Neuroendocrine Targets for the Treatment of Obesity: Physiological Roles and Unrealized Opportunities

Harrold, Jo; Williams, G.; Wong, Stephen Phooi Yew

doi:10.2174/1568015033477785

Cited by 4 publications

(1 citation statement)

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“…Obesity is becoming one of the largest threats to world health in this millennium, with more than one billion adults with excess weight (Harrold et al, 2003;Arbeeny, 2004). Discoveries towards the understanding of the molecular mechanisms that regulate body weight have provided potential opportunities for intervention with therapeutic ends and give renewed hope for the development of antiobesity drugs (Foster-Schubert & Cummings, 2006).…”

Section: Introductionmentioning

confidence: 99%

Inhibition of pancreatic lipase by extracts of Baccharis trimera (Less.) DC., Asteraceae: evaluation of antinutrients and effect on glycosidases

Souza¹,

Pereira²,

Souza³

et al. 2011

Rev. bras. farmacogn.

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Abstract:In order to confirm the traditional use of Baccharis trimera (Less.) DC., Asteraceae, for the reduction of weight, plant extracts were evaluated on the activity of pancreatic lipase (PL), an enzyme responsible for hydrolysis of triacylglycerols in the diet for its subsequent absorption. The aqueous and infused extracts did not show inhibitory activity on the PL, the ethanol inhibited 16% (66 ALI/g) and methanol extract inhibited 78% (241 ALI/g). The methanol extract of B. trimera (MEB) was subjected to a wash with decreasing solvent polarity (n-hexane, ethyl acetate and methanol) and only the methanol fraction inhibited the lipase by 72% (230 ALI/g). We evaluated the MEB and infused inhibitory activity on the enzymes α-amylase and α and β-glycosidases. The α-amylase was not inhibited by any of the extracts, the enzyme α-glucosidase was inhibited by both extracts in the same proportion (46.9±0.1) and β-glucosidase was inhibited by 73% by the methanol extract and 65% by the infused. We also evaluated the presence of anti-nutrients. We detected the presence of saponins, polyphenols and trypsin inhibitors in the two samples. Tests performed in vivo can assess at which therapeutic concentration the presence of these anti-nutrients can be harmful to health.

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Section: Introductionmentioning

confidence: 99%

Inhibition of pancreatic lipase by extracts of Baccharis trimera (Less.) DC., Asteraceae: evaluation of antinutrients and effect on glycosidases

Souza¹,

Pereira²,

Souza³

et al. 2011

Rev. bras. farmacogn.

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Immobilization of porcine pancreatic lipase onto a metal-organic framework, PPL@MOF: A new platform for efficient ligand discovery from natural herbs

Chen

Xue

Lin

et al. 2020

Analytica Chimica Acta

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Up-regulation of NPY gene expression in hypothalamus of rats with experimental chronic renal failure

Sucajtys-Szulc

Karbowska

Kochan

et al. 2007

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Anorexia is possibly one of the most important causes of malnutrition in uremic patients. The cause of this abnormality is still unknown. Considering that: (a) NPY is one of the most important stimulants of food intake; (b) eating is a central nervous system regulated process and (c) NPY is expressed in hypothalamus, we hypothesized that the decrease of NPY gene expression in the hypothalamus could be an important factor contributing to anorexia associated with uremic state. In contrast to the prediction, the results presented in this paper indicate that the NPY gene expression in the hypothalamus of chronic renal failure (CRF) rats was significantly higher than in the hypothalamus of control (pair-fed) rats. Moreover, we found that serum NPY concentration in CRF rats was higher than in control (pair-fed) animals. The increase of plasma NPY concentration in CRF rats may be due to the greater synthesis of the neuropeptide in liver, since higher level of NPY mRNA was found in liver of CRF rats. The results obtained revealed that experimental chronic renal failure is associated with the increase of NPY gene expression in hypothalamus and liver of rats.

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Neuroendocrine Targets for the Treatment of Obesity: Physiological Roles and Unrealized Opportunities

Cited by 4 publications

References 0 publications

Inhibition of pancreatic lipase by extracts of Baccharis trimera (Less.) DC., Asteraceae: evaluation of antinutrients and effect on glycosidases

Inhibition of pancreatic lipase by extracts of Baccharis trimera (Less.) DC., Asteraceae: evaluation of antinutrients and effect on glycosidases

Immobilization of porcine pancreatic lipase onto a metal-organic framework, PPL@MOF: A new platform for efficient ligand discovery from natural herbs

Up-regulation of NPY gene expression in hypothalamus of rats with experimental chronic renal failure

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