Neuroendocrine response to casino gambling in problem gamblers

Meyer, Gerhard; Schwertfeger, Jan; Exton, Michael S.; Janßen, Onno E.; Knapp, Wolfram; Städler, Michael; Schedlowski, Manfred; Krüger, Tillmann H.C.

doi:10.1016/j.psyneuen.2004.03.005

Cited by 171 publications

(96 citation statements)

References 30 publications

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“…Second, under placebo, the slot machine game primed Desire to Gamble and increased systolic blood pressure in controls. This latter finding is consistent with the previously noted findings of elevated sympatho-adrenal responses in problem and non-problem gamblers during casino gambling (Meyer et al, 2004). Finally, haloperidol augmented the pressor effects of the game in controls and the magnitude of the drug effect was quite similar to that of gamblers.…”

Section: Discussionsupporting

confidence: 92%

“…Other work has found that engaging in actual casino gambling elevates activity of the hypothalamic-pituitary axis in problem and non-problem gamblers, as reflected by increased plasma levels of norepinephrine, cortisol, and a concomitant increase in heart rate (Meyer et al, 2004). In addition, casino gambling led to elevated dopamine levels in both groups, with higher levels emerging in the problem gamblers.…”

Section: Introductionmentioning

confidence: 86%

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A D2 Antagonist Enhances the Rewarding and Priming Effects of a Gambling Episode in Pathological Gamblers

Zack

Poulos

2007

Neuropsychopharmacol

152

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Previous research indicated shared neurochemical substrates for gambling and psychostimulant reward. This suggests that dopamine substrates may directly govern the reinforcement process in pathological gambling. To investigate this issue, the present study assessed the effects of the relatively selective dopamine D2 antagonist, haloperidol (3 mg, oral) on responses to actual gambling (15 min on a slot machine) in 20 non-comorbid pathological gamblers and 18 non-gambler controls in a placebo-controlled, double-blind, counterbalanced design. In gamblers, haloperidol significantly increased self-reported rewarding effects of gambling, post-game priming of desire to gamble, facilitation of reading speed to Gambling words, and gambling-induced elevation in blood pressure. In controls, haloperidol augmented gambling-induced elevation in blood pressure, but had no effect on other indices. The findings provide direct experimental evidence that the D2 substrate modulates gambling reinforcement in pathological gamblers.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 86%

A D2 Antagonist Enhances the Rewarding and Priming Effects of a Gambling Episode in Pathological Gamblers

Zack

Poulos

2007

Neuropsychopharmacol

152

View full text Add to dashboard Cite

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“…Alternatively, the impairment observed after 8-OH-DPAT may relate to the anxiogenic properties of the drug (File et al, 1996). Certainly, stress and anxiety can contribute to maladaptive gambling behavior (Black and Moyer, 1998;Meyer et al, 2000;Meyer et al, 2004), although whether anxiolytic agents would improve rGT performance remains to be determined.…”

Section: Serotonergic Modulation Of Rgt Performancementioning

confidence: 99%

“…Serotonin (5-HT) and dopamine (DA) play important roles in impulsivity and addiction (Pattij and Vanderschuren, 2008), and current data suggest that they also contribute to PG; patients with Parkinson's disease (PD) treated with DA agonists can develop symptoms of PG (Weintraub et al, 2006), and peripheral measures of DA are elevated when both healthy and problem gamblers gamble (Meyer et al, 2004;Shinohara et al, 1999). In contrast, decreases in peripheral measures of 5-HT have been observed in pathological gamblers (Marazziti et al, 2008;Pallanti et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Serotonergic and Dopaminergic Modulation of Gambling Behavior as Assessed Using a Novel Rat Gambling Task

