Neuroendocrine-immune regulating mechanisms for the anti-inflammatory and analgesic actions of acupuncture

Xu, Zhifang; Hong, Shouhai; Wang, Shenjun; Zhao, Xue; Liu, Yangyang; Ding, Shan; Xu, Yueyue; Zhang, Kuo; Yu, Nan‐Nan; Lu, Zhong-Xi; Fu, Yang; Gong, Yi-Nan; He, Qinqin; Yu, Kun; Zhang, Yiping; Dou, Baomin; Yao, Lin; Yan, Ya-Wen; Yang, Tao; Zhang, Yanfang; Liu, Baohu; Guo, Yongming; Wong, Hsuah-Nee-Connie; Guo, Yi

doi:10.4103/wjtcm.wjtcm_41_20

Cited by 16 publications

(7 citation statements)

References 40 publications

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“…The VAS score can be used as a quantitative reference for the painful condition of lumbar spondylosis [ 14 ]. The ODI can be used as a quantitative indicator of low back pain dysfunction and is important in reflecting functional recovery [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Outcome of Percutaneous Transforaminal Endoscopic Lumbar Decompression for Multisegment Lumbar Spinal Stenosis and the Effect on VAS Scores

Guo

2022

Evidence-Based Complementary and Alternative Medicine

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Purpose. To investigate the efficacy of percutaneous transforaminal endoscopic lumbar decompression (PTED) in the treatment of multisegment lumbar spinal stenosis (LSS) and its effect on VAS scores. Methods. 126 patients with multisegment LSS admitted between August 2017 and August 2021 were selected and divided into the PTED group and the traditional open surgery group (TOS group) according to the different treatment methods. There were 70 cases in the PTED group, treated with PTED, and 56 cases in the TOS group, treated with traditional open surgery. The clinical outcomes, the preoperative and postoperative pain visual analogue scale (VAS), the Oswestry disability index (ODI), the SF-36 quality of life questionnaire scores, the perioperative indicators (operative time, days in hospital, intraoperative blood loss), the postoperative complications, and imaging data were compared between the two groups. Results. After the operation, the excellent and good rate in the PTED group (91.43%) was significantly higher than that in the TOS group (75.00%) ( P < 0.05 ). At each time after the operation, the VAS and ODI scores of the two groups were lower than those before the operation, and the VAS scores of the PTED group at 1 day and 3 months after operation were lower than those of the TOS group, and the ODI scores of the PTED group at 3 months after operation were lower than those of the TOS group ( P < 0.05 ). 3 months after the operation, the SF-36 scores in both groups were higher than those before the operation, and those in the PTED group were higher than those in the TOS group ( P < 0.05 ). The operation time and days in hospital in the PTED group were shorter than those in the TOS group, and the intraoperative dominant blood loss and recessive blood loss were less than those in the TOS group ( P < 0.05 ). The total incidence of complications in the PTED group (15.71%) was significantly lower than that in the TOS group (32.14%) ( P < 0.05 ). Conclusion. Both PTED and traditional open surgery are effective in treating patients with multisegmental LSS, and both show positive postoperative changes in all indicators, but the former has more promising near -term results in improving lumbar spine pain, function and quality of life than the latter, and has the advantages of less trauma, less bleeding, and fewer complications.

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Section: Discussionmentioning

confidence: 99%

Outcome of Percutaneous Transforaminal Endoscopic Lumbar Decompression for Multisegment Lumbar Spinal Stenosis and the Effect on VAS Scores

Guo

2022

Evidence-Based Complementary and Alternative Medicine

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“…For example, after acupuncture, macrophages are transformed from the M1 pro-inflammatory type to the M2 anti-inflammatory type. 90 It can also inhibit the expression of pro-inflammatory cytokines (TNF-α, IL-1, IL-6, etc.) or promote the release of anti-inflammatory and tissue repair factors (IL-10 and TGF-β) to regulate body inflammation.…”

Section: Discussionmentioning

confidence: 99%

Research Hotspots and Trends on Acupuncture for Anti-Inflammation: A Bibliometric Analysis from 2011 to 2021

