Neurodevelopmental outcome of children with congenital hypothyroidism diagnosed in a national screening program in Turkey

Baysal, Bahar Toklu; Baysal, Bora E.; Genel, Ferah; Erdur, Barış; Özbek, Erhan; Demir, Korcan; Özkan, Berna

doi:10.1007/s13312-017-1111-5

Cited by 13 publications

(12 citation statements)

References 9 publications

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“…This was shown in a recent study in 30 such children aged at least 6 years, who demonstrated multiple brain white matter lesions, which correlated with deficits in language development [60]. A study from Turkey showed mild-to-moderate developmental delay at age 2-3 years in early-diagnosed and treated children with congenital hypothyroidism [61]. Ten-year old children with congenital hypothyroidism who were diagnosed via neonatal screening have been shown to be at risk of reduced health-related quality of life (HRQoL), and adverse perception of self-worth, compared with their euthyroid peers [62].…”

Section: Congenital or Overt Hypothyroidismmentioning

confidence: 80%

Levothyroxine in Children

Brenta

2021

70 Years of Levothyroxine

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Thyroid hormones are essential for the development of the central nervous system early in life. Congenital hypothyroidism once caused the devastating cognitive and physical deficits of cretinism, but this condition is now detected routinely at birth using population-wide neonatal screening in most countries. Early and continuous treatment of these children with levothyroxine (LT4), according to age-specific reference ranges, ensures near-normal neuropsychological development, with preserved IQ, although the possibility of subtle residual effects on some indices of neuropsychological functioning remain an active area of research. Children who develop overt hypothyroidism also require treatment with LT4. Most children diagnosed with subclinical hypothyroidism are unlikely to require intervention with LT4, as this condition reverses spontaneously over time. These children should be monitored for possible deterioration of thyroid function in future, especially where thyroid autoimmunity is present.

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Section: Congenital or Overt Hypothyroidismmentioning

confidence: 80%

Levothyroxine in Children

Brenta

2021

70 Years of Levothyroxine

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“…The incidence of congenital hypothyroidism varies from country to country, the low incidence of this pathology in developing countries [12,13] may change with systematic screening. Early detection and management of congenital hypothyroidism may also reduce complications, especially mental and intellectual retardation [14][15][16]. Early treatment should be started during the first two weeks of life to have good results [17].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Biological Characteristics of Congenital Hypothyroidism: A Family Case Study

Mebrouk¹,

Gaouzi²,

Touzani³

et al. 2021

AJPR

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Hypothyroidism is the condition of thyroid hormone deficiency. It can be primary or acquired. Primary hypothyroidism can be congenital or late onset. The symptoms of congenital hypothyroidism may go unnoticed in newborns if undiagnosed. Untreated, hypothyroidism can lead to poor mental and intellectual development in children. Hypothyroidism’s clinical manifestations are often subtle or not present at birth. Common symptoms include decreased activity and increased sleep, feeding difficulty, and constipation. On examination, common signs include myxoedematous facies, large fontanels, macroglossia, a distended abdomen with umbilical hernia, and hypotonia. Levothyroxine is the treatment of choice. In general, the prognosis is excellent when this condition is detected by screening and started on treatment early.

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“…Çok düşük doğum ağırlıklı (ÇDDA<1500 g) bebeklerde tiroksin (T4) düzeyleri yenidoğanın olumsuz sonuçları (ölüm, intraventriküler kanama, periventriküler lökomalazi, serebral palsi) ile ilişkilidir (8). Ayrıca uzun dönemde konjenital hipotiroidinin (KH) nörogelişimsel sonuçlara olumsuz etkisi olduğu bilinmektedir (9,10). Geç prematüre (GH 34-36 hafta arası) bebeklerde hormonları ile solunum desteği arasında ilişki olmadığı rapor edilmiştir.…”

Section: Introductionunclassified

Investigation of The Relationship Between Congenital Hypothyroidism and Respiratory Distress Syndrome in Very Low Birth Weight Newborns

Çakır¹,

Tayman²,

Bekmez³

et al. 2020

atfm

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Objectives: Respiratory distress syndrome (RDS) is associated with severe morbidity and mortality, which occurs due to surfactant deficiency in the lung. In the present study, we aimed to determine the risk factors for RDS and the effect of congenital hypothyroidism (CH) on RDS in very low birth weight (VLBW<1500 g) infants. Materials and Methods: The study was completed between January 2013 and August 2017. Data of eligible infants were obtained from hospital medical records. Patients were divided in to groups with and without CH, and those with and without RDS according to requirement of surfactant therapy. Results: Six hundred and seventy patients of 729 patients (gestational age: 27.5±1.3 weeks, birth weight: 1014±219 g) were included in the study, and thyroid function test results were obtained on day 5 th respiratory distress syndrome ratio was 71.4% (n=20) in the CH group (n=28) and 61.3% (n=394) in the non-CH group (n=642). Respiratory distress syndrome ratio (71.4%) was found to be statistically higher in CH group than those in non-CH group (61.3%) (p=0.000). The frequency of CH (5.3% vs 2.3%, p=0.015, respectively) was higher in patients with RDS. RDS ratio in those with CH and CHD in those with RDS were found to be higher. Conclusion: Based on these findings, it is thought that thyroid hormones may affect lung development and dynamics.

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Neurodevelopmental outcome of children with congenital hypothyroidism diagnosed in a national screening program in Turkey

Abstract: Some children with congenital hypothyrodism may have mild to moderate neurodevelopmental retardation, despite the early diagnosis and treatment, and thus need to be under regular follow-up for neurodevelopmental status.

Cited by 13 publications

References 9 publications

Levothyroxine in Children

Levothyroxine in Children

Clinical and Biological Characteristics of Congenital Hypothyroidism: A Family Case Study

Investigation of The Relationship Between Congenital Hypothyroidism and Respiratory Distress Syndrome in Very Low Birth Weight Newborns

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