2000
DOI: 10.1002/1097-0142(20001201)89:11<2230::aid-cncr11>3.0.co;2-x
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Neuroendocrine-like differentiation in patients with pancreatic carcinoma

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Cited by 32 publications
(30 citation statements)
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“…6,7,26 In our study, the majority of tumors had focal NE differentiation (<5% of tumor cells). This finding was similar to previous studies, which found focal NE differentiation in tumors from multiple organ sites, including tumors of the pancreas, 13 colon, 21,22,25,27,28 and esophagus. 7,26 It is noteworthy that, in the current study, the percentage of tumor cells with NE differentiation was increased significantly in residual tumor in posttreatment resection specimens compared with paired tumor in pretreatment biopsy specimens.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…6,7,26 In our study, the majority of tumors had focal NE differentiation (<5% of tumor cells). This finding was similar to previous studies, which found focal NE differentiation in tumors from multiple organ sites, including tumors of the pancreas, 13 colon, 21,22,25,27,28 and esophagus. 7,26 It is noteworthy that, in the current study, the percentage of tumor cells with NE differentiation was increased significantly in residual tumor in posttreatment resection specimens compared with paired tumor in pretreatment biopsy specimens.…”
Section: Discussionsupporting
confidence: 92%
“…It has been reported that tumors with NE differentiation imply a good prognosis for patients pancreatic carcinomas, 13 a poor prognosis for patients with prostatic adenocarcinomas, 14,15 and have no effect on clinical outcome in patients with breast carcinomas. 16,17 The prognostic relevance of NE differentiation in colonic adenocarcinomas is controversial, [18][19][20][21][22][23][24] but most studies have observed that NE differentiation was associated with a worse prognosis in patients with colonic adenocarcinomas.…”
Section: Discussionmentioning
confidence: 99%
“…We can only speculate about this phenomenon. Tezel et al (2000) showed that pancreatic tumours with neuroendocrine-like differentiation showed a significantly better survival rate. In contrast to typical exocrine adenocarcinoma, neuroendocrine differentiation does not exhibit CA 19-9.…”
Section: Discussionmentioning
confidence: 99%
“…Mutations of the UCH-L1 gene have been associated with familial Parkinson's disease (Lansbury and Brice, 2002) and with other neurodegenerative disorders characterized by the formation of protein aggregates, including spinocerebellar ataxia (Fernandez-Funez et al, 2000) and Huntington's disease (Naze et al, 2002). In addition, high levels of UCH-L1 have been detected in a variety of human malignancies including neuroblastoma (Yanagisawa et al, 1998), colon carcinoma (Yamazaki et al, 2002), non-small-cell-lung carcinoma (Brichory et al, 2001;Sasaki et al, 2001), pancreatic carcinoma (Tezel et al, 2000), prostate and breast carcinomas (Schumacher et al, 1994;Aumuller et al, 1999) and renal carcinoma (D'Andrea et al, 1997), and appear to be associated with the more malignant and invasive forms of these tumors. The physiological targets of UCH-L1 are unknown.…”
Section: The Rescue Program: Lmp-2a and The Capture Of Cellular Ubiqumentioning
confidence: 99%