Neurodevelopmental effects of childhood malnutrition: A neuroimaging perspective

Galler, Janina R.; Bringas‐Vega, Maria L.; Tang, Qin; Rabinowitz, Arielle G.; Musa, Kamarul Imran; Chai, Wen Jia; Omar, Hazim; Rahman, Muhammad Riddha Abdul; Hamid, Aini Ismafairus Abd; Abdullah, Jafri Malin; Valdés‐Sosa, Pedro A.

doi:10.1016/j.neuroimage.2021.117828

Cited by 53 publications

(46 citation statements)

References 94 publications

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“…The situation will likely be exacerbated by the COVID-19 pandemic according to UNICEF (2021) due to deteriorations in household wealth and disruptions to the availability and affordability of nutritious food and essential nutrition services. Protein-energy malnutrition (PEM) or severe acute malnutrition (SAM) is a specific type of malnutrition defined as an acute caloric deficit due to deficiency of all macronutrients, and micronutrients in some cases (see Galler et al, 2021 for a review of the definitions).…”

Section: Introductionmentioning

confidence: 99%

Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study

Roger

Vannasing

Tremblay

et al. 2022

Front. Hum. Neurosci.

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More than 200 million children under the age of 5 years are affected by malnutrition worldwide according to the World Health Organization. The Barbados Nutrition Study (BNS) is a 55-year longitudinal study on a Barbadian cohort with histories of moderate to severe protein-energy malnutrition (PEM) limited to the first year of life and a healthy comparison group. Using quantitative electroencephalography (EEG), differences in brain function during childhood (lower alpha1 activity and higher theta, alpha2 and beta activity) have previously been highlighted between participants who suffered from early PEM and controls. In order to determine whether similar differences persisted into adulthood, our current study used recordings obtained during a Go-No-Go task in a subsample of the original BNS cohort [population size (N) = 53] at ages 45–51 years. We found that previously malnourished adults [sample size (n) = 24] had a higher rate of omission errors on the task relative to controls (n = 29). Evoked-Related Potentials (ERP) were significantly different in participants with histories of early PEM, who presented with lower N2 amplitudes. These findings are typically associated with impaired conflict monitoring and/or attention deficits and may therefore be linked to the attentional and executive function deficits that have been previously reported in this cohort in childhood and again in middle adulthood.

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Section: Introductionmentioning

confidence: 99%

Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study

Roger

Vannasing

Tremblay

et al. 2022

Front. Hum. Neurosci.

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“…The results presented in this paper contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings, especially those in low resource areas that are at greatest risk for neurodevelopmental disabilities and other brain disorders (Galler et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Harmonized-Multinational qEEG Norms (HarMNqEEG)

Wang

Lopez-Naranjo

et al. 2022

Preprint

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This paper extends our frequency domain quantitative electroencephalography (qEEG) methods pursuing higher sensitivity to detect Brain Developmental Disorders. Prior qEEG work lacked integration of cross-spectral information omitting important functional connectivity descriptors. Lack of geographical diversity precluded accounting for site-specific variance, increasing qEEG nuisance variance. We ameliorate these weaknesses. i) Create lifespan Hermitian Riemannian multinational qEEG norms for cross-spectral tensors. These norms result from the HarMNqEEG project fostered by the Global Brain Consortium. We calculate the norms with data from 9 countries, 12 devices, and 14 studies, including 1564 subjects. Instead of raw data, only anonymized metadata and EEG cross-spectral tensors were shared. After visual and automatic quality control developmental equations for the mean and standard deviation of qEEG traditional and Hermitian Riemannian descriptive parameters were calculated using additive mixed-effects models. We demonstrate qEEG "batch effects" and provide methods to calculate harmonized z-scores. ii) We also show that the multinational harmonized Hermitian Riemannian norms produce z-scores with increased diagnostic accuracy to predict brain dysfunction at school-age produced by malnutrition only in the first year of life. We provide data and software for constructing norms. iii) We offer open code and data to calculate different individual z-scores from the HarMNqEEG dataset. These results contribute to developing bias-free, low-cost neuroimaging technologies applicable in various health settings.

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“…This demonstrated that untreated malnutrition worsens the children's quality of life. 27 Considering the burden severity of malnutrition in children in cancer, malnutrition in children with cancer should be well screened. Before using any specific screening tools, history taking is critical as an initial step.…”

Section: Risk Factors Of Malnutrition In Children With Cancermentioning

confidence: 99%

Disease-related malnutrition in children with cancer: What’s the risk and the impact on patient's outcome?

Sudarmanto

Primavita

2022

World Nutr J

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Background: Malnutrition in children with cancer is a common problem, particularly in low-income countries. Risk factors, effects on outcome, and feasible interventions are important to comprehend in managing patients. Objectives: To know the risk and impact of malnutrition in children with patients. Discusion: Children with cancer are at risk of suffering from malnutrition. Malnutrition occurs due to energy imbalance and results from multifactorial interactions, including type of tumors and therapy. Malnutrition can contribute to poor clinical outcome and decreased quality of life. Management of malnutrition in pediatric patients with cancer include screening and nutritional interventions with suitable route of administration based on patient condition.

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Neurodevelopmental effects of childhood malnutrition: A neuroimaging perspective

Cited by 53 publications

References 94 publications

Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study

Impact of Early Childhood Malnutrition on Adult Brain Function: An Evoked-Related Potentials Study

Harmonized-Multinational qEEG Norms (HarMNqEEG)

Disease-related malnutrition in children with cancer: What’s the risk and the impact on patient's outcome?

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