Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study

Larroque, Béatrice; Ancel, Pierre‐Yves; Marret, Stéphane; Marchand, Laëtitia; André, M; Arnaud, Catherine; Pierrat, Véronique; Rozé, Jean‐Christophe; Messer, J; Thiriez, Gérard; Burguet, A.; Picaud, Jean‐Charles; Breart, Gérard; Kaminski, Monique

doi:10.1016/s0140-6736(08)60380-3

Cited by 790 publications

(560 citation statements)

References 35 publications

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“…Although perinatal mortality has decreased over the past 20 y, the incidence of CP has not (1). For instance, a recent population-based prospective study showed that a large proportion of premature newborns under 33 wk of gestation suffer neurologic disabilities, including CP and/or mental deficiency, at 5 y of age (3). Maternal infection/inflammation is one of the main independent risk factors for perinatal brain lesions, both in premature and term newborns (4)(5)(6), and also increases the risk of fetal death and premature delivery.…”

Section: Il-1 Receptor Antagonist Protects Against Placental and Neurmentioning

confidence: 99%

IL-1 Receptor Antagonist Protects against Placental and Neurodevelopmental Defects Induced by Maternal Inflammation

Girard

Tremblay

Lepage

et al. 2010

The Journal of Immunology

194

177

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Section: Il-1 Receptor Antagonist Protects Against Placental and Neurmentioning

confidence: 99%

IL-1 Receptor Antagonist Protects against Placental and Neurodevelopmental Defects Induced by Maternal Inflammation

Girard

Tremblay

Lepage

et al. 2010

The Journal of Immunology

194

177

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show abstract

“…[2][3][4] The utility of predictive assessment tools in young infants is limited by the need for expensive equipment and highly experienced personnel, as well as low accuracy. Although the primary insult(s) cannot be repaired, early identification of CP enables intervention to be instituted while the plasticity of the nervous system is high.…”

mentioning

confidence: 99%

Early prediction of cerebral palsy by computer‐based video analysis of general movements: a feasibility study

Adde

Helbostad

Jensenius

et al. 2010

Develop Med Child Neuro

110

162

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AIM The aim of this study was to investigate the predictive value of a computer-based video analysis of the development of cerebral palsy (CP) in young infants.METHOD A prospective study of general movements used recordings from 30 high-risk infants (13 males, 17 females; mean gestational age 31wks, SD 6wks; range 23-42wks) between 10 and 15 weeks post term when fidgety movements should be present. Recordings were analysed using computer vision software. Movement variables, derived from differences between subsequent video frames, were used for quantitative analyses. CP status was reported at 5 years.RESULTS Thirteen infants developed CP (eight hemiparetic, four quadriparetic, one dyskinetic; seven ambulatory, three non-ambulatory, and three unknown function), of whom one had fidgety movements. Variability of the centroid of motion had a sensitivity of 85% and a specificity of 71% in identifying CP. By combining this with variables reflecting the amount of motion, specificity increased to 88%. Nine out of 10 children with CP, and for whom information about functional level was available, were correctly predicted with regard to ambulatory and non-ambulatory function.INTERPRETATION Prediction of CP can be provided by computer-based video analysis in young infants. The method may serve as an objective and feasible tool for early prediction of CP in highrisk infants.Cerebral palsy (CP) is a permanent disorder in the development of movement and posture in the developing fetal or infant brain 1 and is one of the major disabilities that result from extremely preterm birth. [2][3][4] The utility of predictive assessment tools in young infants is limited by the need for expensive equipment and highly experienced personnel, as well as low accuracy. Although the primary insult(s) cannot be repaired, early identification of CP enables intervention to be instituted while the plasticity of the nervous system is high. [5][6][7][8] Early identification may also lead to more focused follow-up and reassure the parents of those children who are unlikely to develop CP.In young infants, neurological damage is typically expressed by means of generalized and non-specific dysfunction. 9 The General Movement Assessment (GMA), based on systematic observation of infants' spontaneous movements from video recordings, has been shown to predict CP with high accuracy. 10,11 The absence of fidgety movements at 2 to 4 months corrected age may identify infants who will develop CP with more than 90% sensitivity. 10,[12][13][14] Although the GMA has been demonstrated to predict CP with high accuracy, it depends on highly experienced observers, and its use in clinical practice is limited. 12,15,16 A software program developed within the Max/MSP/Jitter environment for analysing music-related movements in musicians and dancers 17 has recently been customized for the purpose of studying fidgety movements. Using the customized software, movement variables have been demonstrated to identify infants with fidgety movements with high accuracy. 18 The aim of...

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“…The increased survival of very and extremely preterm infants has progressively led to the emergence of a significant group of infants at high risk for the development of motor, sensory, cognitive, and behavioral deficits, constituting a major challenge for our society (1)(2)(3). The prevention of neurological disabilities remains a preoccupying issue in public health, and no neuroprotective treatment to date has proven clinically useful in reducing lesions.…”

mentioning

confidence: 99%

Transplantation of umbilical cord–derived mesenchymal stem cells as a novel strategy to protect the central nervous system: technical aspects, preclinical studies, and clinical perspectives

2012

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Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study

Cited by 790 publications

References 35 publications

IL-1 Receptor Antagonist Protects against Placental and Neurodevelopmental Defects Induced by Maternal Inflammation

IL-1 Receptor Antagonist Protects against Placental and Neurodevelopmental Defects Induced by Maternal Inflammation

Early prediction of cerebral palsy by computer‐based video analysis of general movements: a feasibility study

Transplantation of umbilical cord–derived mesenchymal stem cells as a novel strategy to protect the central nervous system: technical aspects, preclinical studies, and clinical perspectives

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