Neuroendocrine Tumor in a Horseshoe Kidney

Motta, L; Candiano, Giuseppe; Pepe, Pietro; Panella, P; Galia, Antonio; Aragona, F

doi:10.1159/000081601

Cited by 12 publications

(3 citation statements)

References 16 publications

(22 reference statements)

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“…Forty‐eight studies were included in our final analysis (Figure 1). These included six registry studies 1,2,6–9 20 analyses of previously published cases, 10–29 and 22 case series 30–51 . The paucity of large cohort or population studies yielded by our literature search is a testament to the extreme rarity of renal NENs.…”

Section: Resultsmentioning

confidence: 99%

“…Renal NET occurring in a horseshoe kidney also appear to be more benign than those occurring in a normal kidney 23 . The calculated relative risk of developing a NET in a horseshoe kidney was reported as 62 by Krishnan et al, 18 120 by Motta et al 19 and 82 by Begin et al 18,19,23 The relative risk of 120 was based on 40 published cases in the literature at the time. Because of the requisite of documenting laterality of the involved kidney on the SEER database, the apparent increased risk of developing renal NET in a horseshoe kidney could be not confirmed in the larger registry studies 2,6 .…”

Section: Resultsmentioning

confidence: 99%

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Primary renal neuroendocrine neoplasms: A systematic literature review, report of four local cases, and original survival analysis of 63 patients from a national registry 2012–2018

Paisey

Weerasuriya

Palmer

et al. 2022

J Neuroendocrinology

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Primary renal neuroendocrine neoplasms (NEN) are rare. We aimed to conduct a systematic review, present local cases, and analyse data from the England's National Cancer Registration and Analysis Service (NCRAS) to provide comprehensive evidence on clinical experience, incidence, and survival to better characterize these tumours. First, a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method; second, a synthesis of local cases; and, finally, a retrospective population-based cohort analysis of renal NEN recorded between 2012 and 2018 on NCRAS were performed. Kaplan-Meier estimator was used to calculate overall survival and Cox proportional hazard regression to identify prognostic factors. Systematic review identified 48 articles and the evidence was summarized and presented. We reported data from four local cases presenting with abdominal and back pain but without carcinoid syndrome. In population-based analysis, we identified 63 cases of renal NEN between 2012 and 2018 from the registry. Age-standardized incidence was 0.09-0.32 per million with a median age of 64 years (interquartile range = 48-72 years). Survival was worse in males and those aged 64 years and over. Five-year survival for renal neuroendocrine tumours (NET) was 69.8% (95% confidence interval = 66.6-72.7) and neuroendocrine carcinomas (NEC) was 38.4% (95% confidence interval = 34.6-42.0). No independent predictive factor was identified in the multivariable analyses. We have given a systematic review of evidence, published local experience, and reported incidence and survival of renal NEN in England for the first time. We have provided clinicians with evidence on diagnosis and proposed a treatment algorithm of theses rare tumours. The incidence and median age of presentation in England is similar to other published series. Renal NET has better survival than renal NEC as expected. A uniform classification system would reduce inconsistencies in reporting and standardize treatment decisions for this neoplasia.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Primary renal neuroendocrine neoplasms: A systematic literature review, report of four local cases, and original survival analysis of 63 patients from a national registry 2012–2018

Paisey

Weerasuriya

Palmer

et al. 2022

J Neuroendocrinology

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“…The relative risk of carcinoid tumours in individuals with horseshoe kidneys compared to individuals with normal kidneys ranges from 62 to 120 [34, 41, 42]. There are 8 cases of primary renal carcinoid tumour associated with horseshoe kidneys in our review [10, 13, 18, 26, 27, 29].…”

Section: Discussionmentioning

confidence: 99%

Primary Carcinoid Tumour of the Kidney: A Review of the Literature

Omiyale

Venyo

2013

Advances in Urology

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Context. Primary renal carcinoid tumours are rare. Their pathogenesis is unknown and the clinical presentation is similar to other renal tumours thus posing diagnostic dilemmas for clinicians. Objectives. To review the literature for case reports of primary renal carcinoids. Methods. Literature was extensively searched for case reports for primary renal carcinoids. Reports of metastatic carcinoids to the kidneys were excluded. Results. Approximately less than 90 cases of primary carcinoid tumours of the kidney have been reported in the literature. A total of 29 cases of primary renal carcinoids were reviewed. The mean age of presentation was 48 years (range 29–75) with both right kidney (48.3%) and left kidney (44.8%) being equally affected. 28.6% of the cases reviewed were diagnosed as an incidental finding. The mean followup time was 20 months with 73.1% of patients without evidence of disease after surgical treatment (radical or partial nephrectomy). Primary carcinoid tumours of the kidney are often well differentiated tumours. They are often misdiagnosed because of their rarity and similar presentation with other renal tumours. Conclusions. Primary carcinoid tumours of the kidney are rare tumours with an indolent course with frequent metastasis. Metastatic work up and followup is required in their management.

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