Neurodevelopmental outcomes in children in relation to placental abruption

Ananth, CV; Friedman, AM; Lavery, Jessica A.; VanderWeele, TJ; Keim, Sarah A.; Ma, Williams

doi:10.1111/1471-0528.14049

Cited by 25 publications

(12 citation statements)

References 42 publications

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“…Finally, there were also long-term risks for the neonate associated with abruption, most of which were likely attributed to the in utero exposure to hypoxia (►Table 5). The most frequently described long-term outcome among surviving neonates was elevated risk of cerebral palsy, 58,[112][113][114][115][116] but there have also been reports of elevated risk of chronic lung disease, 25,71 infant mortality, 48 cognitive deficits, 117 and epilepsy. 118 It is worth noting that the association between abruption and cerebral palsy was not universal.…”

Section: Neonatal Long-term Morbidity and Mortalitymentioning

confidence: 99%

Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review

2017

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Objective Risk factors for placental abruption have changed, but there has not been an updated systematic review investigating outcomes. Methods We searched PubMed, EMBASE, Web of Science, SCOPUS, and CINAHL for publications from January 1, 2005 through December 31, 2016. We reviewed English-language publications reporting estimated incidence and/or risk factors for maternal, labor, delivery, and perinatal outcomes associated with abruption. We excluded case studies, conference abstracts, and studies that lacked a referent/comparison group or did not clearly characterize placental abruption. Results A total of 123 studies were included. Abruption was associated with elevated risk of cesarean delivery, postpartum hemorrhage and transfusion, preterm birth, intrauterine growth restriction or low birth weight, perinatal mortality, and cerebral palsy. Additional maternal outcomes included relaparotomy, hysterectomy, sepsis, amniotic fluid embolism, venous thromboembolism, acute kidney injury, and maternal intensive care unit admission. Additional perinatal outcomes included acidosis, encephalopathy, severe respiratory disorders, necrotizing enterocolitis, acute kidney injury, need for resuscitation, chronic lung disease, infant death, and epilepsy. Conclusion Few studies examined outcomes beyond the initial birth period, but there is evidence that both mother and child are at risk of additional adverse outcomes. There was also considerable variation in, or absence of, the reporting of abruption definitions.

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Section: Neonatal Long-term Morbidity and Mortalitymentioning

confidence: 99%

Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review

2017

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“…7 -13 Adverse outcome related to prematurity and birthrelated asphyxia may compromise neurodevelopmental outcome of these children. 7 Data reveal that children who survive after placental abruption have a higher risk for conditions such as cerebral palsy, [8][9][10] cystic periventricular leukomalacia, intraventricular hemorrhage, 8,11 respiratory distress syndrome (RDS), 13 and neonatal apnea. 12 This may increase the overall mortality.…”

mentioning

confidence: 99%

“…In addition to increased morbidity, the impact of abruption on perinatal mortality has been demonstrated in several studies and populations. 4,5,7,14 Nevertheless, systematic studies on overall and cause-specific mortality of these children do not exist. Our aim was to more thoroughly evaluate the overall and cause-specific mortality of children born after placental abruption.…”

mentioning

confidence: 99%

Placental Abruption and Child Mortality

Riihimäki¹,

Metsäranta

Paavonen³

et al. 2018

Pediatrics

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“…Placental abruption, the premature separation of the placenta prior to delivery, due to a rupture of the decidual vessels and subsequent haematoma formation, is a life‐threatening obstetric emergency; it is not uncommon, occurring approximately once in 100 pregnancies . It is associated with an elevated risk of maternal mortality, as well as perinatal and neonatal mortality and development . Further, as patients who have experienced placental abruption have a higher risk of future cardiovascular mortality and morbidity, it is also a concern from the viewpoint of women’s lifelong health.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Asian dust within a few days of delivery is associated with placental abruption in Japan: a case‐crossover study

Michikawa

Yamazaki

Shimizu

et al. 2019

BJOG

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Objective Asian dust is a natural phenomenon in which dust particles are transported from desert areas in China and Mongolia to East Asia. Short‐term exposure to Asian dust has been associated with cardiovascular disease through mechanisms such as systemic inflammation. Because inflammation is a potential trigger of placental abruption, exposure may also lead to abruption. We examined whether exposure to Asian dust was associated with abruption. Design A bi‐directional, time‐stratified case‐crossover design. Setting and population From the Japan Perinatal Registry Network database, we identified 3014 patients who delivered singleton births in hospitals in nine Japanese prefectures from 2009 to 2014 with a diagnosis of placental abruption. Methods Asian dust levels were measured at Light Detection and Ranging monitoring stations, and these measurements were used to define the Asian dust days. As there was no information on the onset day of abruption, we assumed this day was the day before delivery (lag1). Main outcome measures Placental abruption. Results During the study period, the Asian dust days ranged from 15 to 71 days, depending on the prefecture. The adjusted odds ratio of placental abruption associated with exposure to Asian dust was 1.4 (95% confidence interval = 1.0, 2.0) for cumulative lags of 1–2 days. Even after adjustment for co‐pollutant exposures, this association did not change substantially. Conclusions In this Japanese multi‐area study, exposure to Asian dust was associated with an increased risk of placental abruption. Tweetable abstract Exposure to environmental factors such as Asian dust may be a trigger of placental abruption.

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Neurodevelopmental outcomes in children in relation to placental abruption

Abstract: Increased risk of cognitive deficits in relation to abruption appears to be mediated through preterm delivery.

Cited by 25 publications

References 42 publications

Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review

Maternal, Labor, Delivery, and Perinatal Outcomes Associated with Placental Abruption: A Systematic Review

Placental Abruption and Child Mortality

Exposure to Asian dust within a few days of delivery is associated with placental abruption in Japan: a case‐crossover study

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