Neuroendocrine and Behavioral Effects of Repetitive Transcranial Magnetic Stimulation in a Psychopathological Animal Model Are Suggestive of Antidepressant-like Effects

Keck, Martin E.; Welt, Tobias; Post, Anke; Müller, Marianne B.; Toschi, Nicola; Wigger, A.; Landgraf, Rainer; Holsboer, Florian; Engelmann, Mario

doi:10.1016/s0893-133x(00)00191-3

Cited by 128 publications

(69 citation statements)

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“…The HAB and LAB rat lines, differing markedly in their inborn anxiety-related and acute stress coping behaviors (Liebsch et al 1998a,b;Keck et al 2001a), provide a promising tool for investigating the relationship between inborn emotionality, acute stress coping, physiological and neuroendocrine stress responses and their underlying mechanisms ). Thus, studies on aberrant patterns in these selected laboratory animals genetically predisposed to certain behavioral strategies may contribute to a better understanding of human psychopathology states.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, earlier studies showed a similar response of pituitary corticotropes to an i.v. CRH challenge in male HAB and LAB rats Keck et al 2001a).…”

Section: Aberrant Outcome Of the Combined Dex/crh Test In Male Hab Ratsmentioning

confidence: 98%

“…Furthermore, earlier studies showed a similar response of pituitary corticotropes to an i.v. CRH challenge in male HAB and LAB rats Keck et al 2001a).The aberrant outcome of the DEX/CRH test was gender-dependent as the female HAB rats were found to be indistinguishable from the female LAB rats when tested during the proestrus/estrus phase of their estrous cycle. Thus, in females DEX-suppression of ACTH secretion could be found in both HAB and LAB rats.…”

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confidence: 90%

“…These animals were bred for either high (HAB) or low (LAB) anxiety-related behavior on exposure to the elevated plus-maze (EPM), one of the most widely used non-conditioned tests of rodent anxiety. However, males and females of the two rat lines differ not only in their inborn anxiety as revealed by a variety of behavioral paradigms Neumann et al 1998b;Henniger et al 2000;Ohl et al 2001), but also in their stress coping strategies in that HAB rats show markedly passive stress coping in the forced swim test Keck et al 2001a). The forced swim test is considered to have predictive value for the efficacy of antidepressant treatments in humans (review : Lucki 1997).…”

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confidence: 99%

“…The forced swim test is considered to have predictive value for the efficacy of antidepressant treatments in humans (review : Lucki 1997). Therefore, it is the passive stress coping behavior that renders HAB animals a valuable model for investigating potentially antidepressant treatment strategies such as chronic paroxetine treatment (Keck, unpublished observation), transcranial magnetic stimulation (Keck et al 2001a) and the high-affinity CRH1 receptor antagonist R121919 (Keck et al 2001b). Interestingly, the high emotionality of HAB rats is accompanied by an increased HPA system susceptibility to external stressors (Landgraf et al 1999).…”

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confidence: 99%

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Vasopressin Mediates the Response of the Combined Dexamethasone/CRH Test in Hyper-anxious Rats Implications for Pathogenesis of Affective Disorders

Keck

Wigger

Welt

et al. 2002

Neuropsychopharmacology

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To investigate the neuroendocrine alterations linked to inborn emotionality in two Wistar rat lines selectively bred for either high (HAB) or low (LAB) anxiety-related behavior, we administered the combined dexamethasone (DEX)/corticotropin-releasing hormone (CRH)testNeuroendocrine studies provide strong indications that hyperactivity of central corticotropin-releasing hormone (CRH) circuits, resulting in a characteristic dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) system, plays a causal role in the symptomatology of affective and anxiety disorders (review: Keck and Holsboer 2001). The effects of CRH are modulated by vasopressin (AVP), which, after prolonged stress and in senescence, is increasingly coexpressed and secreted from hypothalamic CRH neurons in both humans and rodents (Antoni 1993;Tilders et al. 1993;Hatzinger et al. 2000;Keck et al. 2000). Similarly, increased numbers of CRH neurons that coexpress AVP mRNA have been found in the hypothalamus of depressed patients (Raadsheer et al. 1993;Purba et al. 1996). The excessive release of CRH and AVP into hypophysial portal blood is thought to increase the secretion of corticotropin (ACTH) from pituitary corticotrope cells, and this in turn to increase the release of corticosteroids from the adrenal gland. In this context, a variety of changes in HPA system regulation have been demonstrated in psychiatric disorders such as major depression, among them defective negative feedback of the HPA system, basal hypercortisolemia, inappropriate HPA suppression by the synthetic corticosteroid dexamethasone (DEX) and a paradoxical stimulation of ACTH secretion by CRH after DEX pretreatment (review: Holsboer and Barden 1996;Holsboer 2000). In depression, the combined DEX/CRH test, in which DEX-pretreated subjects receive a single dose of CRH, has proven to be the most sensitive tool for the detection of altered HPA regulation. Depending on age and gender, up to 90% of patients with depression show this neuroendocrine phenomenon (Heuser et al. 1994). Moreover, studies using the DEX/CRH test not only agree that normalization of an initial aberrance is predictive of a favorable treatment response but also corroborate other evidence that a persistent HPA abnormality correlates with chronicity or relapse (Heuser et al. 1996;Zobel et al. 1999). Since activation of corticosteroid receptors suppresses the synthesis and release of CRH and AVP from the hypothalamic paraventricular nucleus (PVN) , these findings are consistent with the hypothesis of functionally impaired corticosteroid receptor signaling in both depressed patients (Modell et al. 1997) and healthy subjects at genetic risk for depression Modell et al. 1998).As the mechanisms underlying the abnormal HPA reactivity in patients with certain psychiatric disorders are not fully understood, animal models are needed to further investigate the hypothesized linkage between these disorders and changes in the regulation of the HPA system. After several generations of selective breeding, we could establish ...

