Neurodegenerative model of schizophrenia: Growing evidence to support a revisit

The Potential of Myelin-Sensitive Imaging: Redefining Spatiotemporal Patterns of Myeloarchitecture

“…Yet, the nature of dysmyelination in schizophrenia, especially its progression, remains a contentious issue. Hypotheses variably focus on abnormal neurodevelopment (148) or accelerated neurodegeneration (149). The above-discussed advances in myelin imaging, analytics and lifespan research pave the way to accurately track and characterise aberrant age-related changes in myelin in individuals with schizophrenia, thereby disentangling competing theories, improving understanding of the aetiology of the disease and benefitting models of clinical J o u r n a l P r e -p r o o f course.…”

Cognitive enhancement interventions are effective for schizophrenia: why not provide them early?

“…Yet, the SDG monitoring process has collected little data on access to quality education for children with disabilities overall, and even less on the experience of children with mental health conditions. Meanwhile, data available from other sources suggest that we have far to go: our study of policies in 193 countries found that over one-third fail to even guarantee integrated education along with individualized supports for children with disabilities, and much less specifically address the needs of children with mental health conditions 8 .…”

Nanosystems for Brain Targeting of Antipsychotic Drugs: An Update on the Most Promising Nanocarriers for Increased Bioavailability and Therapeutic Efficacy

“…Among them, schizophrenia and bipolar disorder are the most prevalent, affecting around 24 and 40 million people worldwide over the last decade, respectively [ 1 , 2 , 3 , 4 , 5 ]. Schizophrenia is a chronic disorder, most commonly beginning in late adolescence and early adulthood, characterized by the presence of positive symptoms, such as hallucinations, delusions and significant and intense changes in thought and behavior (such as self or hetero-aggressiveness, agitation and bizarre attitudes), negative symptoms, such as dementia, impairment of interpersonal relationships, social isolation, apathy, alogia, anhedonia and lack of motivation and initiative to perform ordinary everyday activities, and cognitive symptoms, such as marked deficits in verbal and working memory, vigilance and attention [ 6 , 7 , 8 , 9 , 10 ]. In turn, bipolar disorder is also a chronic mental illness, typically characterized by either recurrent depressive episodes, including feelings of deep sadness and energy loss, or episodes of mania/hypomania, including periods during which people feel overly exhilarated, happy, irritable and/or energetic, with a reduced need to sleep [ 11 , 12 , 13 ].…”