Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis

García-Serna, Azahara M; Morales, Eva

doi:10.1038/s41380-019-0357-9

Cited by 82 publications

(91 citation statements)

References 54 publications

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“…Meta-analysis of eight studies found that an increase in autism-related traits and diagnosed ASD was correlated with decreased maternal serum vitamin D concentrations. Reductions in cognitive ability were most associated with low concentration in early-mid pregnancy [ 73 ]. This association appears to weaken later in pregnancy; a cohort of 4229 Dutch mother–child pairs found that low vitamin D status at mid-gestation and at delivery was associated with ASD symptoms but low vitamin D at delivery alone was not [ 74 ].…”

Section: Vitamin D/vitamin D Receptor Signalling In Neurodevelopmentamentioning

confidence: 99%

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

2020

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The gut microbiome regulates a relationship with the brain known as the gut–microbiota–brain (GMB) axis. This interaction is influenced by immune cells, microbial metabolites and neurotransmitters. Recent findings show gut dysbiosis is prevalent in autism spectrum disorder (ASD) as well as attention deficit hyperactivity disorder (ADHD). There are previously established negative correlations among vitamin D, vitamin D receptor (VDR) levels and severity of ASD as well as ADHD. Both vitamin D and VDR are known to regulate homeostasis in the brain and the intestinal microbiome. This review summarizes the growing relationship between vitamin D/VDR signalling and the GMB axis in ASD and ADHD. We focus on current publications and summarize the progress of GMB in neurodevelopmental disorders, describe effects and mechanisms of vitamin D/VDR in regulating the microbiome and synoptically highlight the potential applications of targeting vitamin D/VDR signalling in neurodevelopment disorders.

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Section: Vitamin D/vitamin D Receptor Signalling In Neurodevelopmentamentioning

confidence: 99%

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

2020

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“…The effects may vary in different cells and under different conditions. Studies examining vitamin D‐dependent responses have, in some cases, indicated a protective role and, in others, a stimulation of apoptosis . However, the reported suppression on proliferation and survival in many cell types has led to an interest in vitamin D administration as a possible treatment to counteract tumour growth or reduce cancer risk …”

Section: Vitamin D and Inhibition Of Cellular Proliferation: A Role Imentioning

confidence: 99%

“…For example, developmental vitamin D deficiency in animals has been linked to phenotypes of relevance for autism . In humans, prenatal exposure to 25‐hydroxyvitamin D 3 has been associated with improved cognitive development and a reduced risk of attention deficit hyperactivity disorder and autism‐related traits later in life . Vitamin D deficiency has also been proposed as an environmental risk factor for schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Effects of vitamin D in the nervous system: Special focus on interaction with steroid hormone signalling and a possible role in the treatment of brain cancer

Norlin

2019

J Neuroendocrinology

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The active vitamin D hormone, 1,25-dihydroxyvitamin D 3 , exerts many physiological actions in the body, including effects on the nervous system. Studies of steroidogenesis in cells of the nervous system and elsewhere not only indicate that 1,25-dihydroxyvitamin D 3 affects steroidogenic pathways but also suggest varying responses in different cell types. For example, 1,25-dihydroxyvitamin D 3 stimulates the expression of aromatase in human glioma but not in human neuroblastoma cells or rat astrocytes. However, in astrocytes, 1,25-dihydroxyvitamin D 3 suppresses 3β-hydroxysteroid dehydrogenase and steroid 17-hydroxylase/lyase. Other studies indicate cross-talk between vitamin D signalling and signalling of oestrogens, progesterone or glucocorticoids. Reported data indicate synergistic effects of combinations of 1,25-dihydroxyvitamin D 3 and other steroid hormones on neuroinflammation, neurite outgrowth and neuroprotection. Also, dysregulation of steroid pathways affecting brain cells is found in vitamin D deficiency. Thus, several studies suggest that active vitamin D may affect steroid hormone synthesis and/or signalling in the nervous system, although the potential mechanisms for these responses remain unclear.1,25-Dihydroxyvitamin D 3 suppresses proliferation in several cell types and is therefore of interest in cancer treatment. Also, epidemiological studies associate vitamin D levels with cancer risk or outcomes. Reported data on tumours of the nervous system are mainly on glioma, a common type of brain cancer. Expression of the vitamin D receptor in glioma tumours is associated with improved survival. Several studies show that 1,25-dihydroxyvitamin D 3 and vitamin D analogues (synthetic vitamin D-like compounds) suppress proliferation and migration in human vitamin D receptor-expressing glioma cell lines. Studies on mechanisms for actions of 1,25-dihydroxyvitamin D 3 or its analogues indicate regulation of cell cycle proteins and senescence markers. These compounds also show synergism in combination with other cancer therapies treating glioma. From the data available, vitamin D analogues emerge as interesting candidates for the future improved treatment of human glioma and possibly also other cancers of the nervous system. K E Y W O R D Sglioblastoma, growth, steroid hormone, steroidogenesis, vitamin D

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“…This could be why low levels of this vitamin during this period may be closely related to the children’s neurodevelopment [ 30 , 31 ] and why this effect on cognitive and language skills is not observed when the vitamin D deficiency occurs at the end of gestation. In our study we assessed the effect on neurodevelopment at 40 days, as other authors have [ 13 , 15 ]. However, more follow-up studies are needed on the long-term effects (i.e., during childhood and adolescence) of low levels of vitamin D during the first trimester.…”

Section: Discussionmentioning

confidence: 99%

“…Darling et al [ 14 ] suggested that, as well as motor skills, deficient prenatal vitamin D status may also have adverse effects on certain social development measures in children under four. Similarly, a metanalysis of 25 epidemiological studies supported evidence that high 25-hydroxyvitamin D3 (25(OH)D3) levels (a pheromone produced in the liver by the hydroxylation of vitamin D3 (cholecalciferol)) were associated with improved cognitive development and lower risks of attention deficit hyperactivity disorder and autism-related traits later in life [ 15 ]. In a Spanish population-based cohort study (INMA Project) conducted with 1820 mother–infant pairs, infants of mothers with higher circulating concentrations of 25(OH)D3 between the end of the first trimester and the beginning of the second trimester of pregnancy (>75 nmol/L) showed higher mental and psychomotor scores than those of mothers with lower concentrations (<50 nmol/L) [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study

et al. 2020

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Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother–infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded. Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (<30 nmol/L) predicted a worse performance in cognitive and language skills. Language performance worsened with lower vitamin D levels (<20 nmol/L). In the third trimester, this highly deficient level was also associated with lower motor skills. Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment.

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Neurodevelopmental effects of prenatal vitamin D in humans: systematic review and meta-analysis

Cited by 82 publications

References 54 publications

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

Gut instincts: vitamin D/vitamin D receptor and microbiome in neurodevelopment disorders

Effects of vitamin D in the nervous system: Special focus on interaction with steroid hormone signalling and a possible role in the treatment of brain cancer

Effect of Vitamin D Status during Pregnancy on Infant Neurodevelopment: The ECLIPSES Study

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