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, earlier studies showed a similar response of pituitary corticotropes to an i.v. CRH challenge in male HAB and LAB rats Keck et al 2001a).…”

Section: Aberrant Outcome Of the Combined Dex/crh Test In Male Hab Ratsmentioning

confidence: 98%

mentioning

confidence: 90%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Vasopressin Mediates the Response of the Combined Dexamethasone/CRH Test in Hyper-anxious Rats Implications for Pathogenesis of Affective Disorders

Keck

Wigger

Welt

et al. 2002

Neuropsychopharmacology

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157

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Effects of pulsed magnetic stimulation on tumor development and immune functions in mice

Yamaguchi

Ogiue-Ikeda

Sekino

et al. 2005

Bioelectromagnetics

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We investigated the effects of pulsed magnetic stimulation on tumor development processes and immune functions in mice. A circular coil (inner diameter = 15 mm, outer diameter = 75 mm) was used in the experiments. Stimulus conditions were pulse width = 238 micros, peak magnetic field = 0.25 T (at the center of the coil), frequency = 25 pulses/s, 1,000 pulses/sample/day and magnetically induced eddy currents in mice = 0.79-1.54 A/m(2). In an animal study, B16-BL6 melanoma model mice were exposed to the pulsed magnetic stimulation for 16 days from the day of injection of cancer cells. A tumor growth study revealed a significant tumor weight decrease in the stimulated group (54% of the sham group). In a cellular study, B16-BL6 cells were also exposed to the magnetic field (1,000 pulses/sample, and eddy currents at the bottom of the dish = 2.36-2.90 A/m(2)); however, the magnetically induced eddy currents had no effect on cell viabilities. Cytokine production in mouse spleens was measured to analyze the immunomodulatory effect after the pulsed magnetic stimulation. tumor necrosis factor (TNF-alpha) production in mouse spleens was significantly activated after the exposure of the stimulus condition described above. These results showed the first evidence of the anti-tumor effect and immunomodulatory effects brought about by the application of repetitive magnetic stimulation and also suggested the possible relationship between anti-tumor effects and the increase of TNF-alpha levels caused by pulsed magnetic stimulation.

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Effects of prenatal exposure to a 50‐Hz magnetic field on one‐trial passive avoidance learning in 1‐day‐old chicks

Sun

Che

Liu

et al. 2009

Bioelectromagnetics

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We investigated memory impairment in newly hatched chicks following in ovo exposure to a 50-Hz magnetic field (MF) of 2 mT (60 min/day) on embryonic days 12-18. Isolated and paired chicks were used to test the effect of stress during training, and memory retention was tested at 10, 30, and 120 min, following exposure to a bitter-tasting bead (100% methylanthranilate). Results showed that memory was intact at 10 min in both isolated and paired chicks with or without MF exposure. However, while isolated chicks had good memory retention levels at 30 and 120 min, those exposed to MF did not. The results suggest a potential disruption of memory formation following in ovo exposure to MF, with this effect only evident in the more stressed, isolated chicks.

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Neuroendocrine and Behavioral Effects of Repetitive Transcranial Magnetic Stimulation in a Psychopathological Animal Model Are Suggestive of Antidepressant-like Effects

Abstract: The neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation (rTMS) were investigated in two rat

Cited by 128 publications

References 38 publications

Vasopressin Mediates the Response of the Combined Dexamethasone/CRH Test in Hyper-anxious Rats Implications for Pathogenesis of Affective Disorders

Vasopressin Mediates the Response of the Combined Dexamethasone/CRH Test in Hyper-anxious Rats Implications for Pathogenesis of Affective Disorders

Effects of pulsed magnetic stimulation on tumor development and immune functions in mice

Effects of prenatal exposure to a 50‐Hz magnetic field on one‐trial passive avoidance learning in 1‐day‐old chicks

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