Abstract:Many clinical and preclinical studies report higher prevalence and severity of chronic pain in females. We used hyperalgesic priming with interleukin 6 (IL-6) priming and PGE2 as a second stimulus as a model for pain chronicity. Intraplantar IL-6 induced hypersensitivity was similar in magnitude and duration in both males and females, while both paw and intrathecal PGE2 hypersensitivity was more persistent in females. This difference in PGE2 response was dependent on both circulating estrogen and translation r… Show more
“…What is the role of innate and adaptive immune signaling in the chronification? ( 15 ) What role does the sex of the subject play ( 16 ). Based on the above answers, one might speculate that therapeutics regulating early and late pain may not be the same as the pharmacology of the therapeutic which targets the transition ( 17 , 18 ).…”
Section: Therapeutics In the Acute And Chronic Pain Transitionmentioning
“…What is the role of innate and adaptive immune signaling in the chronification? ( 15 ) What role does the sex of the subject play ( 16 ). Based on the above answers, one might speculate that therapeutics regulating early and late pain may not be the same as the pharmacology of the therapeutic which targets the transition ( 17 , 18 ).…”
Section: Therapeutics In the Acute And Chronic Pain Transitionmentioning
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