Neurodevelopmental markers in different psychopathological dimensions of first episode psychosis: The ESPIGAS Study

Ruiz‐Veguilla, Miguel; Cervilla, Jorge A.; Barrigón, María Luisa; Ferrín, Maite; Gutiérrez, Blanca; Gordo, E.; Anguita, M.A. Martinez; Brañas, Antía; Fernández-Logroño, Jesús; Gurpegui, Manuel

doi:10.1016/j.eurpsy.2008.04.003

Cited by 22 publications

(10 citation statements)

References 40 publications

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“…First, the statistical methods used to perform the analyses did not take into account the nonresponse error stemming from missing observations, which may render the findings less conclusive. Second, we did not statistically control for other factors known to be associated with the severity of symptoms such as socioeconomic status, 5 neurodevelopmental markers, 16 and obstetric complications. 16 Factors that were statistically controlled in this study may not be reflective of the actual constructs that we had aimed to measure; instead of using only academic achievement as a proxy measure for premorbid functioning, incorporating social functioning might have increased the validity of the measurement.…”

Section: Discussionmentioning

confidence: 99%

Cross‐ethnic differences in severity of symptomatology of individuals with first‐episode schizophrenia spectrum disorder

Lim

Subramaniam²,

Poon

et al. 2011

Early Intervention Psych

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Section: Discussionmentioning

confidence: 99%

Cross‐ethnic differences in severity of symptomatology of individuals with first‐episode schizophrenia spectrum disorder

Lim

Subramaniam²,

Poon

et al. 2011

Early Intervention Psych

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“…In terms of clinical correlates, poor premorbid social functioning has been specifically associated with symptom-related variables, particularly acute and persistent negative symptoms, and longer duration of untreated psychosis (Allen et al, 2001; McClellan et al, 2003; Larsen et al, 2004; Jeppesen et al, 2008; Ruiz-Veguilla et al, 2008; Strauss et al, 2012; Chang et al, 2013), whereas poor premorbid academic functioning has been specifically associated with greater neurocognitive and intellectual impairment, and earlier onset of prodromal symptoms (Allen et al, 2001; Larsen et al, 2004; Norman, Malla, Manchanda, and Townsend, 2005; Rund et al, 2007). In terms of differential trajectories of academic and social premorbid functioning across development, there is some evidence that premorbid academic functioning deteriorates more steeply from childhood across adolescence, compared to a more stable course of social premorbid adjustment (Monte, Goulding, and Compton, 2008; Barajas et al, 2013).…”

Section: ) Introductionmentioning

confidence: 99%

Trajectories of premorbid childhood and adolescent functioning in schizophrenia-spectrum psychoses: A first-episode study

Horton¹,

Tarbox²,

Olino³

et al. 2015

Psychiatry Research

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Evidence of social and behavioral problems preceding the onset of schizophrenia-spectrum psychoses is consistent with a neurodevelopmental model of these disorders. Here we predict that individuals with a first episode of schizophrenia-spectrum psychoses will evidence one of three patterns of premorbid adjustment: an early deficit, a deteriorating pattern, or adequate or good social adjustment. Participants were 164 (38% female; 31% black) individuals ages 15–50 with a first episode of schizophrenia-spectrum psychoses. Premorbid adjustment was assessed using the Cannon-Spoor Premorbid Adjustment Scale. We compared the fit of a series of growth mixture models to examine premorbid adjustment trajectories, and found the following 3-class model provided the best fit with: a “stable-poor” adjustment class (54%), a “stable-good” adjustment class (39%), and a “deteriorating” adjustment class (7%). Relative to the “stable-good” class, the “stable-poor” class experienced worse negative symptoms at 1-year follow-up, particularly in the social amotivation domain. This represents the first known growth mixture modeling study to examine premorbid functioning patterns in first-episode schizophrenia-spectrum psychoses. Given that the stable-poor adjustment pattern was most prevalent, detection of social and academic maladjustment as early as childhood may help identify people at increased risk for schizophrenia-spectrum psychoses, potentially increasing feasibility of early interventions.

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“…17,33 Whilst reported results have at times been conflicting, the association between NSS and negative symptoms seems particularly robust. 13,[19][20][21][22][23][24][25] However, this association has not been confirmed by all studies. [34][35][36] Rather the link seems to be more clear in samples with a severe or chronic illness outcome eg persistence of negative symptoms in spite of adequate antipsychotic treatment.…”

Section: Discussionmentioning

confidence: 66%

Neurological soft signs as an endophenotype in an African schizophrenia population – a pilot study

Smit¹,

Koen²,

Niehaus³

et al. 2012

Afr. J. Psych

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Objective: The use of endophenotypes, such as neurological soft signs (NSS), is advocated as one possible method to elucidate the heterogeneity of schizophrenia. Exploring the associations between NSS and specific illness symptoms has revealed some trends, although results have been conflicting. To date, such studies have been conducted largely on Caucasian populations and our pilot study represents the first attempt to gather such data in a homogenous African population. Method: Fifty-one patients, all of Xhosa ethnicity and participating in a larger schizophrenia genetic study were recruited. NSS were evaluated using a modified Neurological Evaluation Scale. Data were analysed using SPSS with the strength of the overall relationships between NES groups and SANS and SAPS components analyzed by means of canonical correlation analysis. Results: The canonical correlation of SANS domains (excluding asociality) with the NES conceptual groups was 0.53 (SE=0.11, p=0.024) and of the SAPS domains 0.38 (SE=0.13, p=0.943). Conclusion: Our results suggest a correlation between negative symptoms of schizophrenia and the presence of NSS, supporting the recruitment of a larger sample to more comprehensively evaluate a possible role for NSS as an endophenotype in the Xhosa schizophrenia population. Taking into account that NSS evaluations allow for inexpensive, relatively easy-to-do objective evaluations, this method presents us with a valuable research tool that can be used effectively within our under-resourced environment to help inform on the neurobiological substrate of schizophrenia.

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Neurodevelopmental markers in different psychopathological dimensions of first episode psychosis: The ESPIGAS Study

Abstract: Our results support that, among non-affective first onset psychotic patients, those with predominant negative symptoms are more likely to correlate with higher presence of neurodevelopmental markers.

Cited by 22 publications

References 40 publications

Cross‐ethnic differences in severity of symptomatology of individuals with first‐episode schizophrenia spectrum disorder

Cross‐ethnic differences in severity of symptomatology of individuals with first‐episode schizophrenia spectrum disorder

Trajectories of premorbid childhood and adolescent functioning in schizophrenia-spectrum psychoses: A first-episode study

Neurological soft signs as an endophenotype in an African schizophrenia population – a pilot study

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