Am J Case Rep

View full text Add to dashboard Cite

Patient: Female, 63-year-old Final Diagnosis: Neuroendocrine tumor Symptoms: None Clinical Procedure: — Specialty: Gastroenterology and Hepatology Objective: Rare disease Background: Various neoplasms, including neuroendocrine neoplasms (NENs), can arise from the presacral space. Most presacral lesions are detected due to symptoms arising from tumor growth. However, diagnosing small, asymptomatic presacral tumors is challenging because of their unique location. Case Report: A 63-year-old woman with chronic hepatitis C underwent follow-up after achieving a sustained virological response. Abdominal ultrasonography revealed multiple new hyperechoic masses in the liver. Physical and laboratory examinations, including tumor marker analysis, yielded unremarkable results. Computed tomography (CT) and magnetic resonance imaging (MRI) indicated metastatic liver tumors but failed to identify the primary site of these lesions. The hepatic mass was biopsied, leading to a diagnosis of grade 2 neuroendocrine tumor. 111 In-pentetreotide somatostatin receptor scintigraphy revealed significant radiotracer accumulation in multiple hepatic masses, several bones, and a small presacral space lesion. Pathological examination of the presacral lesion confirmed a grade 2 neuroendocrine tumor, similar to the hepatic mass. Review of a CT scan performed 4 years earlier indicated a small cyst-like lesion in the presacral space suspected of being a developmental cyst; however, the presence of cystic components was not confirmed pathologically. The patient was diagnosed with a primary presacral neuroendocrine tumor, which might have originated from a developmental cyst, with multiple liver metastases. Chemotherapy with everolimus was initiated, and the clinical course has been uneventful. Conclusions: We report a rare neuroendocrine tumor arising from the presacral space with multiple liver metastases. The presacral space should be examined when a NEN with an unknown primary site is found.

show abstract

Survival of 48866 cancer patients: results from Nantong area, China

Wang,

Xu,

Chen

et al. 2023

Front. Oncol.

View full text Add to dashboard Cite

ObjectiveThis study aimed to provide a realistic observation of survival by major site for 48,866 cancer patients treated at a tertiary cancer hospital in a rural area of China.MethodsPatients with cancer registered between 2007 and 2017 in the Nantong rural area were followed up. The starting date for survival calculation was the date of the first diagnosis of cancer at the Nantong Tumor Hospital, and the closing date was December 31, 2020. Observed survival (OS) was analyzed according to ICD-10 site, sex, age, region, and hospitalization period using the life table method and compared using the Wilcoxon (Gehan) statistic.ResultsThe overall 5-year OS rate was 40.48% for all 48,866 patients, 30.19% for males, and 51.90% for females. The top five cancer sites, accounting for 60.51% of the total cases, were the esophagus, lung, stomach, liver, and cervix, with 5-year OS rates of 33.72%, 18.64%, 32.10%, 19.04%, and 71.51%, respectively. The highest 5-year OS was observed in the thyroid (87.52%) and the lowest was in the pancreas (6.37%). Survival was significantly higher in younger patients than in older patients, with 5-year OSs of 69.26% and 19.84% in those aged 20-29 and 90-99 years, respectively. Five-year OSs improved significantly from 39.35% in 2007-2011 to 41.26% in 2012-2017.ConclusionOverall survival improved over the years, although the improvement at some sites was not significant. The observed survival varies from region to region, reflecting differences in the patterns of major sites, disparities in proportions of hospitalization, and demographic characteristics.

show abstract

Neuroendocrine Tumors: An Analysis of Prevalence, Incidence, and Survival in a Hospital-Based Study in Ecuador

Cited by 4 publications

References 45 publications

Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis

Clinicopathological characteristics of gastric neuroendocrine neoplasms: A comprehensive analysis

Primary Presacral Neuroendocrine Tumor Presenting as Multiple Liver Metastasis: A Case Report

Survival of 48866 cancer patients: results from Nantong area, China

Contact Info

Product

Resources

About