Neurodevelopmental disorders in children and the possibilities of their pharmacotherapy

Zavadenko, N. N.; Suvorinova, N. Yu.; Zavadenko, A. N.; Fateeva, V V

doi:10.17116/jnevro202112111238

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…В классификации DSM-5 и МКБ-11 «Расстройства нервно-психического развития (РНПР)» введены в качестве всеохватывающей категории заболеваний, характеризующихся нарушениями формирования когнитивных функций, навыков общения, характеристик поведения и / или двигательных навыков. Они включают: общую интеллектуальную недостаточность (расстройство развития интеллекта), коммуникативные расстройства (нарушения развития речи), расстройства аутистического спектра, синдром дефицита внимания и гиперактивности (СДВГ), специфические расстройства обучения, расстройства развития двигательной сферы [3].…”

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Inter-cohort analysis of parental risk factors for development of infants

Shmatova¹,

Razvarina²,

Gordievskaya³

2023

Health Risk Analysis

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Children develop rapidly in the first year of life and this period should create a solid ground for their health in future. Diseases of the nervous system, mental and behavioral disorders occupy leading places among causes of childhood disability. Given that, the aim of this study was to search for parental risk factors endangering physical and neuropsychic development of infants. Infants living in Vologda region were selected as a research object. Our informational basis was represented by sample data of the prospective monitoring over children’s health (894 children from five different cohorts born in 1998, 2001, 2004, 2014 and 2020); statistical and sociological data on prevalence of risk factors in Russia and in the region. The information was provided by healthcare workers (obstetrician-gynecologist, neonatologist, and pediatrician) and children’s mothers. The applied methodology included inter- and intra-cohort sociological analysis; calculation of relative risk (RR) to assess a correlation between developmental delay and parental factors. Child development was assessed by a pediatrician using abnormal psychology and adaptation approaches. We analyzed Russian and foreign studies that focused on the same research subject. We calculated relative risks of various social-demographic, socioeconomic, biomedical and environmental factors for the development of children who participated in the cohort monitoring. This allowed us to identify those with prognostic value including young age of parents (RR = 1.40); a single-parent family (RR = 1.46), bad relationships between spouses (RR = 1.36); low purchasing ability of a family (RR = 1.59), poor living conditions (RR = 1.66); a future mother being exposed to chemicals and toxic substances (RR = 1.31), gas pollution (RR = 2.02), hand high temperatures (RR = 1.56) at her workplace one year prior to childbirth; a smoking mother (RR = 1.56); a father having a sexually transmitted disease (RR = 3.23); abnormal pregnancy. The identified risk factors for child development occur prior to childbirth and are manageable. Awareness about them makes it possible to neutralize their negative influence when a pregnancy is being planned. Our analysis of statistical and sociological data has revealed a descending trend for prevalence of practically all the analyzed risk factors. Still, some factors cause certain concern including high prevalence of smoking among women, future mothers included; prevalence of anemia in pregnant women; unresolved financial issues and poor living conditions of a considerable share of families who are expecting a child; effects produced on women by harmful working conditions. The results of this study can be used for developing programs aimed at protecting child’s health at any level, from an individual to the national one.

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Inter-cohort analysis of parental risk factors for development of infants

Shmatova¹,

Razvarina²,

Gordievskaya³

2023

Health Risk Analysis

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Home reading environment, sociometric and demographic factors associated with dyslexia in primary school students in China: A case-control study

Zou,

Huang,

et al. 2023

Heliyon

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Efficacy and safety of a daytime anxiolytic containing technologically processed antibodies to the S100 protein. Overview of clinical studies

Perez

Zavadenko

Skipetrova

et al. 2023

RJTAO

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The review presents the results of clinical studies of the efficacy and safety of Tenoten and Tenoten children’s in the treatment of anxiety, neurotic, stress-related and somatoform disorders and adjustment disorders. Technologically processed antibodies to the S100 protein in Tenoten and Tenoten children’s drugs change the conformation of the S100 protein, which is considered as a pathological link in the development of anxiety states, as well as neurodegenerative diseases. Tenoten is a well-studied daytime anxiolytic that combines a favorable safety profile with high anxiolytic activity. The efficacy of Tenoten in the treatment of anxiety disorders is comparable to that of benzodiazepine drugs. Tenoten has no inhibitory and muscle relaxant effects, does not cause drug tolerance, addiction, "withdrawal" syndrome, as well as drug interactions. Tenoten for children has been shown to be effective in the treatment of anxiety in children, including those with somatic manifestations, attention deficit hyperactivity disorder, and learning disabilities.

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Neurodevelopmental disorders in children and the possibilities of their pharmacotherapy

Cited by 4 publications

References 29 publications

Inter-cohort analysis of parental risk factors for development of infants

Inter-cohort analysis of parental risk factors for development of infants

Home reading environment, sociometric and demographic factors associated with dyslexia in primary school students in China: A case-control study

Efficacy and safety of a daytime anxiolytic containing technologically processed antibodies to the S100 protein. Overview of clinical studies

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