Neuroendocrine Hyperplasias and Tumors, Larynx and Trachea, Syrian Hamster

Ernst, Heinrich; Heinrichs, Martin; Bargsten, Gerhard; Kittel, Birgit; Rittinghausen, Susanne; Dungworth, D. L.; Möhr, U.

doi:10.1007/978-3-642-61042-4_10

Cited by 5 publications

(13 citation statements)

References 19 publications

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“…It is likely that the tumors arise from rests of C-cells which failed to migrate to the thyroid. The site of origin at the laryngotracheal junction, the morphology, and the immunohistochemistry of these cells appear to support this hypothesis (Ernst et al 1995). In our 24-month studies, tumors of the gastrointestinal system included adenoma of the glandular stomach, squamous cell papilloma and carcinoma of the forestomach, adenoma and adenocarcinoma of the salivary gland, and hemangiosarcoma and odontoma of the teeth.…”

Section: Discussionsupporting

confidence: 59%

“…The presence of spontaneous ectopic C-cell or neuroendocrine cell hyperplasia or benign or malignant tumors of these cells in the larynx (Pour 1985) or the trachea (Ernst et al 1995) may be unique to hamsters. The frequency varies considerably between colonies of hamsters (Mohr et al 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Ernst et al (1995) demonstrated that the neuroendocrine cells in these laryngeal and tracheal locations are positive for calcitonin and calcitonin gene-related peptide, neuron-specific enolase, and serotonin using immunohistochemistry. Benign tumors of neuroendocrine cells do not display invasion, whereas malignant tumors of these cells demonstrate submucosal and luminal invasion and metastasis to the lung (Ernst et al 1995). We favor the term ectopic C-cell hyperplasia/adenoma/ carcinoma rather than neuroendocrine cell hyperplasia/tumor since we consider the origin of these cells to be the C-cells from the thyroid.…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous Neoplastic Lesions in Control Syrian Hamsters in 6-, 12-, and 24-Month Short-Term and Carcinogenicity Studies

McInnes¹,

Ernst

Germann³

2012

Toxicol Pathol

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Male and female Syrian hamsters of the strain Han: AURA from the Fraunhofer Institute for Toxicology and Experimental Medicine breeding colony were maintained as control animals for five toxicity/carcinogenicity studies and were examined for the presence of neoplastic disease either when they died or when the study terminated. In total, 250 male animals and 250 female animals in three carcinogenicity studies were analyzed as well as the results of a 6-month study (fifty males and fifty females) and a 12-month study (fifty males and fifty females). In the 24-month studies, in the male animals, twenty-five organs were affected with malignant and benign tumors. In the female animals, twenty-four organs were affected with malignant and benign tumors. The most frequently affected tissue in the three 24-month studies was the adrenal gland where 141 cortical adenomas (56.4%) were noted in 250 male animals and 115 cortical adenomas (46%) noted in 250 female animals. In addition, a high incidence of squamous cell papilloma in the vagina was noted in female hamsters on the 24-month studies. A moderate incidence of squamous cell papilloma of the nonglandular forestomach, benign granulosa cell tumor of the ovary, lymphoma of the hemopoietic system, endometrial stromal polyp, and adenocarcinoma of the uterus and islet cell adenoma of the pancreas were also observed on the 24-month studies.

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Section: Discussionsupporting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Spontaneous Neoplastic Lesions in Control Syrian Hamsters in 6-, 12-, and 24-Month Short-Term and Carcinogenicity Studies

McInnes¹,

Ernst

Germann³

2012

Toxicol Pathol

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“…There are no obvious cytological differences between ectopic C cell hyperplasia and benign tumors at the laryngo-tracheal junction in hamsters and the diagnosis is largely based on size. Incidences of up to 8% in hamsters are reported (Ernst et al, 1995), but this incidence was not seen in present studies. The lesion could originate from solitary or clusters of neuroendocrine cells or it could originate from embryonic C cells (which is the hypothesis favored by the authors).…”

Section: Interesting Background Lesions In Hamsterscontrasting

confidence: 79%

“…In addition, neuroendocrine and ectopic C cells are positive with a silver stain (Grimelius) as shown in Figure 3I. Benign tumors of neuroendocrine cells do not display invasion, whereas malignant tumors demonstrate submucosal and luminal invasion and metastasis to the lung (Ernst et al, 1995). Since this tumor did not display invasion, the diagnosis of benign tumor was favored.…”

Section: Interesting Background Lesions In Hamstersmentioning

confidence: 99%

Proceedings of the 2013 National Toxicology Program Satellite Symposium

Elmore

Boyle

et al. 2013

Toxicol Pathol

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The 2013 annual National Toxicology Program (NTP) Satellite Symposium, entitled “Pathology Potpourri” was held in Portland, Oregon in advance of the Society of Toxicologic Pathology's 32nd annual meeting. The goal of the NTP Symposium is to present current diagnostic pathology or nomenclature issues to the toxicologic pathology community. This article presents summaries of the speakers' presentations, including diagnostic or nomenclature issues that were presented, along with select images that were used for audience voting and discussion. Some lesions and topics covered during the symposium included a caudal tail vertebra duplication in mice; nephroblastematosis in rats; ectopic C cell tumor in a hamster; granular cell aggregates/tumor in the uterus of a hamster; Pneumocystis carinii in the lung of a rat; iatrogenic chronic inflammation in the lungs of control rats; hepatoblastoma arising within an adenoma in a mouse; humoral hypercalcemia of benignancy in a transgenic mouse; acetaminophen induced hepatoxicity in rats; electron microscopy images of iatrogenic intraerythrocytic inclusions in transgenic mice; questionable hepatocellular degeneration/cell death/artifact in rats; atypical endometrial hyperplasia in rats; malignant mixed Müllerian tumors/carcinosarcomas in rats; differential diagnoses of proliferative lesions the intestine of rodents; and finally obstructive nephropathy caused by melamine poisoning in a rat.

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