Neuroendocrine liver metastases: Value of apparent diffusion coefficient and enhancement ratios for characterization of histopathologic grade

Besa, Cecilia; Ward, Stephen; Cui, Yong; Jajamovich, Guido H.; Kim, Michelle; Taouli, Bachir

doi:10.1002/jmri.25320

Cited by 22 publications

(13 citation statements)

References 39 publications

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“…The use of dynamic enhanced CT has been described as being helpful in differentiating tumor pathologic grade in GEP-NENs. Some studies of pancreatic NENs have shown that well-differentiated tumors are more vascularized than poorly-differentiated tumors on enhanced CT (16)(17)(18). In our study, a higher degree of enhancement was found in LMs of well-differentiated GEP-NENs both in the hepatic arterial and portal venous phases compared to poorly-differentiated GEP-NENs.…”

Section: Discussionsupporting

confidence: 58%

Utility of CT in differentiating liver metastases of well-differentiated gastroenteropancreatic neuroendocrine neoplasms from poorly-differentiated neuroendocrine neoplasms

Cui

Gao

et al. 2018

Chinese Journal of Cancer Research

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Section: Discussionsupporting

confidence: 58%

Utility of CT in differentiating liver metastases of well-differentiated gastroenteropancreatic neuroendocrine neoplasms from poorly-differentiated neuroendocrine neoplasms

Cui

Gao

et al. 2018

Chinese Journal of Cancer Research

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“…Several studies have shown that DWI is more sensitive for the detection of liver metastases than T2-weighted and multiphase gadolinium-enhanced MRI, especially for smaller lesions[ 72 - 74 ]. Besa et al [ 75 ] showed that the ADC of liver metastases from NEN weakly and significantly correlated negatively with tumor grade and Ki-67 and that the mean ADC and the minimum ADC values were significantly different between the three grades (1.6, 1.35 and 0.9 × 10 3 mm 2 /s and 0.84, 0.5 and 0.27 × 10 3 mm 2 /s for grades 1, 2 and 3, respectively). DWI is hence recommended in routine MRI abdomen protocol for the detection of liver metastases from NEN.…”

Section: Mrimentioning

confidence: 99%

Advances in the imaging of gastroenteropancreatic neuroendocrine neoplasms

Ramachandran¹,

Madhusudhan²

2022

WJG

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Gastroenteropancreatic neuroendocrine neoplasms comprise a heterogeneous group of tumors that differ in their pathogenesis, hormonal syndromes produced, biological behavior and consequently, in their requirement for and/or response to specific chemotherapeutic agents and molecular targeted therapies. Various imaging techniques are available for functional and morphological evaluation of these neoplasms and the selection of investigations performed in each patient should be customized to the clinical question. Also, with the increased availability of cross sectional imaging, these neoplasms are increasingly being detected incidentally in routine radiology practice. This article is a review of the various imaging modalities currently used in the evaluation of neuroendocrine neoplasms, along with a discussion of the role of advanced imaging techniques and a glimpse into the newer imaging horizons, mostly in the research stage.

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“…Generally, hyper-enhancement has been considered as the common character of NETs [ 12 , 13 ]. The liver metastases of NETs tended to present similar enhancement features with their primary lesions [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Dynamic enhanced CT: is there a difference between liver metastases of gastroenteropancreatic neuroendocrine tumor and adenocarcinoma

Cui

et al. 2017

Oncotarget

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This study proposed to evaluate the feasibility of dynamic enhanced CT in differentiation of liver metastases of gastroenteropancreatic well-differentiated neuroendocrine tumors (GEP NETs) from GEP adenocarcinomas based on their characteristic features. CT images of 23 well-differentiated (G1 or G2) GEP NETs and 23 GEP adenocarcinomas patients with liver metastases were retrospectively reviewed. The distribution type, shape, intra-tumoral neovascularity, enhancement on hepatic artery phase, dynamic enhancement pattern and lymphadenopathy were subjective analyzed. Meanwhile, the size, number, CT value of tumor and adjacent normal liver parenchyma were measured and the metastasis-to-liver ratios were calculated objectively. Compared with GEP adenocarcinomas, the liver metastases of GEP NETs more frequently demonstrated a hyper enhancement on hepatic artery phase, washout dynamic enhancement pattern, absence of lymphadenopathy and higher metastasis-to-liver ratios on both hepatic artery phase and portal venous phase (P=0.017, P<0.001, P =0.038, P <0.001 and P =0.008, respectively). Logistic regression analysis showed that the dynamic enhancement pattern (P=0.012), and the metastasis-to-liver ratios on hepatic artery phase (P=0.009) were independent CT predictors for liver metastases of GEP NETs. The sensitivity and specificity of combing the two predictors in differentiation of liver metastases of GEP adenocarcinomas from GEP NET were 82.6% (19 of 23) and 91.3% (21 of 23), respectively. CT features are helpful in differentiating liver metastases of well-differentiated GEP NETs from that of GEP adenocarcinomas.

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Neuroendocrine liver metastases: Value of apparent diffusion coefficient and enhancement ratios for characterization of histopathologic grade

Abstract: ADC is a promising marker for characterization of histopathologic grade of NETLM. These results should be confirmed in a prospective study. J. Magn. Reson. Imaging 2016;44:1432-1441.

Cited by 22 publications

References 39 publications

Utility of CT in differentiating liver metastases of well-differentiated gastroenteropancreatic neuroendocrine neoplasms from poorly-differentiated neuroendocrine neoplasms

Utility of CT in differentiating liver metastases of well-differentiated gastroenteropancreatic neuroendocrine neoplasms from poorly-differentiated neuroendocrine neoplasms

Advances in the imaging of gastroenteropancreatic neuroendocrine neoplasms

Dynamic enhanced CT: is there a difference between liver metastases of gastroenteropancreatic neuroendocrine tumor and adenocarcinoma

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