Neurodevelopmental Toxicity Risks Due to Occupational Exposure to Industrial Chemicals during Pregnancy

Júlvez, Jordi; Grandjean, Philippe

doi:10.2486/indhealth.47.459

Cited by 76 publications

(46 citation statements)

References 41 publications

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“…Based on available information, we estimate that wells #1-5 were installed in the late 1960s/early 1970s, well #6 was installed in the 1990s as the population increased, and wells #7 and 8 were installed in 2014 and 2016, respectively. In 2016, five wells (#4, 5,6,7,8) were used to withdraw groundwater for public drinking water (Figure 1). Well #8 was added at the same location as #2, and seems to have replaced it.…”

Section: Study Area and Drinking Water Supplymentioning

confidence: 99%

“…Importantly, there is epidemiologic evidence that all four of these chemicals are neurotoxic individually, in particular following excess exposure that occurs prenatally or during early life [4][5][6][7][8][9][10]. Complicating this further is the potential for synergism between chemicals; however, little is known about how exposure to chemical mixtures impacts health [11].…”

Section: Introductionmentioning

confidence: 99%

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Integrated Assessment of Shallow-Aquifer Vulnerability to Multiple Contaminants and Drinking-Water Exposure Pathways in Holliston, Massachusetts

Henn

Ogneva‐Himmelberger

Denehy³

et al. 2017

Water

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Half of U.S. drinking water comes from aquifers, and very shallow ones (<20 feet to water table) are especially vulnerable to anthropogenic contamination. We present the case of Holliston, a Boston, Massachusetts suburb that draws its drinking water from very shallow aquifers, and where metals and solvents have been reported in groundwater. Community concerns focus on water discolored by naturally occurring manganese (Mn), despite reports stating regulatory aesthetic compliance. Epidemiologic studies suggest Mn is a potentially toxic element (PTE) for children exposed by the drinking-water pathway at levels near the regulatory aesthetic level. We designed an integrated, community-based project: five sites were profiled for contaminant releases; service areas for wells were modeled; and the capture zone for one vulnerable well was estimated. Manganese, mercury, and trichloroethylene are among 20 contaminants of interest. Findings show that past and/or current exposures to multiple contaminants in drinking water are plausible, satisfying the criteria for complete exposure pathways. This case questions the adequacy of aquifer protection and monitoring regulations, and highlights the need for integrated assessment of multiple contaminants, associated exposures and health risks. It posits that community-researcher partnerships are essential for understanding and solving complex problems.

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Section: Study Area and Drinking Water Supplymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Integrated Assessment of Shallow-Aquifer Vulnerability to Multiple Contaminants and Drinking-Water Exposure Pathways in Holliston, Massachusetts

Henn

Ogneva‐Himmelberger

Denehy³

et al. 2017

Water

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“…Environmental pollution by heavy metals that are produced by the combustion of hydrocarbons is a public health problem, which affects different organs such as central nervous system [91] have resulted in behavior, learning, mental disorders, attention deficit and low mental performance [92][93][94].…”

Section: Metals and Mental Healthmentioning

confidence: 99%

Health Effects of Metals in Particulate Matter

Fortoul¹,

Rodríguez-Lara²,

González-Villalva³

et al. 2015

Current Air Quality Issues

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“…Además, en los fetos la barrera hematoencefálica no se encuentra completamente desarrollada pues ésta termina su desarrollo después del nacimiento, 22 y debido a que el cerebro continúa su desarrollo durante la etapa posnatal, el periodo de vulnerabilidad se prolonga. Se ha reportado que ratones recién nacidos expuestos a dosis bajas de agentes neurotóxicos, como el insecticida paraquat, no muestran efectos inmediatos; sin embargo en la edad adulta presentan cambios conductuales y deficiencias en el aprendizaje, lo que se ha interpretado como una consecuencia de los daños cerebrales provocados por la exposición temprana a esta substancia.…”

Section: Grandjean Y Landriganunclassified

Efecto de la exposición al pesticida rotenona sobre el desarrollo del sistema dopaminérgico nigro-estriatal en ratas

et al. 2013

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La rotenona es un pesticida utilizado en México a pesar de que se ha demostrado experimentalmente que produce una degeneración de las neuronas dopaminérgicas, y puede derivar en deterioro psicomotor. Sin embargo, no existen estudios de la exposición indirecta a rotenona a través de las madres en el efecto que produzca sobre su descendencia. Nosotros administramos rotenona a ratas durante la gestación y la lactancia para evaluar las alteraciones producidas sobre las neuronas dopaminérgicas y la coordinación motora de sus crias, a los 30 o 60 días posnatales. Para cuantificar las neuronas inmunorreactivas a tirosina hidroxilasa de la sustancia nigra, se inyectaron subcutaneamente seis grupos de hembras Wistar: intactas (control), con solvente de rotenona (vehículo) y cuatro grupos con rotenona en dosis: 0.2, 0.4, 0.6 y 1.0 mg/kg/dia. En un experimento paralelo, las crías de otros grupos de hembras tratadas con rotenona 1 mg/kg/dia o controles fueron evaluados en la prueba de coordinación motora a los 30 y 60 dias posnatales. Las madres tratadas con 1 mg/kg de rotenona tuvieron menos neuronas dopaminérgicas en la sustancia nigra. Dicho efecto se observo también en las crías, pero con todas las dosis de rotenona utilizadas, tanto a los 30 como a los 60 días posnatales. Además, la exposición indirecta a rotenona aumento significativamente el tiempo que requirieron las crías para ejecutar la prueba de coordinación motora. Estos datos indican que la rotenona es capaz de inducir daño en las neuronas dopaminérgicas de las crías cuando son expuestas a través de sus madres. Este efecto en las crías se observa con dosis menores de rotenona que en ratas adultas. Por lo tanto, los individuos indirectamente expuestos a rotenona podrían tener menos neuronas dopaminérgicas desde etapas tempranas de la vida, lo que aumenta el riesgo de desarrollar trastornos relacionados con el sistema dopaminérgico.

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Neurodevelopmental Toxicity Risks Due to Occupational Exposure to Industrial Chemicals during Pregnancy

Cited by 76 publications

References 41 publications

Integrated Assessment of Shallow-Aquifer Vulnerability to Multiple Contaminants and Drinking-Water Exposure Pathways in Holliston, Massachusetts

Integrated Assessment of Shallow-Aquifer Vulnerability to Multiple Contaminants and Drinking-Water Exposure Pathways in Holliston, Massachusetts

Health Effects of Metals in Particulate Matter

Efecto de la exposición al pesticida rotenona sobre el desarrollo del sistema dopaminérgico nigro-estriatal en ratas

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