Neuroendocrine mechanisms of change in food intake during pregnancy: A potential role for brain oxytocin

Douglas, Alison J.; Johnstone, Louise E.; Leng, Gareth

doi:10.1016/j.physbeh.2007.04.012

Cited by 96 publications

(68 citation statements)

References 125 publications

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“…Magnocellular oxytocin neurons are activated by feeding, and i.c.v. administration of oxytocin antagonist increases food intake [12], indicating a possible role of oxytocin in the regulation of feeding behavior. These data raised a possibility that oxytocin may be involved in the nesfatin-1-induced anorexia in the hypothalamus.…”

Section: Peripheral Nesfatin/nucb2 Expressionmentioning

confidence: 97%

“…Nesfatin-1 neurons in the PVN and SON co-expressed oxytocin and vasopressin [10]. double-labeling immunohistochemistry revealed co-localization of nesfatin/ NuCB2 with vasopressin and oxytocin in magnocellular neuroendocrine neurons, thyrotropin-releasing hormone (TrH), corticotropin-releasing hormone (CrH), somatostatin, neurotensin, and growth hormone-releasing hormone (GrH) in parvocellular neuroendorine neurons of the PVN [12]. Magnocellular oxytocin neurons are activated by feeding, and i.c.v.…”

Section: Peripheral Nesfatin/nucb2 Expressionmentioning

confidence: 99%

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Nesfatin-1: An Overview and Future Clinical Application

et al. 2009

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Abstract. Nesfatin/nucleobindin 2 (NuCB2) is expressed in the appetite-control hypothalamic nuclei and brainstem nuclei. Nesfatin/NuCB2 expression in the paraventricular nucleus of the hypothalamus was modulated by starvation and refeeding. intracerebroventricular administration of nesfatin-1 dose-dependently inhibited food intake for 6 hours in male Wistar and leptin resistant, zucker fatty rats. intraperitoneal administration of nesfatin-1 and its mid-segment (m30) dosedependently inhibited food intake for 3 hours in male iCr mice. intraperitoneal administration of m30 also decreased food intake in leptin-resistant, genetically obese (ob/ob), diabetic (db/db) mice and mice fed a 45% high fat diet for 28 days. intraperitoneal administration of m30 increased proopiomelanocortin and cocaine-and amphetamine-related peptide mRNA expression in the nucleus of the solitary tract of mice. In addition, intranasal administration of nesfatin-1 significantly inhibited food intake for 6 hours in male Wistar rats. We summarize recent observations about nesfatin-1, and attempt to present future direction of nesfatin-1 research for developing a new anti-obesity treatment.Key words: Nesfatin-1, Leptin, Food intake, Body weight, Obesity (Endocrine Journal 56: [537][538][539][540][541][542][543] 2009) We have proposed the concept of brain-adipose axis that endogenous molecule, expressed in both hypothalamus and adipose tissue, exists in the general circulation, and is involved in the regulation of both feeding behavior, and the determination of size and/ or number of adipocytes [1]. Troglitazone, peroxisome proliferator-activated receptor-γ (PPARγ) agonist, might modify the satiety in type 2 diabetic patients [2], and we attempted to identify a new protein regulated by PPARγ, which modulates feeding behavior. By using a subtraction-cloning assay, we found a new anorexigenic protein increased by troglitazone, and named it NEFa/nucleobindin 2 encoded satietyand fat-influencing protein (nesfatin), corresponding to NEFa/nucleobindin 2 (NuCB2), which had been reported to be a secreted protein of unknown function [3]. Nesfatin/NuCB2 is composed of a signal peptide of 24 amino acids and a protein structure containing 396 amino acids (Fig. 1). The homology of the amino acid sequence of nesfatin/NuCB2 is highly conserved in humans, mice and rats. in this review, we summarize recent observation about the physiological role of nesfatin-1, and discuss future direction for the research of this anorexigenic protein. Anorexigenic effect of nesfatin and its fragmentsNesfatin/NuCB2 is expressed in the appetite-control hypothalamic nuclei such as paraventricular nucleus (PVN), arcuate nucleus (ARC), supraoptic nucleus (SON) of hypothalamus, lateral hypothalamic area (LHa), and zona incerta in rats [3]. Nesfatin-1-immunoreactivity was also found in the brainstem nuclei such as nucleus of the solitary tract (NTS) and dorsal nucleus of vagus [3,4]. Selective reduction of nesfatin/NUCB2 mRNA expression in the PVN of rat was found under starved cond...

