Neurodevelopmental Outcome at 2 Years for Preterm Children Born at 22 to 34 Weeks’ Gestation in France in 2011: EPIPAGE-2 Cohort Study

Abstract

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Strategies for assessing the impact of loss to follow-up on estimates of neurodevelopmental impairment in a very preterm cohort at 2 years of age

“…Our results on the factors associated with loss to follow-up are consistent with studies on very preterm birth [5,6,7,39,40] and other cohorts [8,9,41,42] which find that non-responders have lower socioeconomic status, as measured by maternal education, social deprivation scores, migrant status and young maternal age. These studies also report differences in exposures associated with socioeconomic status, such as breastfeeding and tobacco use [7,12,40]. These factors, in particular, maternal age, migration, maternal education and breastfeeding have all been associated with neurodevelopmental outcomes after VPT birth [43,44].…”

“…It is difficult to compare our results to the literature because this bias is rarely quantified. In the French Epipage 2 study of very preterm births < 32 weeks of gestation, MI was used to adjust for non-response at two-years; these adjustments were generally concordant with ours: estimates of cerebral palsy prevalence rose from 4.6 to 4.8% (4% increase) and, among children without severe motor impairments, the percentage with Ages and Stages Questionnaire (ASQ) scores below the screening threshold increased from 42.0 to 47.8% (a 14% increase) [40]. The larger adjustment for the neurodevelopmental measure, compared to cerebral palsy, may reflect the stronger impact of social factors on neurodevelopment than on severe gross motor impairment [45,46].…”

“…In our sample, the response rate was 54.2% which is at the lower end reported in other very preterm cohorts in early childhood which range from about 50 to 90% [6,7,12,38,39,40]. Follow-up rates tend to be higher for studies from neonatal networks when compared to population-based studies and those that have regular contact with families after discharge.…”

Developmental cascades of social inhibition and friendships in preterm and full‐term children

“…The sample was recruited between 1985 and 1986, and thus replications with more recent samples are necessary, given that with improvements in neonatal care, survival of preterm infants has substantially improved over the past decades. Nevertheless, in general, the long-term neurodevelopmental outcomes after preterm birth appear to be comparable, even in more recent samples (Cheong et al, 2017;Pierrat et al, 2017;. Despite the exceptionally good fit of the data to the model in the current study, it only explained a small amount of variance.…”

Profile of at-risk newborns attended by nurses in outpatient follow-up clinic: a retrospective cohort study

“…Regarding the data on GA and birth weight present in Table 1, this study found that the lower the gestational age and the birth weight, the more frequent and the greater the follow-up visits are. Some researches show this need for more frequent follow-up when they affirm that low birth weight and prematurity are related to an increase in morbidity and mortality, chronic conditions and readmissions 2 - 3 , 9 , 19 , 27 - 31 , as well as to the greater risk of growth deficit 3 , 21 , developmental delays and cognitive and behavioral problems 3 , 7 , 31 - 32 . In addition, growth must be closely monitored in the first year of life of patients with this profile, thus ensuring optimal brain nutrition and reducing risks of neurodevelopmental delays 19 , 33 .…”