Neuroendocrine tumors: A population-based study of incidence and survival in Girona province, 1994–2004

Epidemiologia nowotworów neuroendokrynnych układu pokarmowego w Krakowie i powiecie krakowskim w latach 2007-2011.

“…A regional register from Girona in Spain (1994Spain ( -2004 reported an even lower GEPNEN incidence of 1.1 [5]. The similarity of incidence rates of GEPNEN in the investigated area with other European countries indicates the good ascertainment of the Department of Endocrinology NEN register.…”

“…For comparison, in the Norwegian population they ranged from 0.16 for appendiceal to 0.81 for small intestinal NEN [7]. In smaller European registers coefficients were lower: in the province of Girona in Spain they ranged from 0.05 for gastric NEN to 0.5 for pancreatic NEN [5], and in Tuscany in Italy they were in the range 0.1-0.3 [10]. In Taiwan the primary location-specific incidence rates ranged from 0.06 for small intestinal NEN to 0.38 for rectal NEN [17].…”

“…GEPNEN epidemiologi- cal studies are difficult due to problems with collection and comparison of data, as well as constantly changing classification systems. Relatively low ascertainment of registers, combined with the fact that sometimes they comprised only neuroendocrine cancers, may cause underestimation of GEPNEN incidence in many databases and publications [5]. The US SEER cancer registry, initiated in 1973, is the largest database of GEPNEN.…”

“…Local European registries based on smaller populations, similar in size to that in our study (approx. 550,000 people), provide only the average incidence rates for the whole studied period, without trend analysis [5].…”

Best prognostic factor of neuroendocrine tumors: Grade or Stage? A multidisciplinary single-center study

“…Using data gathered between 1973 and 2004 from an epidemiological database in the United States, The Surveillance Epidemiology and End Results (SEER) study reports the incidence of NETs as 5.25 per 100.000 persons (2). The incidence and prevalence of these tumors have been increasing in recent decades (3). The observed changes in the incidence and prevalence of NET may be partly due to the rising number of asymptomatic NET cases that are incidentally identified because of the increased availability of modern endoscopic and radiological imaging techniques (4,5).…”