Neuroendocrine cell populations in normal human lungs: a quantitative study.

Gosney, John R.; Sissons, M. C. J.; Allibone, R

doi:10.1136/thx.43.11.878

Cited by 58 publications

(59 citation statements)

References 21 publications

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“…Their morphology was typical of the endocrine cells of the normal mammalian lung (Gosney et al 1988a). The solitary variety were usually pyramidal and located on the epithelial basement lamina with the bulb of their cytoplasm deeply situated and their luminal aspect largely covered by adjacent epithelial cells (Figure 1).…”

Section: Resultsmentioning

confidence: 97%

Pulmonary endocrine cells in hypertensive pulmonary vascular disease

Heath¹,

Yacoub²,

Gosney³

et al. 1990

Histopathology

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A study was made of the number of pulmonary endocrine cells, immunoreactive for gastrin-releasing peptide (bombesin) or calcitonin, in the terminal bronchioles of 39 cases of pulmonary vascular disease. In 25 of these, the form of vascular disease was plexogenic pulmonary arteriopathy, primary in 12 and secondary in 13, while the remaining 14 subjects had a wide range of other varieties of hypertensive pulmonary vascular disease. We found that pulmonary endocrine cells, especially those containing bombesin, were increased in number in both the primary and secondary forms of plexogenic pulmonary arteriopathy but not in other varieties of pulmonary hypertension. The prominent bombesin-containing cells were found in cases with cellular plexiform lesions but occurred even more prominently at an earlier stage when vascular smooth muscle cells were migrating from the inner media into the intima.

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Section: Resultsmentioning

confidence: 97%

Pulmonary endocrine cells in hypertensive pulmonary vascular disease

Heath¹,

Yacoub²,

Gosney³

et al. 1990

Histopathology

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“…For example, pulmonary BN/GRP receptor levels in adult lung are extremely low or nonexistent under normal conditions (35,36). However, prolonged tobacco exposure, transformed cells, and lung cancer result in marked increases in pulmonary BN/GRP levels and the expression of their receptors (7,15,(37)(38)(39).…”

Section: Resultsmentioning

confidence: 99%

A New High Affinity Technetium Analogue of Bombesin Containing DTPA as a Pharmacokinetic Modifier

et al. 2004

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The bombesin (BN)/gastrin-releasing peptide (GRP) receptor is expressed in high density on the cell surface of a variety of tumors. This makes the receptors accessible as a molecular target for the detection of lesions in which they are expressed. In this study, we describe a high affinity hydrophilic (99m)Tc-labeled BN analogue, [DTPA(1), Lys(3)((99m)Tc-Hx-DADT), Tyr(4)]BN, having diethylenetriaminepentaacetic acid (DTPA), as a build-in pharmacokinetic modifier, to direct its excretion through the urinary system in order to lower abdominal background activity. In vitro binding studies using [(125)I-Tyr(4)]BN (K(d), 0.1 nM) and human prostate cancer PC-3 cell membranes showed that the inhibition constant (K(i)) of [DTPA(1), Lys(3)((99)Tc-Hx-DADT), Tyr(4)]BN was 19.9 +/- 8.0 nM. Biodistribution studies in normal mice showed fast blood clearance (0.15 +/- 0.01% ID/g, 4 h postinjection), low intestinal accumulation (9.16 +/- 2.35% ID/g, 4 h postinjection), and significant uptake in BN/GRP receptor rich tissues such as the pancreas (21.83 +/- 2.88% ID/g, 15 min postinjection). The pancreas/blood, pancreas/muscle, and pancreas/liver ratios were highest at 2 h postinjection at 23, 74, and 8.4, respectively. The uptake in the pancreas could be blocked by BN (11.96 +/- 1.17 vs 0.65 +/- 0.16% ID/g), partially blocked by neuromedin B (11.96 +/- 1.17 vs 6.66 +/- 0.51% ID/g), but not affected by somatostatin (11.96 +/- 1.17 vs 12.91 +/- 2.53% ID/g), indicating that the binding of [DTPA(1), Lys(3)((99m)Tc-Hx-DADT), Tyr(4)]BN to the receptors was specific. Scintigraphic imaging of human PC-3 prostate cancer xenografts in SCID mice gave a high target to nontarget ratio on the image. Thus, [DTPA(1), Lys(3)((99m)Tc-Hx-DADT), Tyr(4)]BN has the potential for imaging BN/GRP receptor-positive lesions.

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“…14 In the healthy adult, PNEC are sparsely distributed, with approximately 1 PNEC per 2500 epithelial cells. 15 The secretory granule-containing cells are typically tall and pyramidal in shape, extending from the basal lamina of the epithelium and possess apical microvilli projecting into the airway lumen. These microvilli function as the sensory part of the cell and upon stimulation, respond by degranulation and exocytosis of amines and neuropeptides, which exert a local paracrine and neurocrine effect on neighboring cells and activate both extrinsic and intrinsic neurons (Fig.…”

Section: Neuroendocrine System Of the Lungmentioning

confidence: 99%

Bronchopulmonary neuroendocrine tumors

Gustafsson

Kidd

Chan

et al. 2008

Cancer

444

340

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SCLC is the most common BP-NET, while LCNEC is rare, %10% and 1%, respectively, of all lung cancers. Both SCLC and LCNEC progress rapidly, are aggressively metastatic, and exhibit a poor prognosis. The incidence of BP-carcinoids (TC and AC) in the US was 1.57 of 100,000 in 2003 (an unexplained and substantial increase over the last 30 years, %6% per year). No curative treatment except for radical surgery (almost never feasible) exists. The slow-growing TC exhibit a fairly good prognosis (%88%, 5-year survival), whereas AC demonstrate a 5-year survival of %50%, and the highly malignant LCNEC and SCLC 5-year survival of 15% to 57% and <5%, respectively. This review provides a broad overview on BPNETs and focuses on the evolution of the disease, general features, and current diagnostic and therapeutic options.

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Neuroendocrine cell populations in normal human lungs: a quantitative study.

Cited by 58 publications

References 21 publications

Pulmonary endocrine cells in hypertensive pulmonary vascular disease

Pulmonary endocrine cells in hypertensive pulmonary vascular disease

A New High Affinity Technetium Analogue of Bombesin Containing DTPA as a Pharmacokinetic Modifier

Bronchopulmonary neuroendocrine tumors

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