Neuroendocrine Regulation of Male Sexual Behavior

Hull, Elaine M.; Domínguez, Juan M.

doi:10.1002/cphy.c180018

Cited by 15 publications

(11 citation statements)

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“…Differential effects of circulating steroids between sexes e.g., estrogen in females and testosterone in males, potentially underly sexually dimorphic features of the MPOA. Interestingly, whereas some sexually dimorphic features, including cell density and connectivity, are determined predominantly by the presence or absence of the perinatal testosterone surge (organizational effects), the maintenance of neuronal circuitry mediating sexually dimorphic reproductive behaviors requires intact levels of circulating sex hormones during adulthood (activational effects) (Gegenhuber and Tollkuhn, 2020; Hull and Dominguez, 2019; McCarthy et al, 2017; Nugent et al, 2015; Wu et al, 2009; Xu et al, 2012). As the levels of circulating sex steroids start to rise and incrementally approach those of adults during puberty, hormone-dependent alterations of neuronal circuitry gradually mature, as observed in cortical and subcortical areas (Afroz et al, 2016; Piekarski et al, 2017; Sigl-Glöckner et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Pubertal sex hormones control transcriptional trajectories in the medial preoptic area

Hashikawa

Liu

et al. 2021

Preprint

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Pubertal maturation aids development of emotion, cognition, and reproduction. We investigated transcriptional dynamics in the medial preoptic area (MPOA), a hypothalamic center for reproductive behaviors, in male and female mice at single-cell resolution (scRNAseq) during puberty. Defined subsets of neurons expressing Slc32a1 and Esr1 (Vgat+ Esr1+) were the most transcriptionally dynamic compared to other cell types throughout puberty. These cell type specific transcriptional progressions towards adulthood were bidirectionally controlled by the levels of circulating testosterone and estradiol. Selective deletion of Esr1 in Slc32a1-expressing cells in the MPOA prior to puberty arrested transcriptional progression and revealed a sexually dimorphic gene-regulatory network governed by Esr1. Deletion of Esr1 in Vgat+ cells prevented the development of mating behavior in both sexes. These analyses reveal both sexually common and dimorphic transcriptional progressions during puberty as well as their regulatory mechanisms, which have important implications towards understanding adaptative and maladaptive processes governing adolescent brain development.

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Section: Introductionmentioning

confidence: 99%

Pubertal sex hormones control transcriptional trajectories in the medial preoptic area

Hashikawa

Liu

et al. 2021

Preprint

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“…The medial nucleus of amygdala (MeA) had been proved to play an important role in sexual behavior. Previous studies on rats and gerbils had shown that MeA and bed nucleus of the stria terminalis had enhanced c-Fos expression through olfactory pathways, especially the vomeronasal-accessory olfactory system, which in turn activated the medial preoptic area, and finally led to ejaculation ( Veening and Coolen, 1998 , 2014 ; Hull and Dominguez, 2007 , 2019 ; Dhungel et al, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Abnormal Functional Connectivity Between the Left Medial Superior Frontal Gyrus and Amygdala Underlying Abnormal Emotion and Premature Ejaculation: A Resting State fMRI Study

Zhang

Xiang

et al. 2021

Front. Neurosci.

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IntroductionPremature ejaculation (PE) is a common sexual dysfunction and is found to be associated with abnormal emotion. The amygdala plays an important role in the processing of emotion. The process of ejaculation is found to be mediated by the frontal-limbic neural circuits. However, the correlations between PE and emotion are still unclear.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) data were acquired in 27 PE patients with stable emotion (SPE), 27 PE patients with abnormal emotion (NPE), and 30 healthy controls (HC). We used rs-fMRI to explore the underlying neural mechanisms in SPE, NPE, and HC by measuring the functional connectivity (FC). Differences of FC values among the three groups were compared when choosing bilateral amygdala as the regions of interest (ROIs). We also explored the correlations between the brain regions showing altered FC values and scores of the premature ejaculation diagnostic tool (PEDT)/Eysenck Personality Inventory about neuroticism (EPQ-N) in the PE group.ResultsWhen the left amygdala was chosen as the ROI, the SPE group exhibited an increased FC between the left medial superior frontal gyrus (SFGmed) and amygdala compared with the NPE or HC group. When the right amygdala was chosen as the ROI, the NPE group exhibited a decreased FC between the left SFGmed and right amygdala compared with the HC group. In addition, FC values of the left SFGmed had positive correlations with PEDT and negative correlations with EPQ-N scores in the PE group. Moreover, FC values of the left superior temporal gyrus had positive correlations with EPQ-N scores in the PE group.ConclusionThe increased FC values between the left SFGmed and amygdala could reflect a compensatory cortical control mechanism with the effect of stabilized emotion in the limbic regions of PE patients. Abnormal FC between these brain regions could play a critical role in the physiopathology of PE and could help us in dividing PE into more subtypes.

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“…mPOA also innervates the PVN and the VMH , which in turn project on mPOA, constituting a feedback loop (Canteras et al, 1994;Geerling et al, 2010) involved in the regulation of sexual behavior (Argiolas and Melis, 2004;Flanagan-Cato, 2011;Geerling et al, 2010). Finally, the mPOA is capable of activating the reward circuit via its projections onto the ventral tegmental area (VTA) (Tobiansky et al, 2016), providing an anatomic basis for the reinforcing aspects of sexual behavior (Hull and Dominguez, 2019;Pitchers et al, 2010a;Tobiansky et al, 2013).…”

Section: Organization Of the Control Circuit Governing Male Sexual Be...mentioning

confidence: 99%

Hypothalamic cellular and molecular plasticity linked to sexual experience in male rats and mice

Jean

Mhaouty-Kodja

Hardin‐Pouzet

2021

Frontiers in Neuroendocrinology

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Neuroendocrine Regulation of Male Sexual Behavior

Cited by 15 publications

References 314 publications

Pubertal sex hormones control transcriptional trajectories in the medial preoptic area

Pubertal sex hormones control transcriptional trajectories in the medial preoptic area

Abnormal Functional Connectivity Between the Left Medial Superior Frontal Gyrus and Amygdala Underlying Abnormal Emotion and Premature Ejaculation: A Resting State fMRI Study

Hypothalamic cellular and molecular plasticity linked to sexual experience in male rats and mice

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