Neuroendocrine Abnormalities in Drug Abusers and HIV-Infected Individuals: Cortisol Response to Cold Pressor Challenge

Kumar, Mahendra; Waldrop-Va, Drenna; Kumar, Adarsh

doi:10.3844/ajidsp.2006.136.140

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…This HPA axis profile is worth comment. First, the greater ACTH reactivity, which represents the central drive by the pituitary on the adrenal cortex, in combination with blunted CORT reactivity, suggests possible impairment in negative feedback mechanisms regulating homeostasis of the HPA axis (Kumar et al, 2006). This HPA axis pattern was common to both those with perinatal depression and those with a history of ALEs suggesting a potential shared mechanism of risk that links a history of ALEs to PND.…”

Section: Discussionmentioning

confidence: 99%

Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Lara-Cinisomo

Grewen

Girdler

et al. 2017

Women's Health Issues

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Background Latinas are disproportionately affected by perinatal depression (PND) as well as by adverse life events (ALEs), an independent predictor of PND. Dysregulation of the hypothalamic-adrenal-pituitary (HPA) axis has been seen both in women with PND and with a history of ALEs in non-Latinas. Though some evidence suggests that HPA axis dysregulation may mediate the link between ALEs and PND, this has received little attention and there are no studies that have examined these pathways in Latinas. The primary aim of the present study was to explore, in a Latina sample, associations between ALEs, PND, and HPA axis stress reactivity to a physical stressor-the cold pressor test (CPT). The secondary aim was to explore whether HPA axis reactivity and PND were associated with pain sensitivity to the CPT. Methods Thirty-four Latinas were enrolled in their third trimester of pregnancy and interviewed at 4 and 8 weeks postpartum. Depression status was determined using the Edinburgh Postnatal Depression Scale (≥ 10). At 8 weeks postpartum, 27 women underwent laboratory-induced pain testing using the cold pressor test (CPT). Plasma adrenocorticotropic hormone (ACTH) and cortisol (CORT) were sampled pre- and post-CPT to generate a stress reactivity score (post-pre). Pain sensitivity and ALEs were also assessed. Results At enrollment, 26% of women were depressed and 18% were depressed at 8 weeks postpartum. Forty-eight percent reported at least one childhood ALE. There was a significant and positive association between any childhood ALE and prenatal depression scores (p = 0.025). Infant-related ALEs were significantly associated with greater ACTH reactivity to the CPT (p = 0.030). Women with a history of any childhood ALE exhibited a blunted CORT response to the CPT (p = 0.045). Women with a history of PND at 4 weeks had greater ACTH stress reactivity to the CPT (p = 0.027). No significant effects of PND were seen for pain sensitivity measures in response to the CPT, though there was a positive and significant correlation between pain tolerance and CORT response to the CPT in the whole sample. Conclusions Given the associations between ALEs and PND and their individual effect on HPA axis stress reactivity, future studies on perinatal depression should include a larger sample of Latinas to test mediating effects of HPA axis reactivity on associations between ALEs and PND.

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Section: Discussionmentioning

confidence: 99%

Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Lara-Cinisomo

Grewen

Girdler

et al. 2017

Women's Health Issues

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“…She suggested that modification of the drug-induced hormonal dysfunction might represent a treatment strategy for drug rehabilitation. Kumar [6] described neuroendocrine abnormalities in HIV-infected drug abusers. He stated that since IDU was an important risk factor for becoming infected with HIV, it is possible that substance use also might be be associated with endocrine dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Hormonal and Metabolic Disorders of Human Immunodeficiency Virus Infection and Substance Abuse

Khalsa

Vocci²,

Dobs³

2006

American J. of Infectious Diseases

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Abstract:There are an estimated 200 million users of an illicit drug in the world today. In addition, an estimated 40 million people are infected with the human immunodeficiency virus (HIV) and an estimated 180 million people are infected with the hepatitis C virus (HCV). Both the use of an illicit drug and the co-occurrence of infections are associated with a multitude of medical and health consequences including hormonal and metabolic disorders. Thus, the National Institute on Drug Abuse (NIDA), a part of the National Institutes of Health (NIH) hosted a workshop on hormonal and metabolic disorders of HIV among substance abusers. A number of clinicians and scientists participated and discussed a wide range of issues concerning hormones, nutrition and metabolic complications in HIV and substance abuse. Their observations and the recommendations they made for future research are presented in these proceedings. The readers are encouraged to contact the NIH staff (JK, FV) for technical guidance and programmatic priorities on the subject and directly contact the individual authors for collaborations.

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Neuroendocrine Abnormalities in Drug Abusers and HIV-Infected Individuals: Cortisol Response to Cold Pressor Challenge

Cited by 2 publications

References 24 publications

Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Perinatal Depression, Adverse Life Events, and Hypothalamic–Adrenal–Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study

Hormonal and Metabolic Disorders of Human Immunodeficiency Virus Infection and Substance Abuse

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