Chen¹,

Liu²,

Li³

et al. 2023

JPR

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Purpose We here explored the research status, research hotspots, and development trend of acupuncture against inflammation from both quantitative and qualitative aspects through bibliometrics. Methods We used CiteSpace and VOSviewer to analyze the literature about acupuncture against inflammation from 2011 to 2021 in the Web of Science Core Collection database by using a visual knowledge map. Results In total, 1479 articles were included, and the number of articles published each year exhibited an upward trend. The largest number of articles were published in China (661), followed by the United States (287) and South Korea (164). The most productive institution is Beijing University of Chinese Medicine (72), while the most influential institution is the Capital Medical University (0.28). Evidence-based Complementary and Alternative Medicine (131) is the journal that published most articles on the topic. Lin Yiwen is the most prolific author, and Borovikova L is the most influential co-cited author. The keywords that have burst in the last 2 years are inflammation and activation. The keywords with the highest frequency of use are electroacupuncture (EA), inflammation, and expression. Conclusion The number of publications on acupuncture for anti-inflammation research is rapidly increasing. China is a productive country, but the influence of centrality is poor. Research institutions are concentrated in universities, and the whole collaborative network needs to be strengthened. The anti-inflammatory mechanism of acupuncture is the main focus of research in this field. Regulation of immune cell balance by acupuncture may be a hot topic in mechanism research. At present, immune cells, vagus nerve, signal pathway, inflammatory corpuscles, cytokines and neurotransmitters are popular research topics. In the future, the basic research of acupuncture for anti-inflammation transformed into clinical practice may be a trend. EA and bee venom acupuncture may be promising research directions for acupuncture treatment for inflammatory diseases.

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“…Of note, the anti‐inflammatory action of acupuncture, especially in sepsis, has been much more interesting to researchers (Liu et al, 2020; Liu et al, 2021; Song et al, 2012; Xie et al, 2020). Although current progress revealed that acupuncture‐induced anti‐inflammatory effect is predominately achieved by activating the autonomic nervous anti‐inflammatory pathways (sympathetic‐ and vagal‐splenic pathway, vagal‐adrenal medulla‐dopamine pathway) in a body region‐dependent manner, rather than hypothalamic–pituitary–adrenal cortex axis (Ma, 2022; Pan et al, 2021; Torres‐Rosas et al, 2014; Xu et al, 2020), although the stimulation intensity and acupuncture points for driving the autonomic routes are still debatable.…”

Section: Introductionmentioning

confidence: 99%

Adrenal sympathetic nerve mediated the anti‐inflammatory effect of electroacupuncture at ST25 acupoint in a rat model of sepsis

Zhang

Cui

Liu

et al. 2022

The Anatomical Record

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Acupuncture plays a vital anti‐inflammatory action in sepsis by activating autonomic nerve anti‐inflammatory pathways, such as sympathoadrenal medullary pathway, but the mechanism remains unclear. This study aims to explore the optimum parameter of electroacupuncture (EA) stimulation in regulating the sympathoadrenal medullary pathway and evaluate EA's anti‐inflammatory effect on sepsis. To determine the optimum parameter of EA at homotopic acupoint on adrenal sympathetic activity, the left adrenal sympathetic nerve firing rate evoked by different intensities of single shock electrical stimulation (ES) at ST25 in healthy male Sprague–Dawley rats were evaluated by in vivo electrophysiological recording, and the levels of norepinephrine (NE) and its metabolites normetanephrine (NMN) were also examined using mass spectrometry. To verify the role of EA at ST25 in sepsis, the rats were given an intraperitoneal injection of lipopolysaccharide (LPS) to induce sepsis model, and survival rate, clinical score, and the level of interleukin (IL)‐6, IL‐1β, and IL‐10 were evaluated after EA application. We observed that 3 mA is the optimal intensity for activating adrenal sympathetic nerve, which significantly elevated the level of NE in the peripheral blood. For LPS‐treated rats, EA at the ST25 apparently increased the survival rate and improved the clinical score compared to the control group. Furthermore, 3 mA EA at ST25 significantly decreased pro‐inflammatory cytokines IL‐6 and IL‐1β and upregulated anti‐inflammatory cytokine IL‐10 compared to the LPS‐treated group. Overall, our data suggested that 3 mA is the optimal EA intensity at ST25 to activate the sympathoadrenal medullary pathway and exert an anti‐inflammatory effect in sepsis.

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Neuroendocrine-immune regulating mechanisms for the anti-inflammatory and analgesic actions of acupuncture

Cited by 16 publications

References 40 publications

Outcome of Percutaneous Transforaminal Endoscopic Lumbar Decompression for Multisegment Lumbar Spinal Stenosis and the Effect on VAS Scores

Outcome of Percutaneous Transforaminal Endoscopic Lumbar Decompression for Multisegment Lumbar Spinal Stenosis and the Effect on VAS Scores

Research Hotspots and Trends on Acupuncture for Anti-Inflammation: A Bibliometric Analysis from 2011 to 2021

Adrenal sympathetic nerve mediated the anti‐inflammatory effect of electroacupuncture at ST25 acupoint in a rat model of sepsis

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