Neuroendocrine Carcinomas of Diverse Sites

Osamura, R. Yoshiyuki; Inomoto, Chie; Kajiwara, Hiroshi; DeLellis, Ronald A.

doi:10.1097/01.pcr.0000251136.88078.43

Cited by 3 publications

(5 citation statements)

References 57 publications

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“…Neuroendocrine carcinomas are found in different tissues and organs, including those that do not normally contain neuroendocrine cells ( 8 ). Neuroendocrine tumors of the kidney are extremely rare neoplasms and include carcinoids, atypical carcinoids, and small cell carcinomas ( 9 ). The prognosis differs according to disease stage.…”

Section: Primary Malignant Neuroendocrine Tumor Of the Kidneymentioning

confidence: 99%

“…The peak incidence of neuroendocrine tumors occurs in patients in their 50s and 60s but patients as young as 12 years and those in their 70s have also been reported. Older age at the time of diagnosis (> 40 years) is correlated with an advanced disease stage and a worse prognosis ( 9 ). Surgical resection is the only known curative treatment, and the prognosis may be good even in patients with local lymph node involvement ( 10 ).…”

Section: Primary Malignant Neuroendocrine Tumor Of the Kidneymentioning

confidence: 99%

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Unusual Malignant Solid Neoplasms of the Kidney: Cross-Sectional Imaging Findings

et al. 2015

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Malignant kidney neoplasms are the most frequently encountered solid kidney masses. Although renal cell carcinoma is the major renal malignancy, other solid malignant renal masses should be considered in the differential diagnosis of solid renal masses that do not contain a macroscopic fatty component. In this pictorial essay, we present the imaging findings of a primitive neuroectodermal tumor, primary liposarcoma of the kidney, primary neuroendocrine tumor, leiomyosarcoma, synovial sarcoma, malignant fibrous histiocytoma, sclerosing fibrosarcoma and renal metastasis of osteosarcoma.

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Section: Primary Malignant Neuroendocrine Tumor Of the Kidneymentioning

confidence: 99%

Section: Primary Malignant Neuroendocrine Tumor Of the Kidneymentioning

confidence: 99%

Unusual Malignant Solid Neoplasms of the Kidney: Cross-Sectional Imaging Findings

et al. 2015

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“…Neuroendocrine carcinomas may originate in a wide variety of tissues and organs, including those that do not normally contain neuroendocrine cells [ 1 ]. These tumors may occur in pure forms or in association with conventional adenocarcinomas or squamous cell carcinomas [ 2 ]. Neuroendocrine tumors of the kidney include carcinoids, atypical carcinoids, and small cell carcinomas [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…These tumors may occur in pure forms or in association with conventional adenocarcinomas or squamous cell carcinomas [ 2 ]. Neuroendocrine tumors of the kidney include carcinoids, atypical carcinoids, and small cell carcinomas [ 2 ]. Intrarenal pheochromocytoma, neuroblastoma, and primitive neuroectodermal tumors may also occur [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…They may present clinically with gross hematuria or as a mass detected on imaging studies. NE lesions of the kidney are currently classified as well- or poorly-differentiated, both being extremely uncommon [ 2 , 4 ]. Well-differentiated neuroendocrine tumors of renal origin are usually carcinoids, and fewer than 56 cases have been reported in the literature [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Surgical treatment of a rare primary renal carcinoid tumor with liver metastasis

et al. 2008

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Background: Carcinoid tumors are characteristically low grade malignant neoplasms with neuroendocrine differentiation that arise in various body sites, most commonly the lung and gastrointestinal tract, but less frequently the kidneys, breasts, ovaries, testes, prostate and other locations. We report a case of a carcinoid of renal origin with synchronous single liver metastases on radiological studies.

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Combined Large Cell Neuroendocrine and Endometrioid Carcinoma of the Endometrium

Mulvany

Allen

2008

International Journal of Gynecological Pathology

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We present the surgical and pathological findings and follow-up of 5 women diagnosed with combined endometrioid and high-grade neuroendocrine carcinoma of large cell type (LCNEC) arising in the endometrium. The mean age of the women was 75 years (range, 50-88 years). Of the 5 tumors, 4 formed polypoid endometrial masses associated with extensive lymphovascular involvement of the myometrium by neoplastic cells. A single endometrial tumor was formed by LCNEC alone, and 4 tumors were composite with varying proportions formed by endometrioid (4/5) and small cell neuroendocrine carcinoma (1/5). In all 5 LCNEC tumor components, an insular growth pattern was noted, whereas a diffuse (solid) pattern was found in 4 tumors, a trabecular in 2, and rosettes/pseudorosettes in another 2. In all 5 tumors, the LCNEC tumor components were labeled with neuron-specific enolase (NSE). Four tumors were reactive for chromogranin A, CAM 5.2, and p53. Three tumors were labeled for AE1/AE3, CD56 (NCAM), p16, and cytokeratin 7. Synaptophysin was reactive in 2 tumors, and CD117 was found in only a single tumor. Of the 3 endometrioid tumor components examined, all were reactive for NSE. Two tumors were reactive for p16 and p53, 1 for CD56, but none for synaptophysin orchromogranin A. We conclude that LCNEC of the endometrium is a distinct clinicopathological entity with a poor prognosis irrespective of stage. The gross and histomorphological features are often suggestive, but confirmation requires immunoperoxidases, including NSE, synaptophysin, chromogranin A, p16, and p53. Combined endometrioid and high-grade LCNEC possess more characteristics of a type II than a type I endometrial carcinoma.

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Neuroendocrine Carcinomas of Diverse Sites

Cited by 3 publications

References 57 publications

Unusual Malignant Solid Neoplasms of the Kidney: Cross-Sectional Imaging Findings

Unusual Malignant Solid Neoplasms of the Kidney: Cross-Sectional Imaging Findings

Surgical treatment of a rare primary renal carcinoid tumor with liver metastasis

Combined Large Cell Neuroendocrine and Endometrioid Carcinoma of the Endometrium

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