Neurodevelopmental disorders and incontinence in children and adolescents: Attention‐deficit/hyperactivity disorder, autism spectrum disorder, and intellectual disability—A consensus document of the International Children's Continence Society

Gontard, Alexander von; Hussong, Justine; Yang, Stephen Shei‐Dei; Chase, Janet; Franco, Israel; Wright, Anne

doi:10.1002/nau.24798

Cited by 22 publications

(9 citation statements)

References 51 publications

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“…The presence of ADHD has a negative influence on incontinence treatment: The compliance in children with ADHD is much lower and treatment outcomes are worse. Specific brain regions such as the anterior cingulate gyrus and the dorsal anterior midcingulate cortex are involved in both ADHD and incontinence 19 . In the current report, 72.0% of cases with NDD showed favorable outcomes after 6 months of treatment, and no difference in treatment outcomes was seen compared to cases without NDD.…”

Section: Discussionsupporting

confidence: 38%

“…Specific brain regions such as the anterior cingulate gyrus and the dorsal anterior midcingulate cortex are involved in both ADHD and incontinence. 19 In the current report, 72.0% of cases with NDD showed favorable outcomes after 6 months of treatment, and no difference in treatment outcomes was seen compared to cases without NDD. Clinically, our results suggest that vibegron may represent an effective treatment for refractory DUI in the future.…”

Section: Discussionmentioning

confidence: 41%

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Vibegron shows high efficacy in pediatric patients with refractory daytime urinary incontinence

Hyuga

Tanabe

Kubo

et al. 2023

Neurourology and Urodynamics

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Purpose: Sparse published reports exist nowadays on vibegron and pediatric overactive bladder, so its usefulness of this agent remains unclear. The purpose of this study was to clarify the effectiveness of vibegron for pediatric cases of daytime urinary incontinence (DUI), including refractory cases.Methods: Participants comprised 57 patients treated with vibegron for DUI from March 2019 to April 2022. To investigate treatment outcomes and risk factors for pediatric patients with refractory DUI, the following factors were evaluated: age at initiatial administration; frequency of DUI; duration of vibegron treatment; presence of neurodevelopmental disorders (NDDs); presence of constipation; and anticholinergic medications before and after initiation of treatment.Results: Patients included 38 boys and 19 girls with a median age at initial administration of 111 months (range: 64-202 months) and a median administration term of 6 months (range: 1-33 months). With treatment for 6 months, the response rate (complete response + partial response) was 68.3%.A total of 24 cases with NDD showed a 72.0% response rate at 6 months. As for the relationship between anticholinergic agents and vibegron, 15 cases were treated with vibegron as the first choice without anticholinergics (First-choice cases), and 33 cases were treated with vibegron alone after switching from anticholinergics (Switch cases). Vibegron was used in combination with anticholinergic agents in 9 cases (Add-on cases). Response rates at 6 months were 85.0% in First-choice cases, 66.3% in Switch cases, and 40.7% in Add-on cases. Univariate analyses failed to identify any significant risk factors for refractory cases. Conclusions: Vibegron was effective in pediatric cases of DUI, with efficacy demonstrated within a short time in many cases. Vibegron is expected to play a significant role in the treatment of DUI in pediatric cases.

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Section: Discussionsupporting

confidence: 38%

Section: Discussionmentioning

confidence: 41%

Vibegron shows high efficacy in pediatric patients with refractory daytime urinary incontinence

Hyuga

Tanabe

Kubo

et al. 2023

Neurourology and Urodynamics

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“…Many neurodivergent individuals also have diagnoses of other disabilities and have to grapple with additional accessibility challenges and ableism (Mannion & Leader, 2013, Tye et al, 2019. Research suggests that a small number of physicalrelated health conditions are prevalent in neurodivergent conditions, including asthma, daytime urinary incontinence, epilepsy, faecal incontinence, gastrointestinal issues, allergies and sleep disorders (e.g., Ajdacic-Gross et al, 2020;Cashin et al, 2018;von Gontard et al, 2021). To date, research regarding co-occurrence and neurodivergent individuals has focused on describing the overlap of a specific neurodivergent condition with other medical conditions, with findings suggesting that on average, neurodivergent individuals have other conditions that are ignored or rarely acknowledged (Bishop-Fitzpatrick & Rubenstein, 2019;Elsherif et al, 2021), leading to less discussion of how best to provide reasonable adjustments that can support the individual and make them feel included and belonged in a specific environment.…”