Zeeb

Robbins

Winstanley

2009

Neuropsychopharmacol

317

446

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Pathological gambling (PG) is characterized by persistent, maladaptive gambling behavior, which disrupts personal and professional life. Animal models of gambling behavior could make a significant contribution to improving our understanding of the neural and neurochemical basis of gambling, and the treatment of PG. When gambling, failing to win critically results in the loss of resources wagered as well as the absence of additional gain. Here, we have incorporated these concepts into a novel rat gambling task (rGT), based, in part, on the 'Iowa' gambling task (IGT) commonly used clinically to measure gambling-like behavior. Rats choose among four different options to earn as many sugar pellets as possible within 30 min. Each option is associated with the delivery of a different amount of reward, but also with a different probability and duration of punishing time-out periods during which reward cannot be earned. The schedules are designed such that persistent choice of options linked with larger rewards result in fewer pellets earned per unit time. Rats learn to avoid these risky options to maximize their earnings, comparable with the optimal strategy in the IGT. Both d-amphetamine and the 5-HT 1A receptor agonist, 8-OH-DPAT, impaired task performance. In contrast, the dopamine D 2 receptor antagonist, eticlopride, improved performance, whereas the D 1 receptor antagonist, SCH23390, had no effect. These data suggest that both serotonergic and dopaminergic agents can impair and improve gambling performance, and indicate that the rGT will be a useful tool to study the biological basis of gambling.

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“…Peripheral measures of DA have been observed to be elevated in problem gamblers during casino gambling 24 and in people playing Pachinko, a form of gaming combining elements of pinball and slot machines. 25 Data on central DA function in PG indicate abnormalities including altered CSF levels of DA (decreased) and its metabolite 3,4-dihydroxyphenylacetic acid (DHPA) (increased), together suggesting an increase in DA neurotransmission.…”

mentioning

confidence: 99%

Neurobiologia dos transtornos do controle dos impulsos

Williams

Potenza

2008

Rev. Bras. Psiquiatr.

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A b s t r a c t Objective: To review the neurobiological substrates of impulse control disorders. Pathological gambling is a main focus of the review in that most biological studies of the formal impulse control disorders have examined this disorder. Method: The medical database Medline from 1966 to present was searched to identify relevant articles that were subsequently reviewed to generate this manuscript. Results: Preclinical studies suggest that differential brain monoamine neuromodulation is associated with impulsive decision-making and risk-taking behaviors. Clinical studies implicate multiple neurotransmitter systems (serotonergic, dopaminergic, adrenergic, and opioidergic) in the pathophysiology of pathological gambling and other impulse control disorders. Initial neuroimaging studies have implicated the ventromedial prefrontal cortex and ventral striatum in the pathophysiology of pathological gambling and other impulse control disorders. Genetic contributions to pathological gambling seem substantial and initial studies have implicated specific allelic polymorphisms, although genome-wide analyses have yet to be published. Conclusion: Although significant advances have been made in our understanding of the neurobiology of impulse control disorders, more research is needed to extend existing knowledge and translate these findings into clinical advances.Descriptors: Pathological gambling; Serotonin; Norepinephrine; Dopamine; Opioids Resumo Objetivo: Revisar os artigos sobre substratos neurobiológicos dos transtornos do controle do impulso. O jogo patológico é o foco central desta revisão na medida em que a maioria dos estudos biológicos dos formalmente classificados como transtornos do controle do impulso examinou este transtorno. Método: Foi feita uma busca no banco de dados Medline de artigos publicados de 1966 até o presente para identificar aqueles relevantes para serem revisados neste artigo. Resultados: Estudos pré-clínicos sugerem que a neuromodulação das monoaminas cerebrais está associada à tomada de decisões impulsivas e aos comportamentos de risco. Os estudos clínicos implicam diversos sistemas de neurotransmissores (serotoninérgico, dopaminérgico, adrenérgico e opióide) na fisiopatologia do jogo patológico e de outros transtornos do controle do impulso. Estudos de neuroimagem preliminares têm indicado o córtex pré-frontal ventromedial e o estriato ventral como atuantes na fisiopatologia do jogo patológico e de outros transtornos do controle do impulso. As contribuições genéticas para o jogo patológico parecem substanciais e os estudos iniciais têm relacionado esse transtorno a polimorfismos alélicos específicos, ainda que os achados de varredura genômica ainda tenham que ser publicados. Conclusão: Mesmo que tenham sido logrados avanços significativos em nossa compreensão sobre os transtornos do controle do impulso, mais pesquisas são necessárias para ampliar o conhecimento existente e traduzir esses achados em avanços clínicos.

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Neuroendocrine response to casino gambling in problem gamblers

Cited by 171 publications

References 30 publications

A D2 Antagonist Enhances the Rewarding and Priming Effects of a Gambling Episode in Pathological Gamblers

A D2 Antagonist Enhances the Rewarding and Priming Effects of a Gambling Episode in Pathological Gamblers

Serotonergic and Dopaminergic Modulation of Gambling Behavior as Assessed Using a Novel Rat Gambling Task

Neurobiologia dos transtornos do controle dos impulsos

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