Neuroendocrine carcinoma of the cervix during pregnancy: A case report

Teefey, Patrick; Orr, Brian; Vogt, M.; Roberts, William S.

doi:10.1016/j.gynor.2012.03.003

Cited by 10 publications

(9 citation statements)

References 8 publications

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“…It is as low as 0.31–3% according to literature [1, 2]. Until now 18 cases were reported about small cell neuroendocrine cervical cancer that occurred during pregnancy [3–18]. Table 1 lists the features of all the 18 cases.…”

Section: Discussionmentioning

confidence: 99%

“…Her first-order cousin had cervical cancer at age 22, and the maternal grandmother died of cervical cancer [14]. The youngest gestational age was just 10 weeks and the patient remained adamant about preserving the pregnancy; then she had neoadjuvant chemotherapy (NACT) of 4 cycles and delivered at 36 weeks [3]. Only one newborn out of eighteen was dead on day 27 of life [14].…”

Section: Discussionmentioning

confidence: 99%

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Small Cell Neuroendocrine Carcinoma of the Cervix in Pregnancy: A Case Report and Review

Pan

Liu

Sheng

et al. 2019

Case Reports in Obstetrics and Gynecology

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Small cell neuroendocrine carcinoma of the cervix is a rare subtype of cervical cancer. Here we report a case in which a 27-year-old female patient presented at 34-week gestation with abnormal vaginal bleeding, underwent normal labor, and gave birth to a healthy neonate. Her pregnancy was complicated with a cervical tumor which turned out to be small cell neuroendocrine cervical carcinoma. We reviewed and discussed the features, diagnosis, and prognosis of small cell neuroendocrine carcinoma of the cervix.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Small Cell Neuroendocrine Carcinoma of the Cervix in Pregnancy: A Case Report and Review

Pan

Liu

Sheng

et al. 2019

Case Reports in Obstetrics and Gynecology

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“…Nine of the 10 patients diagnosed after 25 weeks’ gestational age underwent elective cesarean section followed by a radical hysterectomy or chemotherapy. Teefey et al 7 reported a case of SCCC during pregnancy diagnosed at 10 weeks’ gestation, and they performed neoadjuvant chemotherapy with etoposide and cisplatin (EP/PE) because the patient declined a radical hysterectomy. In the present case, we initially performed a radical hysterectomy considering the gestational age at diagnosis and the estimated 10% 5-year survival rate which we calculated from the 10 above-mentioned cases.…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, this is the first report of a radical hysterectomy for SCCC during pregnancy. Since 1990, 10 cases of SCCC during pregnancy [5][6][7] were reported in the English literature (Table 1). The initial treatment option depended on whether or not the fetus had extrauterine survival potential.…”

Section: Discussionmentioning

confidence: 99%

Small cell carcinoma of the uterine cervix during pregnancy

Eto

Kai²,

Nasu

et al. 2019

Rare Tumors

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Small cell carcinoma of the uterine cervix is a rare histological entity that has a poor prognosis. We report the case of a patient with small cell carcinoma of the uterine cervix who underwent a radical hysterectomy during pregnancy. A 33-year-old Japanese woman with genital bleeding was referred at 15 weeks’ gestation. A speculum exam revealed a 5.4-cm-dia. mass in the cervix, and a cervical biopsy revealed small cell carcinoma of the uterine cervix. Imaging studies demonstrated a tumor confined to the cervix, swelling of intra-pelvic lymph nodes, and no distant spread of the tumor. She was diagnosed as having small cell carcinoma of the uterine cervix, stage IB2, and underwent a radical hysterectomy with pelvic lymphadenectomy. She refused any adjuvant therapies, had a systemic relapse 4 months after surgery, and died of the disease 5 months after surgery. Early-stage small cell carcinoma of the uterine cervix should be treated with a definitive therapy soon after diagnosis whether the patient is pregnant or not. Saving the mother’s life should be the top priority.

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“…Several studies have shown small cell carcinoma of the uterine cervix to represent fewer than 2% of all invasive cervical cancers [ 8 , 9 ]. Some small series and individual case reports of patients with cervical small cell carcinoma are known in the literature; however, only very rare reports of this disease being initially diagnosed in gravid cervices are known [ 10 – 13 ]. Establishing a definitive diagnosis of this aggressive malignancy by cervicovaginal cytology testing alone can be especially challenging, as ancillary studies (such as immunocytochemistry) are commonly employed in confirming a specific diagnosis [ 14 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

Small Cell Carcinoma of the Uterine Cervix in a Pregnant Patient Diagnosed with Liquid Based Cytology and Cell Block Immunocytochemistry

Attipoe

Sturgis

2014

Case Reports in Pathology

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Definitive cytomorphologic diagnosis of small cell carcinoma of the uterine cervix is possible but can be challenging in routine cervicovaginal cancer screening specimens. Several small series of reported cases of cervical small cell carcinoma have shown this uncommon malignancy to represent fewer than 2% of all invasive cervical cancers. This tumor type is associated with poor prognosis and rapid disease progression and can develop to an advanced stage in the interval between screening visits. Only rare case reports of small cell carcinoma arising in gravid cervices are known. In the current case a 29-year-old, gravida 6, para 2, pregnant (10-week gestation) female presented with postcoital bleeding. A definitive diagnosis of small cell carcinoma of the cervix was made possible by liquid based Pap testing with ancillary cell block preparation allowing for immunocytochemical characterization of the lesional cell population.

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Neuroendocrine carcinoma of the cervix during pregnancy: A case report

Abstract: ► Neuroendocrine carcinoma of the cervix is a rare and aggressive malignancy. ► A multimodality approach must be individualized when diagnosed during pregnancy. ► We report the use of a therapeutic cervical cone and adjuvant chemotherapy.

Cited by 10 publications

References 8 publications

Small Cell Neuroendocrine Carcinoma of the Cervix in Pregnancy: A Case Report and Review

Small Cell Neuroendocrine Carcinoma of the Cervix in Pregnancy: A Case Report and Review

Small cell carcinoma of the uterine cervix during pregnancy

Small Cell Carcinoma of the Uterine Cervix in a Pregnant Patient Diagnosed with Liquid Based Cytology and Cell Block Immunocytochemistry

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