Neurodevelopmental Outcomes in Infants With Birth Weight ≤500 g at 3 Years of Age

Inoue, Hirosuke; Ochiai, Masayuki; Sakai, Yasunari; Yasuoka, Kazuaki; Tanaka, Kōichi; Ichiyama, Masako; Kurata, Hiroaki; Fujiyoshi, Junko; Matsushita, Yuki; Honjo, Satoshi; Nonaka, Kenichi; Taguchi, Tomoaki; Kato, Kiyoko; Ohga, Shouichi

doi:10.1542/peds.2017-4286

Cited by 18 publications

(22 citation statements)

References 38 publications

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“…On the other hand, many unsolved problems remain: NEC, cholestasis, neurodevelopmental impairment, short stature, risk for lifestylerelated diseases, etc. (7,(22)(23)(24)(25)(26). Not only the lung and brain, but also the gastrointestinal tract, liver, and kidney should be restored for the following life.…”

Section: Discussionmentioning

confidence: 99%

Case Report: Treatment of Extremely Preterm Infants With Birthweight Below 300 g: Case Series

et al. 2021

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Reports on the birth of infants weighing <300 g are quite rare and little is known about the best practices in treating such micropreemies. Therefore, we report here on three cases of low birthweight infants weighing <300 g, of whom two infants survived. The birthweights and gestational ages were ranging 279–293 g and 22 + 6/7 – 23 + 6/7 weeks, respectively. All the infants had severe fetal growth restriction and prematurity. The infant in case 1 died of hepatic rupture, perhaps due to birth trauma, which emphasized the need for less invasive obstetric procedures including en caul delivery. The infant in case 2 managed to survive through severe prematurity secondary to hydrops fetalis. However, complications followed soon as tracheal granulation tissue was formed with neurodevelopmental impairment. The infant in case 3 was born recently and her clinical course was less remarkable without severe complications, despite having the least gestational age and birthweight among the three patients. The improved care protocols for extremely low birthweight infants over these years through experiential learning including that with cases 1 and 2 may have ensured the better outcome of case 3. Accumulating evidence and recording the experience of such cases with continuous constructive discussion can contribute to better outcomes and appropriate parental counseling for extremely small babies in the future.

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Section: Discussionmentioning

confidence: 99%

Case Report: Treatment of Extremely Preterm Infants With Birthweight Below 300 g: Case Series

et al. 2021

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“…The brain damage in early life does influence the prognosis of affected children. Hirosuke and his colleagues investigated 3-year-old children's neurodevelopmental outcomes who were born <500 g. Through follow-up visits and data analyses of these survivals, their group made a great discovery that cystic periventricular leukomalacia, a severe category of brain damage in premature infants, was the high risk factor for neurological consequences (adjusted RR:1.40; 95%CI:1.13–1.73; P < 0.01) ( 4 ). So we will first focus on hypoxic-ischemic encephalopathy (HIE), an important component of the brain damage.…”

Section: Circrnas As Potential Biomarkers For Neurological Impairments and Diseasesmentioning

confidence: 99%

“…Generally speaking, the lower the gestational age (GA) and birth weight (BW) are, alone or combined, the higher the morbidity of brain damage is, and so is the mortality ( 3 ). A previous study has shown that premature birth does play an important role ( 4 ). Prematurity may greatly affect the integrity of brain structure and function, as well as health and development of further life ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

A Narrative Review of Circular RNAs in Brain Development and Diseases of Preterm Infants

Liu

et al. 2021

Front. Pediatr.

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Circular RNAs (circRNAs) generated by back-splicing are the vital class of non-coding RNAs (ncRNAs). Circular RNAs are highly abundant and stable in eukaryotes, and many of them are evolutionarily conserved. They are blessed with higher expression in mammalian brains and could take part in the regulation of physiological and pathophysiological processes. In addition, premature birth is important in neurodevelopmental diseases. Brain damage in preterm infants may represent the main cause of long-term neurodevelopmental disorders in surviving babies. Until recently, more and more researches have been evidenced that circRNAs are involved in the pathogenesis of encephalopathy of premature. We aim at explaining neuroinflammation promoting the brain damage. In this review, we summarize the current findings of circRNAs properties, expression, and functions, as well as their significances in the neurodevelopmental impairments, white matter damage (WMD) and hypoxic-ischemic encephalopathy (HIE). So we think that circRNAs have a direct impact on neurodevelopment and brain injury, and will be a powerful tool in the repair of the injured immature brain. Even though their exact roles and mechanisms of gene regulation remain elusive, circRNAs have potential applications as diagnostic biomarkers for brain damage and the target for neuroprotective intervention.

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“…Additionally, the development of infants weighing ≤ 300 g has only been mentioned in two articles. Two of the three infants weighing ≤ 300 g included in a Japanese cohort study between 2003 and 2012 were diagnosed with neurodevelopmental impairment at the age of 3 years 10 .…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Respiratory and Gastrointestinal Management of an Infant with a Birth Weight of 258 Grams

Itoshima

Oda

Ogawa

et al. 2021

AJP Rep

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Background: Nowadays, more infants weighing ≤ 300 g are born, and they survive because of the improvements in neonatal care and treatment. However, their detailed clinical course and neonatal intensive care unit management remain unknown due to their low survival rate and dearth of reports. Case Presentation: A male infant was born at 24 weeks and 5 days of gestation and weighed 258 g. The infant received 72 days of invasive and 92 days of noninvasive respiratory support, including high-frequency oscillatory ventilation with volume guarantee and noninvasive neurally adjusted ventilatory assist. Meconium-related ileus was safely treated using diatrizoate. Although he was diagnosed with severe bronchopulmonary dysplasia and retinopathy of prematurity requiring laser photocoagulation, he had no other severe complications. He was discharged 201 days post-delivery (3 months of corrected age) with a weight of 3396 g. Conclusions: Although managing infants weighing ≤ 300 g is difficult, our experience shows that it is possible by combining traditional and modern management methods. The management of such infants requires an understanding of the expected difficulties and adaptation of existing methods to their management. The management techniques described here should help improve their survival and long-term prognosis.

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Neurodevelopmental Outcomes in Infants With Birth Weight ≤500 g at 3 Years of Age

Cited by 18 publications

References 38 publications

Case Report: Treatment of Extremely Preterm Infants With Birthweight Below 300 g: Case Series

Case Report: Treatment of Extremely Preterm Infants With Birthweight Below 300 g: Case Series

A Narrative Review of Circular RNAs in Brain Development and Diseases of Preterm Infants

Respiratory and Gastrointestinal Management of an Infant with a Birth Weight of 258 Grams

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