Neuroendocrine–Immune Regulatory Network of Eucommia ulmoides Oliver

Zhao, Yi; Tan, Darren Qiancheng; Peng, Bo; Yang, Lin; Zhang, Siyuan; Shi, Rui-Peng; Chong, Cheong-Meng; Zhong, Zhangfeng; Wang, Shengpeng; Liang, Qionglin; Wang, Yitao

doi:10.3390/molecules27123697

Cited by 9 publications

(5 citation statements)

References 155 publications

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“…With in-depth studies, some flavonoids, including quercetin and kaempferol, have also been identified in PN. A study based on animal experiments showed that combining PNS with other notoginseng flavones increased its biological activity (42). This work provided valuable experimental evidence and clues for the design of anti-fatiguing compounds.…”

Section: Discussionmentioning

confidence: 79%

“…Among these products, EUOB has the highest frequency and is often used as the main component of related products. Traditionally, EUOB is thought to be a major medicinal component for prevention and treatment of chronic diseases such as osteoporosis, arthritis, and hypertension (41)(42)(43). However, slow growth of trunk bark has limited the supply of EUOB.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, peeling off too much bark is likely to lead to the death of EUO trees. To ensure optimal use of EUO resources, studies have aimed at establishing the significance of other medicinal parts of EUO (42,44). Even though EUOF and EUOB have comparable compositions, there are some differences in contents of active ingredients between them.…”

Section: Introductionmentioning

confidence: 99%

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Feasibility study on the use of “Qi-tonifying medicine compound” as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking

Cao

et al. 2023

Front. Nutr.

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IntroductionFatigue has attracted broad attention in recent years due to its high morbidity rates. The use of functional foods to relieve fatigue-associated symptoms is becoming increasingly popular and has achieved relatively good results. In this study, network pharmacology and molecular docking strategies were used to establish the material basis and mechanisms of Chinese herbal compounds in fatigue treatment. According to traditional medicine theories and relevant guidance documents published by the Chinese Ministry of Health, four herbal medicines, including Eucommia ulmoides Oliver bark, Eucommia ulmoides Oliver male flower, Panax notoginseng, and Syzygium aromaticum (EEPS), were selected to constitute the anti-fatigue herbal compound that may be suitable as functional food ingredients.MethodsThe major active ingredients in EEPS were identified via comprehensive literature search and Traditional Chinese Medicine Systems Pharmacology database search. Corresponding targets for these ingredients were predicted using SwissTargetPrediction. The network was constructed using Cytoscape 3.9.1 to obtain key ingredients. Prediction of absorption, distribution, metabolism, excretion and toxicity properties was performed using the ADMETIab 2.0 database. The anti-fatigue targets were retrieved from GeneCards v5.13, OMIM, TTD and DisGeNET 7.0 databases. Then, the potential targets of EEPS in fatigue treatment were screened through a Venn diagram. A protein–protein interaction (PPI) network of these overlapping targets was constructed, and the hub targets in the network selected through topological screening. Gene Ontology and KEGG pathway enrichment analyses were performed using the DAVID database and the bioinformatics online platform. Finally, AutoDock tools were used to verify the binding capacity between the key active ingredients and the core targets.Results and DiscussionThis study identified the active ingredients and potential molecular mechanisms of EEPS in fatigue treatment, which will provide a foundation for future research on applications of herbal medicines in the functional food industry.

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Section: Discussionmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Feasibility study on the use of “Qi-tonifying medicine compound” as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking

Cao

et al. 2023

Front. Nutr.

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“…Eucommia ulmoides Oliver (EU), also known as Du-Zhong in China and Tuchong in Japan, is a traditional medicinal plant that originated in China and is widely distributed in central and southwest China, including Henan, Hunan, Jiangxi, and Shanxi provinces [ 1 ]. The bark of E. ulmoides (EUB) has been used in traditional Chinese medicine for more than 2000 years.…”

Section: Introductionmentioning

confidence: 99%

Quality Marker Discovery and Quality Evaluation of Eucommia ulmoides Pollen Using UPLC-QTOF-MS Combined with a DPPH-HPLC Antioxidant Activity Screening Method

