Neuroendocrine Responses to Stress in Mice: Hyporesponsiveness in Pregnancy and Parturition

Douglas, Alison J.; Brunton, Paula; Bosch, Oliver J.; Russell, John A.; Neumann, Inga D.

doi:10.1210/en.2003-0461

Cited by 113 publications

(108 citation statements)

References 60 publications

(83 reference statements)

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…However, the corticosterone levels were higher in immunechallenged nonpregnant rats compared with late-term pregnant rats (5). This observation explains why the activation of HPA axis is also dampened at near term (14).…”

Section: Discussionmentioning

confidence: 88%

“…The HPA axis activation results in the production of the antipyretic/anti-inflammatory corticosterone. The fact that basal HPA activity is specifically enhanced at near term (3,14) led us to explore the importance of HPA involvement in the observed fever reduction at near term. In the present study, there was no difference in LPS-stimulated circulating free corticosterone levels of pregnant and lactating rats.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, there was no difference in LPS-stimulated circulating free corticosterone levels of pregnant and lactating rats. In addition, late pregnancy is already known to be associated with a reduced HPA response to emotional stress (14,55). Therefore, neither possible emotional stress response to the injection nor the immune stimulation itself extraordinarily enhances HPA activity at term that could account for the reduced fever.…”

Section: Discussionmentioning

confidence: 99%

“…The basal HPA activity, and consequently the production of corticosteroids, was specifically enhanced at near term (3,14). We therefore explored whether the corticosterone response to LPS was also altered in near-term pregnant rats, which could account for the fever suppression.…”

Section: Activation Of Nf-b Pathway At Near Term Nf-b Is Normally Sementioning

confidence: 99%

“…On the other hand, it is well known that the basal hypothalamic-pituitary-adrenal (HPA) activity, and consequently the plasma levels of corticosteroids, are significantly enhanced at near term (3,14). Because corticosteroids attenuate the febrile response (48), we tested whether plasma corticosterone levels are also altered in immune-challenged near-term pregnant rats.…”

mentioning

confidence: 98%

See 4 more Smart Citations

Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways

Mouihate¹,

Ellis²,

Harré³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

pregnant rats show a suppressed fever response to LPS that is associated with reduced induction of cyclooxygenase (COX)-2 in the hypothalamus. The objective of this study is to explore whether the LPS-activated signaling pathways in the fever-controlling region of the hypothalamus are specifically altered at near term. Three rat groups consisting of 15-day pregnant rats, near-term 21-to 22-day pregnant rats, and day 5 lactating rats were injected with a febrile dose of LPS (50 g/kg ip). The hypothalamic preoptic area and the organum vasculosum of the lamina terminalis (OVLT) were collected 2 h after LPS injection. The activation of three transcription modulators, nuclear factor-B (NF-B), extracellular signal-regulated kinase 1/2 (ERK1/2), and signal transducer and activator of transcription 5 (STAT5), was assessed using semiquantitative Western blot analysis. LPS activated the NF-B pathway in all rat groups, and this response was not altered at near term. ERK1/2 and STAT5 were constitutively activated during all reproductive stages, and their levels were not significantly affected by LPS injection. Plasma levels of the proinflammatory cytokines (IL-1␤, IL-6, TNF-␣, and IFN-␥), anti-inflammatory cytokines (IL-4, IL-10, and IL-1 receptor antagonist), and corticosterone were unaffected during the three reproductive stages after LPS challenge. We observed a sharp decrease in the expression of a prostaglandinproducing enzyme called lipocalin-prostaglandin D 2 synthase in nearterm pregnant and lactating rats. Thus fever suppression at near term is not due to an alteration in either LPS-activated intracellular signaling pathways or LPS-induced pro-and anti-inflammatory cytokine production.reproduction; cytokine; nuclear factor-B; extracellular signal-regulated kinase 1/2; signal transducer and activator of transcription 5

show abstract

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Activation Of Nf-b Pathway At Near Term Nf-b Is Normally Sementioning

