Neuroendocrine neoplasms of the larynx: Advances in identification, understanding, and management

Ferlito, Alfio; Devaney, Kenneth O.; Rinaldo, Alessandra

doi:10.1016/j.oraloncology.2006.01.002

Cited by 96 publications

(123 citation statements)

References 258 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…On the other side Ramsey concludes that a carcinoid tumor of the middle ear is the appropriate term and should be considered as a distinct entity from the MEA [10]. Middle ear carcinoid was reported to have a metastatic potential, so it should be considered as a low-grade malignancy [10,17,18]. Some have suggested using neuroendocrine adenoma of the middle ear as a more descriptive term [8,19].…”

Section: Classificationmentioning

confidence: 99%

Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series

Saliba¹,

Evrard²

2009

Cases J

View full text Add to dashboard Cite

Introduction: Middle ear glandular neoplasms are infrequent causes of a middle ear mass. They can have exocrine and/or neuroendocrine differentiation. It is currently thought that these tumors are indistinguishable each from another. Herein, we present a new case of a middle ear glandular neoplasm. Our objective is to review all cases described in the literature in order to identify the clinical features, the gross pathology, the histopathology, the immunohistochemistry, to discuss the differential diagnosis, the treatment, the rate of recurrence, the follow-up, the incidence of metastasis, the prognosis and to present a new classification of middle ear glandular neoplasm.

show abstract

Section: Classificationmentioning

confidence: 99%

Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series

Saliba¹,

Evrard²

2009

Cases J

View full text Add to dashboard Cite

show abstract

“…Some researchers have proposed that NECs originate from neuroendocrine cells located at the basal layer of the oral squamous epithelium [9] [18] [21]. Another The differential diagnosis of basaloid-like carcinomas of the head and neck included BSCC, high-grade NEC, and poorly differentiated SCC.…”

Section: Discussionmentioning

confidence: 99%

Primary Neuroendocrine Carcinoma Combined with Squamous Cell Carcinoma of the Soft Palate: A Case Report and Review of Literature

Udompatanakorn¹,

Yada²,

Ishikawa³

et al. 2018

OJST

View full text Add to dashboard Cite

Background: Neuroendocrine carcinomas (NECs) are rare neoplasms that widely occur in various organs. They are heterogeneous and vary from low to high grade malignant. NEC presenting with a squamous cell carcinoma (SCC) component is referred to as a composite tumor. Thus far, few cases of this composite tumor in the oral cavity have been reported in the literature; thus, the histogenesis remains unclear. Case Presentation: We encountered a rare case of a primary NEC combined with SCC, occurring at the soft palate in a 59-year-old man. A resected specimen of the tumor was composed of two components: NEC and SCC. The NEC area contained small round to oval atypical cells arranged in nests with a glandular-like-pattern, hyperchromatic molded nuclei, a high nuclear-to-cytoplasmic ratio, and a scant eosinophilic cytoplasm. The SCC area was composed of non-keratotic, dysplastic oval to spindle-shaped squamous cells with indistinct cell borders and large nuclei that were hyperchromatic and pleomorphic. Immunohistochemically, the tumor cells of the NEC component were positive for chromagranin A, synaptophysin, CD56, and p16, whereas those of the SCC component were positive for 34βE12, p63, and p16. Conclusion: In consideration of the morphological and immunohistochemical results, the final diagnosis was a primary NEC combined with SCC of the soft palate.

show abstract

“…To date, ~650 patients with neuroendocrine neoplasms of the larynx have been reported in the literature (9). The most frequent type is the AC tumor, followed by SmCC, paraganglioma and finally, the TC tumor (10).…”

Section: Discussionmentioning

confidence: 99%

Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature

et al. 2015

View full text Add to dashboard Cite

Abstract. The aim of the present study was to review all cases of neuroendocrine tumors of the ear, nose and throat in a tertiary care center, as well as the data published in the literature. The study presents all the cases of neuroendocrine tumors (NETs) in the Hotel Dieu De France Hospital (Beirut, Lebanon) between January 2004 and January 2014. The data reported in the English and French literature is also reviewed with regard to the typical clinical presentation and management of these tumors. Three cases of NETs presented to the Department of Otolaryngology-Head and Neck Surgery during the study period. One case was of an atypical carcinoid (AC) tumor of the larynx, one case was of a typical carcinoid tumor in the middle ear and the third case was, to the best of our knowledge, the first reported case of an AC tumor of the nasopharynx. Overall, NETs are rare in the head and neck. The clinical presentation can mimic any other tumor in the same localization in the absence of a carcinoid syndrome. Management of these tumors remains controversial, but a complete excision of the tumor is crucial, followed by possible adjuvant treatment.

show abstract

Neuroendocrine neoplasms of the larynx: Advances in identification, understanding, and management

Cited by 96 publications

References 258 publications

Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series

Middle ear glandular neoplasms: adenoma, carcinoma or adenoma with neuroendocrine differentiation: a case series

Primary Neuroendocrine Carcinoma Combined with Squamous Cell Carcinoma of the Soft Palate: A Case Report and Review of Literature

Primary neuroendocrine tumors of the ear, nose and throat: A report of three cases and a review of the literature

Contact Info

Product

Resources

About