Neuroendocrine neoplasms of the extrahepatic bile duct: radiologic and clinical characteristics

Hong, Nurhee; Kim, Hyoung Jung; Byun, Jae Ho; Kim, So Yeon; Kim, Kyung Won; Kim, Jin Hee; Hong, Seung‐Mo

doi:10.1007/s00261-014-0191-0

Cited by 22 publications

(25 citation statements)

References 28 publications

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“…1,2,7 They account of 0.1 to 0.67% of all carcinoid tumors occurring most commonly in the CBD (Tables 1 and 2). 2,9 Like all NET, their behavior depends on their grading and their symptoms are caused by the tumor spread and growth. [10][11][12] Metastases occur mostly in the LN (43%) and the liver (32-73%) with a median survival around 2.2 years and a patient 5-year overall survival of 43%.…”

Section: Discussionmentioning

confidence: 99%

“…However, when poorly differentiated cells (Grade 3) are found, they are identified as neuroendocrine carcinomas (NEC). 6,8,9 Specific data about extra pancreatic non GIT (ectopic pancreas) NET treatment is not available. But, surgery remains the only therapeutic option being a part of a multidisciplinary approach.…”

Section: Introductionmentioning

confidence: 99%

“…28 It is considered the first line test with some limitations like missing small tumors (less than 1 cm of size) in 50% of cases and the lack of providing the exact tumor location unless associated to a CT Scan. 9,24 However, Somatostatin receptor scintigraphy may be helpful in assessing the levels of somatostatin-receptor expression for therapy. 29 Gallium-68-DOTA-NOC (PET)/CT (octreoscan) has a sensitivity of 90 % and a specificity of 80% for metastases detection.…”

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confidence: 99%

“…Finally, CT-scan of EHNET demonstrated a higher density when compared to the liver parenchyma on arterial phase. 9 Some authorities have discussed the eventual role of gallstones in the pathogenesis of EHNET. However, in one review only 3 out of 50 patients with EHNET have had a history of gallstones disease.…”

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confidence: 99%

“…38 Some cases have been seen in the setting of choledochal cyst. 9,15 One case was associated with a Hodgkin Lymphoma of the duodenum and another case was described in the setting of Von Hippel Lindau syndrome. 18,20 Like all NET, surgery is the best treatment option and different strategies have been adopted according to the tumor location.…”

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confidence: 99%

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Non-functioning neuroendocrine tumors of the common hepatic duct: a case report and literature review

Abou-Jaoudé

Nasser

2017

Int Surg J

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Extra-hepatic biliary tree neuroendocrine tumors are not common, accounting for about 0.1 % of all carcinoid tumors. Those affecting the common hepatic duct are very rare and their diagnosis is usually made post-operatively. Poorly differentiated tumors or neuroendocrine carcinomas are commonly seen in elderly, whereas well differentiated tumors, tend to occur in young patients, for whom surgery will lead to good long term results. About 100 cases have been reported in the English medical literature, showing good long term results after surgery for well differentiated (Grades 1 and 2) tumors. Herein, we report a case of an 18-year-old female, complaining from a dull epigastric pain related to a nodule compressing the common hepatic duct. After complete investigation, a laparotomy has been performed and showed a nodular tumor located in the common hepatic duct just above the insertion of the cystic duct with close contact with the pancreatic head distally. En bloc cholecystectomy with bile duct resection was performed and followed by a Roux-en-Y hepatico-jejunostomy. The pathology of the nodule came back to be a neuroendocrine tumor grade 2.

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