Neurodevelopmental assessment of HIV-exposed uninfected and early-treated HIV-infected children: study protocol

Strehlau, Renate; Aswegen, Tamryn van; Potterton, Joanne

doi:10.1186/s13104-018-3331-8

Cited by 2 publications

(4 citation statements)

References 20 publications

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“…The effects of HIV infection on development can be overcome with treatment. Three studies investigated the outcomes of HIV care and demonstrated that infected infants and children who received HIV care achieved similar cognitive and motor scores to uninfected children at 6, 12 and 24 months ( 56‐58 ) .…”

Section: Resultsmentioning

confidence: 99%

Nutrition, growth, and other factors associated with early cognitive and motor development in Sub‐Saharan Africa: a scoping review

French

Outhwaite

Langley‐Evans

et al. 2020

J Human Nutrition Diet

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Background: Food insecurity, poverty and exposure to infectious disease are well-established drivers of malnutrition in children in Sub-Saharan Africa. Early development of cognitive and motor skillsthe foundations for learningmay also be compromised by the same or additional factors that restrict physical growth. However, little is known about factors associated with early child development in this region, which limits the scope to intervene effectively. To address this knowledge gap, we compared studies that have examined factors associated with early cognitive and/or motor development within this population. Methods: Predetermined criteria were used to examine four publication databases (PsycInfo, Embase, Web of Science and Medline) and identify studies considering the determinants of cognitive and motor development in children aged 0-8 years in Sub-Saharan Africa. Results: In total, 51 quantitative studies met the inclusion criteria, reporting on 30% of countries across the region. Within these papers, factors associated with early child development were grouped into five themes: Nutrition, Growth and Anthropometry, Maternal Health, Malaria and HIV, and Household. Food security and dietary diversity were associated with positive developmental outcomes, whereas exposure to HIV, malaria, poor maternal mental health, poor sanitation, maternal alcohol abuse and stunting were indicators of poor cognitive and motor development. Discussion: In this synthesis of research findings obtained across Sub-Saharan Africa, factors that restrict physical growth are also shown to hinder the development of early cognitive and motor skills, although additional factors also influence early developmental outcomes. The study also reviews the methodological limitations of conducting research using Western methods in sub-Saharan Africa.

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Section: Resultsmentioning

confidence: 99%

Nutrition, growth, and other factors associated with early cognitive and motor development in Sub‐Saharan Africa: a scoping review

French

Outhwaite

Langley‐Evans

et al. 2020

J Human Nutrition Diet

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“…After birth, infants enrolled into the IG of the neurodevelopmental study received a standardized set of age‐appropriate developmentally stimulating toys and books, as previously described (Strehlau, van Aswegen, & Potterton, 2018). Starting at birth, every 3 months, the caregiver was provided with an age‐specific information card along with pre‐specified toys and items to help stimulate infant development.…”

Section: Methodsmentioning

confidence: 99%

“…Study participation was voluntary, and non‐participation in the neurodevelopmental trial did not preclude participation in the main trial. The study was approved by the Human Research Ethics Committee of the University of the Witwatersrand (M170653), registered with the Pan African Clinical Trial Registry (PACTR201801002967587), and study protocol published (Strehlau, van Aswegen, & Potterton, 2018).…”

Section: Methodsmentioning

confidence: 99%

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Neurodevelopment in early treated HIV‐infected infants participating in a developmental stimulation programme compared with controls

Strehlau

Burke

Aswegen

et al. 2020

Child

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Background Neurodevelopmental stimulation programmes can improve developmental outcomes. Antiretroviral therapy (ART) started soon after birth potentially limits the invasion of HIV into the central nervous system. A combination of developmental stimulation and early ART initiation may reduce developmental delays in children with perinatally acquired HIV infection. Methods At a single site in Johannesburg, South Africa, we enrolled 36 HIV‐infected neonates on ART into an intervention group (IG) participating in a yearlong home‐based, neurodevelopmental stimulation programme. Bayley Scales of Infant and Toddler Development‐3rd Edition (BSID‐III) assessments were conducted at 12 months. Scores were compared with 24 early treated HIV‐infected infants in an observational group (OG). BSID‐III assessments were also conducted for older children in an OG at 24 or 36 months. Cognitive, language and motor scaled and composite scores were analysed. Results BSID‐III scaled and composite scores were all higher in the IG apart from the gross motor scaled score (9.25 vs. 10, p = 0.1954). Receptive communication scaled score was significantly higher in the IG (10.96 vs. 9, p = 0.0331). IG composite scores were all higher than OG scores. OG children assessed at 24 or 36 months had lower composite scores in all subscales than 12‐month OG scores. Conclusions Early treated HIV‐infected children participating in a neurodevelopmental stimulation programme achieved higher BSID‐III scores at 12 months compared with early treated HIV‐infected children who did not receive the programme.

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Neurodevelopmental assessment of HIV-exposed uninfected and early-treated HIV-infected children: study protocol

Cited by 2 publications

References 20 publications

Nutrition, growth, and other factors associated with early cognitive and motor development in Sub‐Saharan Africa: a scoping review

Nutrition, growth, and other factors associated with early cognitive and motor development in Sub‐Saharan Africa: a scoping review

Neurodevelopment in early treated HIV‐infected infants participating in a developmental stimulation programme compared with controls

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