Neuroendocrine tumor arising from tailgut cyst with spinal cord tethering: case report and literature review

Mitsuyama, Tetsuryu; Kubota, Motoo; Nakamura, Yoshiaki; Yuzurihara, Mitsutoshi; Hoshi, Kazuei; Okada, Yoshikazu

doi:10.1016/j.spinee.2014.09.027

Cited by 22 publications

(33 citation statements)

References 21 publications

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“… reported three of seven benign appearing cysts misdiagnosed by preoperative biopsy. There have been cases of what was deemed initially to be a benign presacral cyst found on the final pathology to contain adenocarcinoma and carcinoid . There have been around 16 cases of carcinoid within a tailgut cyst described in the literature .…”

Section: Resultsmentioning

confidence: 99%

“…Benign tumours such as tailgut cysts may progress to become neuroendocrine tumours or adenocarcinoma, teratomas have a high risk of malignant transformation, and myelipomas have been described in the literature to harbour malignancy despite a benign appearance. Benign appearing tumours may contain malignancy on pathological evaluation . There are many approaches to the management of presacral tumours, and this review assesses the available evidence in the current literature that deals with its preoperative investigations, surgical strategies and neoadjuvant and adjuvant therapies.…”

Section: Introductionmentioning

confidence: 99%

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Management approach and surgical strategies for retrorectal tumours: a systematic review

Toh

Morgan

2016

Colorectal Disease

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Management approach and surgical strategies for retrorectal tumours: a systematic review

Toh

Morgan

2016

Colorectal Disease

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“…Hjermstad and Helwig [1] were among the first to cogently raise the concern that lesions in this area therefore cannot be assumed to arise from tailgut. Certainly a number of neuroendocrine tumours have been reported arising from tailgut cysts [47,49,61,64,93,103,137], but endoderm is known to be capable of generating neuroendocrine cells [138,139].…”

Section: Discussionmentioning

confidence: 99%

“…It seems reasonable to exclude those cases where there was evidence of invasion of the spinal canal and in some cases even tethering of the spinal cord in association with pre-sacral cysts, since these violate the embryological planes respected by all other enteric structures. However, we found only five such cases [137,[140][141][142]145], one of which also had inferior vena cava duplication and uterine didelphys [141]. We are anxious to exclude these cases because a true ontogenic explanation for them does not exist.…”

Section: Pathologymentioning

confidence: 99%

Malignant transformation of tailgut cysts is significantly higher than previously reported: systematic review of cases in the literature

et al. 2019

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Aim The best treatment for tailgut cysts has not been firmly established. We report a systematic review of the cases in the available literature in order to provide an evidence base for treatment. Method A systematic search of articles wholly or partly in English was made of PubMed, Embase and Google Scholar; additional studies were discovered by searching reference lists and contacting authors directly. Search terms ‘tailgut cyst’, ‘tail gut cyst’, ‘retrorectal hamartoma’ and ‘retrorectal tumour’ were used for case reports or case series; no publication date restrictions were imposed. Only studies with histological confirmation of diagnosis and reporting the age and gender of patients were included. Papers were excluded by consensus between the first two authors. Results A total of 196 individual cases were analysed in detail including 51 cases of neoplasia. The overall rate of neoplastic transformation was 26.6%. Although the male:female cyst incidence ratio was 1:4, men over 18 had a significantly greater relative risk of neoplasm at 1.94 (P = 0.0055). Radiological evidence of nodular thickening of the cyst wall significantly increased the relative risk of the presence of cancer (P = 0.0023). Conclusions Current orthodoxy that these are not dangerous embryological remnants is unfounded and may be false. The available data suggest the risk of malignant transformation is high and will apply to any residual tissue after excision. The same rationale behind total mesorectal excision in rectal cancer applies to tailgut cysts. Consequently they should be resected with similar oncological margins.

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“…According to the NET 5-grade criteria published by the World Health Organization in 2014 (Mitsuyama et al, 2015), 28 patients were grade one, 36 grade two, 64 grade three, 40 grade four, 40 grade 5, and 36 grade 6. Grade 1-3 was defined as low level of NETs and grand 4-6 was defined as high level of NETs.…”

Section: Sampling Of Net Subjectsmentioning

confidence: 99%

Effect of everolimus on the expression of Ki-67 and caspase-3 in patients with neuroendocrine tumors

Zhang

Cheng

et al. 2017

Genet. Mol. Res.

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ABSTRACT. Tumors, especially neuroendocrine tumors (NETs), can cause adverse effects on human health. The expression and significance of Ki-67 and caspase-3 in NET remain to be further explored. Everolimus is an important drug used for the treatment of NETs. In this study, we aimed to investigate whether everolimus exerts anti-tumor effects by suppressing the expression of Ki-67 and caspase-3 in NET. Tumor (different developmental stages) and adjacent tissues were collected from patients with NET. The expression of Ki-67 and caspase-3 were detected in 244 paraffin sections of NET using immunohistochemistry. RT-PCR and western blot were used to detect the expression of Ki-67 and caspase-3 at mRNA and protein levels, respectively. The patients (N = 244) were randomly divided into everolimus-intervention and control groups. RT-PCR and western blot were used to measure the expression changes of Ki-67 and caspase-3 before and after everolimus treatment. The rates of Ki-67 expression in NET grades 1-6 were 14.2, 22.1, 37.5, 59.9, 69.9, and 77.8%, respectively. The difference between the groups was significant. The rates of caspase-3 expression in NET grades 1-6 were 28.6, 33.3, 31.3, 60.0, 80.0, and 88.9%, respectively, and the difference between groups was significant. Moreover, the expression of Ki-67 and caspase-3 showed a significant negative correlation. The expression of Ki-67 decreased while that of caspase-3 increased after everolimus treatment. In conclusion, the decrease in Ki-67 expression and increase in caspase-3 expression after everolimus treatment indicated that everolimus exerted its anti-cancer effect by regulating the expression of Ki-67 and caspase-3.

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Neuroendocrine tumor arising from tailgut cyst with spinal cord tethering: case report and literature review

Cited by 22 publications

References 21 publications

Management approach and surgical strategies for retrorectal tumours: a systematic review

Management approach and surgical strategies for retrorectal tumours: a systematic review

Malignant transformation of tailgut cysts is significantly higher than previously reported: systematic review of cases in the literature

Effect of everolimus on the expression of Ki-67 and caspase-3 in patients with neuroendocrine tumors

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