Guo

Yang

et al. 2023

Molecules

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Pollen, as an important component of Eucommia ulmoides (EUP), is rich in nutrients and is receiving increasing attention. At present, there are no reports on research related to the chemical composition and quality standards of EUP, and there are significant quality differences and counterfeit phenomena in the market. This study used a UPLC-QTOF-MS system to identify 49 chemical components in EUP for the first time. In the second step, 2,2-diphenyl-1-picrylhydrazyl (DPPH)-HPLC antioxidant activity screening technology was used to identify the main active components of EUP, quercetin-3-O-sophoroside (QSH), quercetin-3-O-sambubioside (QSB), and quercetin 3-O-neohesperidoside (QNH), and their purification, preparation, and structure identification were carried out. Third, molecular docking was used to predict the activity of these components. Fourth, the intracellular ROS generation model of RAW264.7 induced by H2O2 was used to verify and evaluate the activity of candidate active ingredients to determine their feasibility as Q-markers. Finally, a quality control method for EUP was constructed using the three selected components as Q-markers. The identification of chemical components and the discovery, prediction, and confirmation of characteristic Q-markers in EUP provide important references for better research on EUP and the effective evaluation and control of its quality. This approach provides a new model for the quality control of novel foods or dietary supplements.

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“…Fitting drugs that promote callus growth while fixing broken bones is a common means of treating fractures in the clinic [5] . In traditional medicine, many Chinese herbs promote bone fracture healing, such as osteoclast supplementation, Eucommia ulmoides, and sequestration [6,7] . It is also commonly used in the clinic to treat fractures by prescription-containing osteoclast supplementation.…”

mentioning

confidence: 99%

Network-Based Pharmacology to Explore the Role of Drynaria fortune in Combination with Platelet-Rich Plasma Intervention for Fracture Healing Disorders

Rong,

Liu,

Yang

et al. 2024

IJPS

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Rong et al.: To Explore the Role of Drynaria fortunei with Platelet-Rich Plasma InterventionBased on network pharmacology and molecular docking techniques and methods, to explore the active components and potential effects of Drynaria fortunei combined with platelet-rich plasma intervention therapy on fracture healing diseases. The gene cards database, the human Mendelian genetic database, Online Mendelian Inheritance in Man database, and the DisGeNET database were searched to identify fracture-related targets. Then, the active chemical components and targets in Rhizoma Drynariae were screened through the traditional Chinese medicine systematic pharmacology and analysis platform database. Then, the characteristic genes of platelet-rich plasma were searched through the GSE203196, and the common targets of drugs and diseases were screened through R language. Construct a drug candidate compound target network diagram. Use the protein interaction network function enrichment analysis database and the Cytoscape software to build a protein interaction network, use AutoDock Vina for analysis and docking, use R language to conduct Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis on the critical targets of the fracture of the combination of Drynaria fortunei and platelet-rich plasma intervention therapy, and determine the core target and mechanism of the variety of Drynaria fortunei and platelet-rich plasma treatment of the fracture. A total of 18 active compounds were obtained from Rhizoma Drynariae. There are 18 overlapping targets of Drynaria and platelet-rich plasma fracture. There are 13 active ingredients related to disease targets. Rhizoma Drynariae and plateletrich plasma are mainly involved in regulating prostaglandin-endoperoxide synthase 2, androgen receptor, caspase-2, and B-cell lymphoma 2 to play a role in treating fractures. The treatment of fracture with Drynaria fortunei combined with platelet-rich plasma is a complex process of multicomponents, multi-targets, and multi-pathways related to the coordinated regulation of multiple targets and signal pathways.

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Neuroendocrine–Immune Regulatory Network of Eucommia ulmoides Oliver

Cited by 9 publications

References 155 publications

Feasibility study on the use of “Qi-tonifying medicine compound” as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking

Feasibility study on the use of “Qi-tonifying medicine compound” as an anti-fatigue functional food ingredient based on network pharmacology and molecular docking

Quality Marker Discovery and Quality Evaluation of Eucommia ulmoides Pollen Using UPLC-QTOF-MS Combined with a DPPH-HPLC Antioxidant Activity Screening Method

Network-Based Pharmacology to Explore the Role of Drynaria fortune in Combination with Platelet-Rich Plasma Intervention for Fracture Healing Disorders

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