confidence: 99%

mentioning

confidence: 98%

See 3 more Smart Citations

Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways

Mouihate¹,

Ellis²,

Harré³

et al. 2005

American Journal of Physiology-Regulatory, Integrative and Comp

View full text Add to dashboard Cite

show abstract

Neonatal handling alters maternal emotional response to stress

Reis

Jacobs

Menegotto

et al. 2016

Developmental Psychobiology

View full text Add to dashboard Cite

Neonatal handling is an experimental procedure used to analyze the effects of environmental interventions during early postpartum days (PPD). Long-lasting effects of repeated stress exposure in the neonatal period on the maternal side are poorly studied in this model. The aim of this study was to verify if handling the pups induces enduring effects on damśstress responses, increasing their risk for depression. Dams were divided into two groups (NH-Non-handled and H-Handled) based on the handling procedure (pups were handled for 1 min/per day from PPD1-PPD10) and then subdivided into four groups (NH, NH + S, H, and H + S) based on the exposure or not to restraint stress after weaning (1 hr/per day for 7 days, PPD22-PPD28). We analyzed damśbehavior in the forced swimming test (FST PPD29-PPD30), plasma basal corticosterone and BDNF levels, as well as adrenal weight (PPD31). The results show that handling alters the stress response of dams to acute and chronic stress, as evidenced by dams of the H group having increased immobility in the first day of FST (p < .001), similar to NH + S (p < .01). Dams of the H and H + S groups show decreased levels of corticosterone when compared to NH and NH + S groups (p < .05), but the H + S group shows an increased adrenal weight, suggesting an increased sensibility of the maternal organism to the chronic stress applied after weaning (p < .05). We show that handling may induce a long-lasting effect on maternal stress response; these changes in the damśemotional reactivity increase their susceptibility for the development of psychiatric disorders such as depression. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58: 614-622, 2016.

show abstract

Maternal experience inhibits the production of immature neurons in the hippocampus during the postpartum period through elevations in adrenal steroids

et al. 2007

View full text Add to dashboard Cite

Motherhood is accompanied by alterations in numerous nonreproductive behaviors, including learning and memory, as well as anxiety and stress regulation. These functions have been linked to adult neurogenesis in the hippocampus, but the effect of maternal experience on this brain region has not been completely explored. To determine whether the production of new hippocampal granule cells is altered during the postpartum period, we examined the number of proliferating cells and their progeny in the dentate gyrus of primiparous female rats at various time points during the postpartum period while they were caring for their offspring, as well as after weaning. Additionally, we investigated whether cell proliferation in the postpartum female is affected by the presence of offspring and nursing-induced increases in glucocorticoids. Analysis of the number of BrdU-labeled cells revealed that cell proliferation in the dentate gyrus was suppressed in lactating postpartum females until the time of weaning. This effect was temporary; a difference was detectable at 1 week after BrdU-labeling, when the majority of cells expressed a marker of immature and mature granule neurons (TuJ1) but not at 2 weeks, when most cells expressed a marker of mature neurons (NeuN). The decrease in cell proliferation was dependent on elevated basal glucocorticoid levels associated with lactation; removal of nursing pups reduced basal corticosterone levels and prevented the decrease in the number of BrdU-labeled cells. Moreover, preventing increased basal corticosterone levels by means of adrenalectomy and low-dose corticosterone replacement eliminated the reduction in cell proliferation. These findings indicate that offspring interactions inhibit adult neurogenesis through changes in adrenal steroids, and further suggest a potential mechanism for alterations in hippocampal function during the postpartum period.

show abstract

Neuroendocrine Responses to Stress in Mice: Hyporesponsiveness in Pregnancy and Parturition

Cited by 113 publications

References 60 publications

Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways

Fever suppression in near-term pregnant rats is dissociated from LPS-activated signaling pathways

Neonatal handling alters maternal emotional response to stress

Maternal experience inhibits the production of immature neurons in the hippocampus during the postpartum period through elevations in adrenal steroids

Contact Info

Product

Resources

About