“…The hypothalamus receives afferent neural and humoral signals from the injured area and integrates this input to provide an adequate response, which includes pituitary and sympathetic stimulation [1]. The magnitude of this stress response depends on a variety of factors such as severity [2] and duration of surgical trauma [3,4], patient age [5], intraoperative blood loss [6], postoperative pain [7], anesthetic method [8], and surgical technique [9].…”