Neuroendocrine microRNAs linked to energy homeostasis: future therapeutic potential

Mak, Kimberly W. Y.; Mustafa, Aws; Belsham, Denise D.

doi:10.1007/s43440-022-00409-5

Cited by 2 publications

(1 citation statement)

References 181 publications

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“…There is abundant data in the literature on miRNAs involved in resistance to hormonal action, obesity, and related pathologies, such as some cancers and lipodystrophy [ 79 ], showing a close relationship with the regulation of energy homeostasis [ 80 ]. Some miRNAs play a role in obesity and adipogenesis, including let-7, miR-15a, miR-17-92, miR-21, miR-27, miR-30, miR-31, miR-103, miR-107, miR-125b, miR-130, miR-138, miR-143, miR-150, miR-200, miR204/211, miR-210, miR-221, miR-222, miR-326, miR-335, miR-355, miR-378,miR-448, and miR-519d, amongst others [ 81 ].…”

Section: Regulation Of Leptin Efficiencymentioning

confidence: 99%

Recent Advances in the Knowledge of the Mechanisms of Leptin Physiology and Actions in Neurological and Metabolic Pathologies

Casado

Collado-Pérez

Frago

et al. 2023

IJMS

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Excess body weight is frequently associated with low-grade inflammation. Evidence indicates a relationship between obesity and cancer, as well as with other diseases, such as diabetes and non-alcoholic fatty liver disease, in which inflammation and the actions of various adipokines play a role in the pathological mechanisms involved in these disorders. Leptin is mainly produced by adipose tissue in proportion to fat stores, but it is also synthesized in other organs, where leptin receptors are expressed. This hormone performs numerous actions in the brain, mainly related to the control of energy homeostasis. It is also involved in neurogenesis and neuroprotection, and central leptin resistance is related to some neurological disorders, e.g., Parkinson’s and Alzheimer’s diseases. In peripheral tissues, leptin is implicated in the regulation of metabolism, as well as of bone density and muscle mass. All these actions can be affected by changes in leptin levels and the mechanisms associated with resistance to this hormone. This review will present recent advances in the molecular mechanisms of leptin action and their underlying roles in pathological situations, which may be of interest for revealing new approaches for the treatment of diseases where the actions of this adipokine might be compromised.

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Section: Regulation Of Leptin Efficiencymentioning

confidence: 99%