Neurodevelopmental and Perinatal Correlates of Simple Brain Metrics in Very Preterm Infants

Tich, Sylvie Nguyen The; Anderson, Peter J.; Hunt, Rod W.; Lee, Katherine J.; Doyle, Lex W.; Inder, Terrie E.

doi:10.1001/archpediatrics.2011.9

Cited by 58 publications

(40 citation statements)

References 22 publications

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“…7,32,33 Here, a smaller TCD, indicative of neuronal loss or impaired neuronal differentiation with a reduction in dendritic and axonal development that may be independent of immaturity, 3 was associated with poor cognitive and psychomotor function. These results concur with those of the report of Tich et al 34 in preterm infants born at a gestational age Ͻ30 weeks or a weight of Ͻ1.25 kg. The cerebellar injury, mainly occurring in the external granular layer, possibly related to a disturbance of cerebellar growth caused by hemosiderin on the cerebellar surface or postnatal factors such as hypoxia-ischemia, infection, and steroids as well as direct cerebellar destructive injury.…”

Section: Discussionsupporting

confidence: 93%

“…Abnormalities of the cerebellum in mice after exposure to phenobarbital, such as a decrease in the number of Purkinje 37 and granular cells, 33 without an effect on the area of the cerebellum, have been reported. Sepsis, an independent risk factor for a poor neurologic outcome, 25,34,38 could have exerted a detrimental effect on the growth of the cerebellum by diffuse white matter injury, 24 bacterial products and cytokines, 39,40 arterial hypotension, and combined cerebral ischemia. 25 Bronchopulmonary dysplasia, a known risk factor for neurodevelopmental impairment, has also been reported to exert an effect on the granular cells of the cerebellum, as shown in a baboon model.…”

Section: Discussionmentioning

confidence: 99%

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Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes

Park

Yoon

Han³

et al. 2013

AJNR Am J Neuroradiol

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes

Park

Yoon

Han³

et al. 2013

AJNR Am J Neuroradiol

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“…21 The Mental Developmental Index (MDI) and the Psychomotor Developmental Index (PDI) were used for this analysis. Each scale has a normative mean (SD) of 100 (15). The St Louis cohort is more recent, and the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), was used to assess neurodevelopment at 2 years.…”

Section: Neurodevelopmental Outcomementioning

confidence: 99%

“…Therefore, an alternative, simpler biometric approach has been proposed to evaluate early brain growth in preterm infants. 14,15 These brain metrics, applied at term-equivalent postmenstrual age (TEA), correlate reasonably with three-dimensional volumetric measures 14 and are readily used in a clinical setting. We applied these brain metrics along with a new grading system to assess brain injury on conventional MRI to characterize the patterns of brain injury and impaired brain growth in VPT infants at TEA.…”

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confidence: 98%

Brain Injury and Altered Brain Growth in Preterm Infants: Predictors and Prognosis

et al. 2014

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Brain Injury and Altered Brain Growth in Preterm Infants: Predictors and PrognosisWHAT'S KNOWN ON THIS SUBJECT: Term MRI can assist in identifying the nature and extent of brain injury in preterm infants. However, brain injury detected by MRI does not fully account for neurodevelopmental impairments, particularly cognitive and behavioral impairments, common in preterm survivors. WHAT THIS STUDY ADDS:In addition to brain injury, an assessment of brain growth by using one-dimensional measurements on MRI is helpful for predicting neurodevelopment. Two different patterns of impaired brain growth are observed that relate independently to early cognitive development in preterm infants. abstract BACKGROUND: To define the nature and frequency of brain injury and brain growth impairment in very preterm (VPT) infants by using MRI at term-equivalent age and to relate these findings to perinatal risk factors and 2-year neurodevelopmental outcomes.METHODS: MRI scans at term-equivalent age from 3 VPT cohorts (n = 325) were reviewed. The severity of brain injury, including periventricular leukomalacia and intraventricular and cerebellar hemorrhage, was graded. Brain growth was assessed by using measures of biparietal width (BPW) and interhemispheric distance. Neurodevelopmental outcome at age 2 years was assessed across all cohorts (n = 297) by using the Bayley Scales of Infant Development, Second Edition (BSID-II) or Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III), and evaluation for cerebral palsy. RESULTS:Of 325 infants, 107 (33%) had some grade of brain injury and 33 (10%) had severe injury. Severe brain injury was more common in infants with lower Apgar scores, necrotizing enterocolitis, inotropic support, and patent ductus arteriosus. Severe brain injury was associated with delayed cognitive and motor development and cerebral palsy. Decreased BPW was related to lower gestational age, inotropic support, patent ductus arteriosus, necrotizing enterocolitis, prolonged parenteral nutrition, and oxygen at 36 weeks and was associated with delayed cognitive development. In contrast, increased interhemispheric distance was related to male gender, dexamethasone use, and severe brain injury. It was also associated with reduced cognitive development, independent of BPW.CONCLUSIONS: At term-equivalent age, VPT infants showed both brain injury and impaired brain growth on MRI. Severe brain injury and impaired brain growth patterns were independently associated with perinatal risk factors and delayed cognitive development. Pediatrics 2014;134:e444-e453 Dr Kidokoro contributed to the study concept and design, assessed the MRI findings, performed the statistical analyses, and wrote the first draft of the manuscript; Drs Anderson and Doyle contributed to the collection of the Australian data presented in this article and revised the manuscript for important intellectual content; Dr Woodward contributed to the collection of the New Zealand data presented in this article and revised the manuscript for important i...

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“…31 When related to neurodevelopment at 24 months of age, bifrontal diameter and biparietal diameter at TEA were significantly associated with cognitive and motor development. 32 Kidokoro et al 33 recently examined brain growth, using biometric techniques, and neurodevelopment at 24 months of age in a combined cohort from Christchurch, Melbourne, and St Louis. VP children who had small biparietal diameter or increased interhemispheric distance at TEA had poorer cognitive development than children classified as having appropriate growth.…”

Section: Cortical Gray Matter Abnormalitymentioning

confidence: 99%

The predictive validity of neonatal MRI for neurodevelopmental outcome in very preterm children

Anderson

Cheong

Thompson

2015

Seminars in Perinatology

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106

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Neurodevelopmental and Perinatal Correlates of Simple Brain Metrics in Very Preterm Infants

Cited by 58 publications

References 22 publications

Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes

Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes

Brain Injury and Altered Brain Growth in Preterm Infants: Predictors and Prognosis

The predictive validity of neonatal MRI for neurodevelopmental outcome in very preterm children

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