Neuroendocrine-Immune Interactions and Starvation in Mucosal Immunity and Mucosal Inflammation

Nishimura, Hiroshi; Nagura, Yoko; Fukudo, Shin; Sasano, Hironobu

doi:10.1267/ahc.36.287

Cited by 1 publication

(1 citation statement)

References 42 publications

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“…PTSD is an anxiety disorder for certain severe psychological consequences of exposure to, or confrontation with, stressful events that a person experiences as highly traumatic. It has been reported that stress can lead to changes in the neuroendocrine system, thereby affecting the immune system and metabolic system [ 17 ]. In the neuroendocrine system, the hypothalamic-pituitary-adrenal axis (HPA-axis) is the most important, and glucocorticoid is the next most important factor.…”

Section: Introductionmentioning

confidence: 99%

Expressions of Hippocampal Mineralocorticoid Receptor (MR) and Glucocorticoid Receptor (GR) in the Single-Prolonged Stress-Rats

Han

Shi

2008

Acta Histochem. Cytochem.

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Post-traumatic stress disorder (PTSD) is a stress-related mental disorder caused by traumatic experience. Single-prolonged stress (SPS) is one of the animal models proposed for PTSD. Rats exposed to SPS showed enhanced inhibition of the hypothalamo-pituitaryadrenal (HPA) axis, which has been reliably reproduced in patients with PTSD. Mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the hippocampus regulate HPA axis by glucocorticoid negative feedback. Abnormalities in negative feedback are found in PTSD, suggesting that GR and MR might be involved in the pathophysiology of these disorders. In the present study, we performed immunohistochemistry and western blotting to examine the changes in hippocampal MR-and GR-expression after SPS. Immunohistochemistry revealed decreased MR-and GR-immunoreactivity (ir) in the CA1 of hippocampus in SPS animals. Change in GR sub-distribution was also observed, where GR-ir was shifted from nucleus to cytoplasm in SPS rats. Western blotting showed that SPS induced significantly decreased MR-and GR-protein in the whole hippocampus, although the degree of decreased expression of both receptors was different. Meanwhile, we also found the MR/GR ratio decreased in SPS rats. In general, SPS induced down-regulation of MR-and GRexpression. These findings suggest that MR and GR play critical roles in affecting hippocampal function. Changes in MR/GR ratio may be relevant for behavioral syndrome in PTSD.

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Section: Introductionmentioning

confidence: 99%