Neuroendocrine carcinoma of the tongue

Yoshida, Hiroshi; Onizawa, Kojiro; Hirohata, Hiromi

doi:10.1016/0278-2391(95)90342-9

Cited by 21 publications

(13 citation statements)

References 20 publications

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“…Based on their histologic resemblance to neuroendocrine tumors of other organ systems, a spectrum of similar lesions has been reported as primary tumors in the oral cavity. These include small cell carcinoma (SCC) of Merkel cell type (29–34), SCC of pulmonary type (35–37), atypical carcinoid (38, 39), and large cell neuroendocrine carcinoma (NEC) (27). An algorithm for the typing of oral NEC is presented in Fig.…”

Section: Neuroendocrine Tumors Of the Oral Mucosamentioning

confidence: 99%

Neuroendocrine cells and associated malignancies of the oral mucosa: a review

Mahomed

2010

Journal of Oral Pathology &Amp; Medicine

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Neuroendocrine cells of the oral mucosa constitute an under-recognized component of the diffuse neuroendocrine system with diverse subpopulations and elusive biologic roles in the oral cavity. Primary malignant oral tumors that show a neuroendocrine phenotype display histomorphologic heterogeneity thereby giving rise to a spectrum of lesions in this rare category of oral malignancy. These lesions can be divided into neuroendocrine carcinomas (NECs) of small cell or non-small cell type. The former is further subdivided into the Merkel cell type or the pulmonary type while the latter includes atypical carcinoid tumor and large cell NEC. All histologic subtypes of oral NEC appear to have a strong predilection for men in their fifth or sixth decade and arise predominantly in the non-keratinized oral mucosa. The biologic behavior of oral Merkel cell carcinomas appears to be more aggressive than those of skin. It remains to be determined whether histologic categorization of the remaining tumor subtypes is predictive of patient survival in oral neuroendocrine tumors.

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Section: Neuroendocrine Tumors Of the Oral Mucosamentioning

confidence: 99%

Neuroendocrine cells and associated malignancies of the oral mucosa: a review

Mahomed

2010

Journal of Oral Pathology &Amp; Medicine

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“…[2] The tongue is an extremely rare site for NECs with only seven cases reported in literature till date. [3456789] However, due to the paucity of studies, no definite prognostic factors and treatment protocols are defined for these tumors in the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

Postradiotherapy small cell neuroendocrine carcinoma of base of tongue

Jha

Sharma

Yadav

et al. 2017

Journal of Postgraduate Medicine

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Small cell neuroendocrine carcinoma (NEC) of the tongue is an extremely rare entity with only seven cases reported in literature till date. These are high-grade tumors with a dismal prognosis. There is much ambiguity regarding the classification, treatment protocols and prognostic factors of these tumors due to the paucity of studies. We describe an exceptionally rare and unusual case of small cell NEC of the base of tongue arising in an elderly man 6 years after receiving radiotherapy for the treatment of squamous cell carcinoma at the same site. The diagnosis was confirmed on histopathological examination and supported by immunohistochemical positivity for neuron-specific enolase, synaptophysin, chromogranin, pan-cytokeratin, and cytokeratin 7. To the best of our knowledge, this is the first case of intraoral NEC arising many years later within the irradiated field of the initial tumor.

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“…SNEC of the head and neck exhibits a preference for males, with a peak incidence from the fifth to seventh decades of life, and occurs most frequently in men with a heavy smoking background (3)(4)(5)(6)(7)(8)(9). Patients typically present with painless masses and symptoms similar to other mucosal-based carcinomas at such sites.…”

Section: Introductionmentioning

confidence: 99%

“…The tumors usually develop rapidly over several months, and cervical nodal metastases are very common (3,9). Paraneoplastic manifestations have been described in a few cases (3,6,9).…”

Section: Introductionmentioning

confidence: 99%

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Primary small cell neuroendocrine carcinoma of the oral cavity: A case report and review of the literature

et al. 2015

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Abstract. Small cell neuroendocrine carcinoma (SNEC) of the oral cavity is a rare and distinctive tumor with aggressive clinical behavior. Thus far, only a small number of cases have been reported and no definitive standard treatment strategy has been determined. The current study reports a case of oral SNEC arising in the lower gingiva in a 73-year-old male. Computed tomography displayed a relatively well-defined mass measuring 2.8x2x1.4 cm in size. The mass was located in the buccal side of the right mandibular posterior gingiva and exhibited no bony involvement. Histopathological examination revealed a proliferation of small cells with ovoid-to spindle-shaped nuclei, fine granular chromatin, inconspicuous nucleoli, scant cytoplasm and high mitotic activity. Immunohistochemically, the tumor cells were positive for cytokeratin AE1/AE3, chromogranin A, synaptophysin and neuron-specific enolase. Surgical resection and radical neck dissection were performed prior to the administration of adjuvant chemotherapy with a combination of cisplatin and etoposide. No evidence of local recurrence or metastasis was observed at 14 months post-surgery.

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Neuroendocrine carcinoma of the tongue

Cited by 21 publications

References 20 publications

Neuroendocrine cells and associated malignancies of the oral mucosa: a review

Neuroendocrine cells and associated malignancies of the oral mucosa: a review

Postradiotherapy small cell neuroendocrine carcinoma of base of tongue

Primary small cell neuroendocrine carcinoma of the oral cavity: A case report and review of the literature

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