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Section: Peripheral Nesfatin/nucb2 Expressionmentioning

confidence: 97%

Section: Peripheral Nesfatin/nucb2 Expressionmentioning

confidence: 99%

Nesfatin-1: An Overview and Future Clinical Application

et al. 2009

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“…In addition to this growth of somatic tissue, many species also deposit fat stores during pregnancy, which can be drawn from later in lactation. Rats (Rattus norvegicus), for example, increase adiposity in the last week of pregnancy (Asarian and Geary, 2006;Douglas et al, 2007;Gray and Wade, 1981;Shirley, 1984) and pregnant dairy cattle (Bos taurus) increase stored fat during early gestation before the development of the mammary glands starts (Uvnäs- Moberg, 1989). In this way the pregnant female may programme her performance to match anticipated demands in lactation (but see Duah et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Limits to sustained energy intake. XVI. Body temperature and physical activity of female mice during pregnancy

Gamo

Bernard

Mitchell

et al. 2013

Journal of Experimental Biology

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SUMMARYLactation is the most energy-demanding phase of mammalian reproduction, and lactation performance may be affected by events during pregnancy. For example, food intake may be limited in late pregnancy by competition for space in the abdomen between the alimentary tract and fetuses. Hence, females may need to compensate their energy budgets during pregnancy by reducing activity and lowering body temperature. We explored the relationships between energy intake, body mass, body temperature and physical activity throughout pregnancy in the MF1 mouse. Food intake and body mass of 26 females were recorded daily throughout pregnancy. Body temperature and physical activity were monitored every minute for 23h a day by implanted transmitters. Body temperature and physical activity declined as pregnancy advanced, while energy intake and body mass increased. Compared with a pre-mating baseline period, mice increased energy intake by 56% in late pregnancy. Although body temperature declined as pregnancy progressed, this served mostly to reverse an increase between baseline and early pregnancy. Reduced physical activity may compensate the energy budget of pregnant mice but body temperature changes do not. Over the last 3days of pregnancy, food intake declined. Individual variation in energy intake in the last phase of pregnancy was positively related to litter size at birth. As there was no association between the increase in body mass and the decline in intake, we suggest the decline was not caused by competition for abdominal space. These data suggest overall reproductive performance is probably not constrained by events during pregnancy. Supplementary material available online at

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“…It is now known that immunopositive reaction to NUCB2/nesfatin-1 also occurs in other areas, including the periventricular nucleus, Edinger-Westphal nucleus, dorsal nucleus of the vagus nerve, insular cortex, cerebellum as well as sympathetic and parasympathetic neurons of the spinal cord within the thoracic, lumbar, and sacral parts (6,14,16,20,24,31,38,62). Within neurons, nesfatin-1 occurs in conjunction with different neurotransmitters, including primarily melanin (MEL), cocaine-and amphetamine-regulated transcript (CART), proopiomelanocortin (POMC), α-melanocyte-stimulating hormone (α-MSH), growth hormone-releasing hormone (GHRH), thyrotropin-releasing hormone (TRH), corticotropin-releasing hormone (CRH), oxytocin (OT), vasopressin (AVP), neurotensin (NT), acetylocholine (Ach), and serotonin (SER) (6,12,14,16,31,34,39). The anatomical location of neurons expressing nesfatin-1 and its coexistence with neurotransmitters suggests that the physiological role of nesfatin-1 is not limited to the regulation of food intake, but also includes the regulation of neuroendocrine and autonomic control of internal organs and emotional reactions (14,22,34).…”

Section: Artykuł Przeglądowy Reviewmentioning

confidence: 99%

Role of nesfatin-1 in the metabolism of skeletal tissues

Puzio¹,

Tymicki²,

Predka³

et al. 2018

Medycyna Weterynaryjna

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Puzio I., Tymicki G., Predka H., Śleboda W., Sobczyńska-Wołejszo M.Role of nesfatin-1 in the metabolism of skeletal tissues Summary NUCB2/nesfatin-1, a member of the adipokine family, is a peptide hormone with pleiotropic action. It has been found in different tissues, including cartilage and bone cells. Nesfatin-1 is produced by chondrocytes, and its synthesis increases with the degree of cell differentiation and upon stimulation by pro-inflammatory cytokines, as shown in an in vitro study. An increase in serum levels of nesfatin-1 has been observed in humans with osteoarthritis, which indicates the influence of pro-inflammatory cytokines on nesfatin-1 release. On the other hand, nesfatin-1 stimulates the synthesis of pro-inflammatory cytokines by chondrocytes, which suggests its participation, together with other adipokines, in the pathogenesis and/or progression of inflammatory complications of cartilage degenerative diseases. Nesfatin-1 also promotes pre-osteoblastic cell differentiation and mineralization and inhibits macrophage differentiation towards osteoclasts. Moreover, exogenous nesfatin-1 given to ovariectomized rats reduces osteopenic changes. Therefore, it seems that nesfatin-1 may play a protective role in cartilage and bone diseases. However, further studies are required to determine whether nesfatin-1 can be used for monitoring and treatment of cartilage and bone diseases.

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Neuroendocrine mechanisms of change in food intake during pregnancy: A potential role for brain oxytocin

Cited by 96 publications

References 125 publications

Nesfatin-1: An Overview and Future Clinical Application

Nesfatin-1: An Overview and Future Clinical Application

Limits to sustained energy intake. XVI. Body temperature and physical activity of female mice during pregnancy

Role of nesfatin-1 in the metabolism of skeletal tissues

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