Neuroendocrine Mechanisms of Social Bonds and Separation Stress in Rodents, Dogs, and Other Species

Nagasawa, Miho; Kikusui, Takefumi

doi:10.1007/7854_2021_257

Cited by 3 publications

(2 citation statements)

References 110 publications

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“…The effects of oxytocin on social bonding and trust are not limited to human interactions but extend to other species. Oxytocin has been shown to play a crucial role in maternal bonding in mammals, promoting the maternal-infant bond and facilitating nurturing behaviours [52][53][54]. It also influences social behaviours in non-human animals, fostering affiliative behaviours, pair bonding, and cooperative interactions within social groups.…”

Section: Oxytocin and Its Physiological Functions Particularly Its Ro...mentioning

confidence: 99%

The Love Hormone and Seizure Control: A Review of Oxytocin’s Impact on Epilepsy Management

Makhado,

Gertie Makhado

2024

Oxytocin and Social Function

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Epilepsy is a neurological disorder characterised by recurrent seizures, which can significantly impact patient’s quality of life. While current management strategies for epilepsy, such as antiepileptic drugs and surgery, are effective for many patients, there is a need for novel therapies that can provide better seizure control and improve patients’ outcomes. Oxytocin, a neuropeptide known for its role in social bonding and trust, has emerged as a promising therapy for epilepsy. Preclinical studies have shown that oxytocin can reduce seizure activity and improve seizure outcomes in animal models of epilepsy. In contrast, clinical studies have suggested that oxytocin may reduce seizure frequency and severity in some epilepsy patients. This chapter reviews the current knowledge of oxytocin and epilepsy, including the potential mechanisms of oxytocin’s antiepileptic effects, the limitations and challenges of clinical studies, and future research directions and implications. The chapter also discusses the broader impact of oxytocin research on understanding social behaviour and neurological disorders. Overall, the chapter highlights the potential of oxytocin as a novel therapy for epilepsy management and underscores the need for further research.

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Section: Oxytocin and Its Physiological Functions Particularly Its Ro...mentioning

confidence: 99%

The Love Hormone and Seizure Control: A Review of Oxytocin’s Impact on Epilepsy Management

Makhado,

Gertie Makhado

2024

Oxytocin and Social Function

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“…Prairie voles typically form lifelong, socially monogamous relationships with a single mate, exhibit biparental rearing of pups, and engage in alloparental care (McGraw and Young, 2010 ; Sadino and Donaldson, 2018 ; Walum and Young, 2018 ). The neural mechanisms responsible for these behaviors are modulated by neuropeptides, including oxytocin, vasopressin, and dopamine (Nair and Young, 2006 ; Young et al, 2008 ; Bosch and Young, 2017 ; Walum and Young, 2018 ), which are important for social bonding and communication in many species (Albers, 2012 ; Oettl et al, 2016 ; Marlin and Froemke, 2017 ; Froemke and Young, 2021 ; Nagasawa and Kikusui, 2021 ), including humans. In fact, studies using prairie voles and other vole species have been vital in furthering our understanding of the neural basis of affiliative behaviors.…”

Section: Introductionmentioning

confidence: 99%

Maturation of Social-Vocal Communication in Prairie Vole (Microtus ochrogaster) Pups

Warren

Campbell

Borie

et al. 2022

Front. Behav. Neurosci.

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Impairments in social communication are common among neurodevelopmental disorders. While traditional animal models have advanced our understanding of the physiological and pathological development of social behavior, they do not recapitulate some aspects where social communication is essential, such as biparental care and the ability to form long-lasting social bonds. Prairie voles (Microtus ochrogaster) have emerged as a valuable rodent model in social neuroscience because they naturally display these behaviors. Nonetheless, the role of vocalizations in prairie vole social communication remains unclear. Here, we studied the ontogeny [from postnatal days (P) 8–16] of prairie vole pup ultrasonic vocalizations (USVs), both when isolated and when the mother was present but physically unattainable. In contrast to other similarly sized rodents such as mice, prairie vole pups of all ages produced isolation USVs with a relatively low fundamental frequency between 22 and 50 kHz, often with strong harmonic structure. Males consistently emitted vocalizations with a lower frequency than females. With age, pups vocalized less, and the acoustic features of vocalizations (e.g., duration and bandwidth) became more stereotyped. Manipulating an isolated pup's social environment by introducing its mother significantly increased vocal production at older (P12–16) but not younger ages, when pups were likely unable to hear or see her. Our data provide the first indication of a maturation in social context-dependent vocal emission, which may facilitate more active acoustic communication. These results help lay a foundation for the use of prairie voles as a model organism to probe the role of early life experience in the development of social-vocal communication.

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Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles

et al. 2022

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Neuroendocrine Mechanisms of Social Bonds and Separation Stress in Rodents, Dogs, and Other Species

Cited by 3 publications

References 110 publications

The Love Hormone and Seizure Control: A Review of Oxytocin’s Impact on Epilepsy Management

The Love Hormone and Seizure Control: A Review of Oxytocin’s Impact on Epilepsy Management

Maturation of Social-Vocal Communication in Prairie Vole (Microtus ochrogaster) Pups

Social experience alters oxytocinergic modulation in the nucleus accumbens of female prairie voles

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