Neurodevelopment and Endocrine Disruption

Colborn, Theo

doi:10.1289/ehp.6601

Cited by 233 publications

(140 citation statements)

References 50 publications

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“…Chemical exposure was considered one candidate etiology (12)(13)(14), however, the present study revealed no statistically significant association between PCBs concentration in preserved umbilical cords and autism. Firm conclusions cannot be drawn from the present results as to whether in utero PCBs exposure is not one of the etiologies of autism because of the small sample size as well as the external contamination of preserved umbilical cord samples used as an indicator of in utero exposure to PCBs.…”

Section: Resultscontrasting

confidence: 78%

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Retrospectivein utero exposure assessment of PCBs using preserved umbilical cords and its application to case-control comparison

Otake

Yoshinaga

Seki³

et al. 2006

Environ Health Prev Med

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Objectives: The aim of this study is to assess preserved umbilical cords as chemical exposure media to investigate in utero chemical exposure. Furthermore, we aim to apply preserved umbilical cords to retrospective studies of the relationship between in utero chemical exposure and neurodevelopment disorders.Methods: Two sets of preserved umbilical cord samples were analyzed for exposure to polychlorinated biphenyls (PCBs): one composed of samples from 20 healthy Japanese subjects and the other set included samples from 17 autistic patients and 7 healthy siblings of theirs.Results: The possibility of external PCBs contamination during storage of preserved umbilical cord samples was found, and due to this problem, the study design should be limited to the comparison between PCBs concentration in preserved cord samples from autistic patients and that in those from their sibling. Total PCBs concentrations in preserved cords from autistic patients and their control siblings were compared and we found no statistically significant difference between them (Wilcoxon signed rank test, p>0.05).Conclusions: The association between autism and in utero PCBs exposure was not clarified in this study; however, retrospective studies such as a case-control study of siblings using preserved umbilical cords can be a method of choice for examining the possible relationship between in utero chemical exposure and childhood disorders.

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Section: Resultscontrasting

confidence: 78%

“…We applied our proposed in utero exposure assessment method to autistic patients to determine whether there is any relationship between autism and in utero PCBs exposure. Chemical exposure is suspected as one of the etiologies of autism (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Retrospectivein utero exposure assessment of PCBs using preserved umbilical cords and its application to case-control comparison

Otake

Yoshinaga

Seki³

et al. 2006

Environ Health Prev Med

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“…Many studies on endocrine disruption and NRs have discussed reproductive effects and effects on the immune and nervous systems, and several excellent reviews are available on these topics (Singleton & Khan 2003, Colborn 2004, Panzica et al 2005, Vidaeff & Sever 2005, Tabb & Blumberg 2006. We focus here on the possible involvement of EDCs in the development of obesity and metabolic syndrome (MetS).…”

Section: Is Exposure To Edcs Involved In Development Of Metabolic Dismentioning

confidence: 99%

Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders

Swedenborg¹,

Rüegg²,

Mäkelä³

et al. 2009

Journal of Molecular Endocrinology

254

160

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Endocrine disruption refers to the ability of chemicals to interfere with hormonal systems, and has raised considerable concern in recent years. Endocrine disruptive chemicals (EDCs) pose a documented risk to wildlife and have the potential to negatively influence human health. This review focuses on the molecular mechanisms of endocrine disruption and the possible involvement of EDCs in metabolic disorders. The first part describes the role of aryl hydrocarbon receptor (AhR) and nuclear receptors (NRs) in mediating effects of EDCs, in particular, how cross-talk between AhR and NR pathways can lead to endocrine disruption. The second part deals with how these receptors are involved in metabolic functions and how their targeting by EDCs can lead to disturbances in glucose and fat metabolism. The article illustrates that, although there is accumulating data on molecular mechanisms of EDC action as well as on EDC involvement in metabolic disorders, there is still a great demand for data that can unite the mechanistic and the toxicological /epidemiological observations.

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“…It prepared scientists to entertain the possibility that endocrine-disrupting environmental chemicals could also interfere with developmental processes. Many publications have explored these implications (e.g., Colborn, 2004;Schantz and Widholm, 2001;Weiss, 2002a;Melcagni and Panzica, 2006). The effects of these chemicals on aging, in contrast, are a tabula rasa.…”

Section: Endocrine Disruptorsmentioning

confidence: 99%

Can endocrine disruptors influence neuroplasticity in the aging brain?

Weiss

2007

NeuroToxicology

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Only within the last two decades has the adult mammalian brain been recognized for its ability to generate new nerve cells and other neural structures and in essence to rewire itself. Although hippocampal structures have received the greatest scrutiny, other sites, including the cerebral cortex, also display this potential. Such processes remain active in the aging brain, although to a lesser degree. Two of the factors known to induce neurogenesis are environmental enrichment and physical activity. Gonadal hormones, however, also play crucial roles. Androgens and estrogens are both required for the preservation of cognitive function during aging and apparently help counteract the risk of Alzheimer's disease. One overlooked threat to hormonal adequacy that requires close examination is the abundance of environmental endocrine-disrupting chemicals that interfere with gonadal function. They come in the form of estrogenic mimics, androgen mimics, anti-estrogens, antiandrogens, and in a variety of other guises. Because our brains are in continuous transition throughout the lifespan, responding both to environmental circumstances and to changing levels of gonadal steroids, endocrine-disrupting chemicals possess the potential to impair neurogenesis, and represent a hazard for the preservation of cognitive function during the later stages of the life cycle.

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Neurodevelopment and Endocrine Disruption

Cited by 233 publications

References 50 publications

Retrospectivein utero exposure assessment of PCBs using preserved umbilical cords and its application to case-control comparison

Retrospectivein utero exposure assessment of PCBs using preserved umbilical cords and its application to case-control comparison

Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders

Can endocrine disruptors influence neuroplasticity in the aging brain?

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