Section: Intersection Of Neurodivergence and Co-occurring Disabilitiesmentioning

confidence: 99%

Bridging Neurodiversity and Open Scholarship: How Shared Values Can Guide Best Practices for Research Integrity, Social Justice, and Principled Education

Elsherif¹,

Middleton²,

Phan³

et al. 2022

Preprint

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Not all people conform to what is socially construed as the norm and divergences should be expected. Neurodiversity is fundamental to the understanding of human behaviour and cognition. However, neurodivergent individuals are often stigmatised, devalued, and objectified. This position statement presents the perspectives of neurodivergent authors, the majority of whom have personal lived experiences of neurodivergence(s), and discusses how research and academia can and should be improved in terms of research integrity, inclusivity and diversity. The authors describe future directions that relate to lived experience and systematic barriers, disclosure, directions on prevalence, stigma, intersection of neurodiversity and open scholarship, and provide recommendations that can lead to personal and systematic changes to improve acceptance of neurodivergent individuals’ lived experiences within academia.

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“…We did not find a higher prevalence of ADHD or ASD in children with NE despite these conditions being known to coexist with NE. 11 It is possible that the reasons for the low comorbidity of NE and neurodevelopmental disorders in this survey included difficulty in diagnosing ADHD/ASD by primary care physicians and confusion due to multiple diagnostic criteria. For these reasons, we assumed that participants may not have been informed about comorbidities and their answers to these questions may have reflected this lack of understanding.…”

Section: Discussionmentioning

confidence: 98%

Comparison of the characteristics and factors influencing hospital visits among children with nocturnal enuresis in Japan: The Hirakata–Urayasu population‐based cohort study

et al. 2023

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Objectives The aim of this study was to compare the demographic characteristics of school‐aged children with nocturnal enuresis and factors influencing hospital visits between two regions in Japan. Methods A cross‐sectional survey was conducted in Hirakata City, Osaka Prefecture, and Urayasu City, Chiba Prefecture. An anonymous online questionnaire was administered to all public elementary and junior high school students (aged 6–16 years) or their guardians. Questions included age, gender, perinatal history, frequency of nocturnal enuresis, frequency of bowel movements, comorbidities, and hospital visits for nocturnal enuresis. Results The survey response rates were 15.4% in Hirakata City and 37.0% in Urayasu City. In total, 426 children with nocturnal enuresis in Hirakata City and 270 in Urayasu City were included in the final analysis. In both cities, the boy–girl ratio was approximately 2:1, and the prevalence of nocturnal enuresis gradually decreased with age. Multivariate analysis revealed that children aged ≥11 years had a significantly higher proportion of hospital visits (OR, 2.61; 95% CI: 1.49–4.56; p = 0.001; OR, 2.72; 95% CI: 1.12–6.64; p = 0.027, respectively). However, the frequency of nocturnal enuresis did not affect hospital visits. Conclusions The findings of this study suggest that parents with school‐aged children have low awareness that nocturnal enuresis is a health problem and therefore subject to medical consultation. Although the proportion of hospital visits increases for children aged ≥11 years, children and families suffering from nocturnal enuresis should be encouraged to see a doctor instead of adopting a “wait and see attitude,” even at a young age.

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Neurodevelopmental disorders and incontinence in children and adolescents: Attention‐deficit/hyperactivity disorder, autism spectrum disorder, and intellectual disability—A consensus document of the International Children's Continence Society

Cited by 22 publications

References 51 publications

Vibegron shows high efficacy in pediatric patients with refractory daytime urinary incontinence

Vibegron shows high efficacy in pediatric patients with refractory daytime urinary incontinence

Bridging Neurodiversity and Open Scholarship: How Shared Values Can Guide Best Practices for Research Integrity, Social Justice, and Principled Education

Comparison of the characteristics and factors influencing hospital visits among children with nocturnal enuresis in Japan: The Hirakata–Urayasu population‐based cohort study

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